2-Cyano-3-hydroxy-N-(4'-trifluoromethylphenyl)-crotone amide
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- CAS-Nr.
- 108605-62-5
- Englisch Name:
- 2-Cyano-3-hydroxy-N-(4'-trifluoromethylphenyl)-crotone amide
- Synonyma:
- Teriflunomide;Su 20;CS-862;Aubagio;Aids013145;Aids-013145;rac-A77 1626;(E/Z)-Teriflunomide;TeriflunoMide, A77 1726;Teriflunomide((E/Z) Mixture)
- CBNumber:
- CB6464433
- Summenformel:
- C12H9F3N2O2
- Molgewicht:
- 270.21
- MOL-Datei:
- 108605-62-5.mol
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2-Cyano-3-hydroxy-N-(4'-trifluoromethylphenyl)-crotone amide Eigenschaften
- Schmelzpunkt:
- 229-232°C
- Siedepunkt:
- 410.8±45.0 °C(Predicted)
- Dichte
- 1.424±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- L?slichkeit
- Soluble in DMSO (up to 30 mg/ml), or in Ethanol (up to 5 mg/ml with warming).
- pka
- 5.20±0.50(Predicted)
- Aggregatzustand
- Solid
- Farbe
- White
- Stabilit?t:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
- Major Application
- pharmaceutical
- InChI
- 1S/C12H9F3N2O2/c1-7(18)10(6-16)11(19)17-9-4-2-8(3-5-9)12(13,14)15/h2-5,18H,1H3,(H,17,19)/b10-7-
- InChIKey
- UTNUDOFZCWSZMS-YFHOEESVSA-N
- SMILES
- O=C(/C(C#N)=C(O)/C)NC1=CC=C(C(F)(F)F)C=C1
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Kennzeichnung gef?hrlicher |
Xn |
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| R-S?tze: |
22 |
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| WGK Germany |
WGK 3 |
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| HS Code |
2926900005 |
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| Speicherklasse |
6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects |
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| Hazard Classifications |
Acute Tox. 3 Oral |
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| Toxizit?t |
mouse,LD50,intraperitoneal,100mg/kg (100mg/kg),United States Patent Document. Vol. #5494911, |
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| Bildanzeige (GHS) |
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| Alarmwort |
Achtung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H301 |
Giftig bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 3 |
Achtung |
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P264, P270, P301+P310, P321, P330,P405, P501 |
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| Sicherheit |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P270 |
Bei Gebrauch nicht essen, trinken oder rauchen. |
| P301+P310 |
BEI VERSCHLUCKEN: Sofort GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen. |
| P405 |
Unter Verschluss aufbewahren. |
| P501 |
Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen. |
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2-Cyano-3-hydroxy-N-(4'-trifluoromethylphenyl)-crotone amide Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Teriflunomide (Aubagio®), also known as A77 1726, is an immunosupressant marketed by Sanofi for
the teatment of multiple sclerosis (MS). Teriflunomide is the active metabolite of leflunomide, used
for treatment of patients diagnosed with rheumatoid arthritis, and therefore simultaneously can be used
as a treatment for rheumatoid arthritis.Teriflunomide acts as an inhibitor of the mitochondrial
enzyme dihydrorotate dehydrogenase, inhibiting pyrimidine formation, and resulting in reduced
B and T cell proliferation.
Chemische Eigenschaften
White Solid
Verwenden
The active metabolite of Leflunomide, 2-Cyano-3-hydroxy-N-(4'-trifluoromethylphenyl)-crotone amide can be used as a potent disease-modifying antirheumatic drug used in the treatment of rheumatoid arthritis.
