Esmolol Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
Esmolol is a cardioselective beta1 receptor blocking agent.
Hazard
A reproductive hazard.
Clinical Use
Esmolol (Brevibloc) is a short-acting intravenously administered
β1-selective adrenoceptor blocking agent. It
does not possess membrane-stabilizing activity or sympathomimetic
activity.
Esmolol is used in the treatment of supraventricular
tachyarrhythmias for rapid control of ventricular rate
and reduction of myocardial oxygen consumption.
Discontinuation of administration is followed by a rapid
reversal of its pharmacological effects because of esmolol’s
rapid hydrolysis by plasma esterases.
Nebenwirkungen
The most frequently reported adverse effects are hypotension,
nausea, dizziness, headache, and dyspnea.As
with many β-blocking drugs, esmolol is contraindicated
in patients with overt heart failure and those in cardiogenic
shock.
Stoffwechsel
The -blocker esmolol (Brevibloc) is unusual in that
it is very rapidly metabolized; its plasma half-life is only
9 minutes. It is subject to hydrolysis by cytosolic esterases
in red blood cells to yield methanol and an acid
metabolite, the latter having an elimination half-life of
about 4 hours. Only 2% of the administered esmolol is
excreted unchanged. Because of its rapid onset and short duration of action, esmolol is used by the intravenous
route for the control of ventricular arrhythmias
in emergencies.
Esmolol Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