2-Cyano-3-hydroxy-N-(4'-trifluoromethylphenyl)-crotone amide Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
2-Cyano-3-hydroxy-N-(4'-trifluoromethylphenyl)-crotone amide Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 197)Lieferanten
108605-62-5()Verwandte Suche:
- N-(4-Trifluoromethylphenyl)-2-cyano-3-hydroxycrotonamide, 2-Cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]-2-beuteamide, LEF-M
- (2Z)-2-[hydroxy-[[4-(trifluoromethyl)phenyl]amino]methylidene]-3-oxo-butanenitrile
- 2-Cyano-3OH-N-(4-trifluoromethylphenyl) crotonamide-d4
- IMp. A (EP) as Hydrochloride: 4-(TrifluoroMethyl)aniline Hydrochloride
- TeriflunoMide, A77 1726
- 2-Cyano-3-hydroxy-N-(4-trifluoromethylphenyl)crotonamide
- 2-Cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]but-2-enamide
- 2-Cyano-3-hydroxy-N-(4'-trifluoromethylphenyl)-crotone amide
- (E)-2-Cyano-3-hydroxy-N-(4-trifluoromethylphenyl)-2-butenamide
- 2-Butenamide, 2-cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]-
- Aids013145
- Aids-013145
- Su 20
- (Z)-2-cyano-3-hydroxy-N-(4-(trifluoroMethyl)phenyl)but-2-enaMide
- Leflunomide Related Compound B (10 mg) (2-Cyano-3-hydroxy-N-(4'-trifluoromethylphenyl)-crotone amide)
- 2-Cyano-3-hydroxy-N-(4-(trifluoromethyl)phenyl)but-2-enamide,teriflunomide
- Leflunomide Related Compound B (20 mg) (2-Cyano-3-hydroxy-N-(4'-trifluoromethylphenyl)-crotone amide)
- 2-cyano-3-hydroxy-n-(4-(trifluoromethyl)phenyl)-2-butenamid
- n-(4-trifluoromethylphenyl)-2-cyano-2-hydroxycrotonamide
- N-(4-TRIFLUOROMETHYLPHENYL)-2-CYANO-3-HYDROXYCROTOAMIDE
- N-(4-TRIFLUOROMETHYLPHENYL)-2-CYANO-3-HYDROXYCROTONAMIDE
- 2-CYANO-3-OH-N-(4-TRIFLUOROMETHYLPHENYL) CROTONAMIDE
- 2-CYANO-3-HYDROXY-N-[4-(TRIFLUOROMETHYL)PHENYL]-2-BUTENAMIDE
- Teriflunomide(Random Configuration)
- (2Z)-2-[hydroxy-[4-(trifluoromethyl)anilino]methylidene]-3-oxobutanenitrile
- Leflunomide ImpuritⅡ: 2-Cyano-3-hydroxy-N-(4'-trifluoromethylphenyl)-crotone amide
- CS-862
- 2-Cyano-3-hydroxy-N-(4-trifluoromethylphenyl)cro
- rac-A77 1626
- Leflunomide impurityⅡ[2-cyano-3-hydroxy-N-(4’-trifluoromethylphenyl)-crotone amide]
- Aubagio
- 2-Cyano-3-hydroxy-N-(4'-trifluoromethylphenyl)-crotone amide USP/EP/BP
- Teriflunomide((E/Z) Mixture)
- Leflunomide USP Related Compound B
- Leflunomide Related Compound B (2-Cyano-3-hydroxy-N-(4''-trifluoromethylphenyl)-crotone amide) (1357056)
- Leflunomide impurityⅡ
[2-cyano-3-hydroxy-N-(4’
-trifluoromethylphenyl)-croton e amide
- (E/Z)-Teriflunomide
- 2-cyano-3-hydroxy-crotonic acid 4-trifluoro-methyl-anilide
- A771726 (Teriflunomide), Active metabolite of leflunomide. Dihydroorotate dehydrogenase inhibitor.
- (E/Z)-Teriflunomide, 10 mM in DMSO
- 2-Cyano-3-hydroxy-N-(4-trifluoromethylphenyl)crotonamide/Leflunomide impurityⅡ
- Teriflunomide
- 108605-62-5
- C12H5F3N2O2D4
- Various Metabolites and Impurities
- Metabolites & Impurities
- Tyrosine Kinase Inhibitors
