(3 alpha, 4 beta, 8 alpha)-12,13-Epoxytrichothec-9-en-3,4,8,15-tetrol-4,15-diacetat-8-(3-methylbutyrat)

21259-20-1

CAS-Nr.: 21259-20-1

Bezeichnung:: (3 alpha, 4 beta, 8 alpha)-12,13-Epoxytrichothec-9-en-3,4,8,15-tetrol-4,15-diacetat-8-(3-methylbutyrat)

Englisch Name:: T-2 TOXIN

Synonyma:: toxint2;Toxin T 2;hothecene;nsc138780;T-2 TOXIN;T-2 toxins;alerate[qr];FUSARITOXIN;t-2mycotoxin;Insariotoxin

CBNumber:: CB6469458

Summenformel:: C24H34O9

Molgewicht:: 466.52

MOL-Datei:: 21259-20-1.mol

Request For Quotation

Eigenschaften Sicherheit Verwendungswort Produktionsfirma 134

(3 alpha, 4 beta, 8 alpha)-12,13-Epoxytrichothec-9-en-3,4,8,15-tetrol-4,15-diacetat-8-(3-methylbutyrat) Eigenschaften

Schmelzpunkt:: 151.5℃

alpha: D26 +15° (c = 2.58 in ethanol)

Siedepunkt:: 489.35°C (rough estimate)

Dichte: 1.1942 (rough estimate)

Brechungsindex: 1.6230 (estimate)

Flammpunkt:: 2 °C

storage temp.: −20°C

L?slichkeit: DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml; Ethanol: 20 mg/ml

Aggregatzustand: powder

pka: 13.24±0.70(Predicted)

Farbe: white

Merck: 13,9872

Henry's Law Constant: 1.8×10¹² mol/(m³Pa) at 25℃, HSDB (2015)

Major Application: cleaning products
cosmetics
food and beverages
personal care

InChIKey: BXFOFFBJRFZBQZ-QYWOHJEZSA-N

SMILES: C[C@@]12[C@@H]([C@H]([C@@]([H])(O[C@]3([H])C=C([C@H](C[C@]13COC(=O)C)OC(=O)CC(C)C)C)[C@@]12OC1)O)OC(=O)C

IARC: 3 (Vol. 31, Sup 7) 1987

Sicherheit

Risiko- und Sicherheitserkl?rung
Gefahreninformationscode (GHS)

Kennzeichnung gef?hrlicher	T+,T,Xn,F
R-S?tze:	26/27/28-38-36-20/21/22-11
S-S?tze:	28-36/37-45-36-26-16-36/37/39-22
RIDADR	UN 3462 6.1/PG 1
WGK Germany	3
RTECS-Nr.	YD0100000
F	10-21
HazardClass	6.1(a)
PackingGroup	I
HS Code	29329990
Speicherklasse	3 - Flammable liquids
Hazard Classifications	Acute Tox. 4 Dermal Acute Tox. 4 Inhalation Acute Tox. 4 Oral Eye Irrit. 2 Flam. Liq. 2
Giftige Stoffe Daten	21259-20-1(Hazardous Substances Data)
Toxizit?t	LD50 orally in female rats: 4.0 mg/kg (Marasas); LD50 (mg/kg) in mice: 5.2 i.p., 4.2 i.v.; in rats: 7.0 intragastric, 0.9-1.3 i.p., 0.9 i.v., 2.0 s.c.; in guinea pigs: 3.0-4.0 orally, 5.3 intragastric, 1.0 i.m., 1.0-2.0 i.v., 1.0-2.0 s.c.; in pigs: 5.0 orally, 3.0 i.v. (Yagen, Bailer)

Bildanzeige (GHS)

Alarmwort

Achtung

Gefahrenhinweise

Code	Gefahrenhinweise	Gefahrenklasse	Abteilung	Alarmwort	Symbol	P-Code
H315	Verursacht Hautreizungen.	Hautreizung	Kategorie 2	Warnung		P264, P280, P302+P352, P321,P332+P313, P362

Sicherheit

P262	Nicht in die Augen, auf die Haut oder auf die Kleidung gelangen lassen.
P280	Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.

(3 alpha, 4 beta, 8 alpha)-12,13-Epoxytrichothec-9-en-3,4,8,15-tetrol-4,15-diacetat-8-(3-methylbutyrat) Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R26/27/28:Sehr giftig beim Einatmen, Verschlucken und Berührung mit der Haut.
R38:Reizt die Haut.
R36:Reizt die Augen.
R20/21/22:Gesundheitssch?dlich beim Einatmen,Verschlucken und Berührung mit der Haut.
R11:Leichtentzündlich.

S-S?tze Betriebsanweisung:

S28:Bei Berührung mit der Haut sofort abwaschen mit viel . . . (vom Hersteller anzugeben).
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn m?glich, dieses Etikett vorzeigen).
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S16:Von Zündquellen fernhalten - Nicht rauchen.

Beschreibung

T-2 toxin is a trichothecene mycotoxin that has been found in Fusarium. It binds to and inhibits peptidyltransferase in the 60S ribosomal subunit, inducing a ribotoxic stress response that triggers JNK and p38 MAPK signaling. T-2 toxin (3 nM) decreases toll-like receptor expression and LPS-induced production of IL-1β, TNF-α, and nitric oxide (NO) in, and is cytotoxic to (IC₅₀ = 19.47), primary pig alveolar macrophages (PAMs). In vivo, T-2 toxin induces production of reactive oxygen species (ROS), lipid peroxidation, and glutathione (GSH) depletion in mouse brain and is lethal to mice (LD₅₀s = 1.54-5.94 mg/kg). It also induces hepatocyte apoptosis and dyslipidemias in mice. T-2 toxin has been found in Fusarium-infected wheat, barley, and rice crops both in fields and in storage.

Chemische Eigenschaften

White powder

Verwenden

T-2 Toxin is a tricothecene mycotoxin produced by fungi of the genus Fusarium. T-2 Toxin induces DNA damage and cell death on prolonged administration.

Allgemeine Beschreibung

T-2 Toxin is found to be a potent trichothecene mycotoxin produced by the genus fusarium fungi in feedstuffs and cereal grains.

Sicherheitsprofil

Poison by ingestion, intramuscular, subcutaneous, intraperitoneal, intracerebral, and intravenous routes. Moderately toxic by inhalation. Experimental teratogenic and reproductive effects. A skin irritant. Questionable carcinogen with experimental neoplastigenic data. Mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes.

(3 alpha, 4 beta, 8 alpha)-12,13-Epoxytrichothec-9-en-3,4,8,15-tetrol-4,15-diacetat-8-(3-methylbutyrat) Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

NEOSOLANIOL

(3 alpha, 4 beta, 8 alpha)-12,13-Epoxytrichothec-9-en-3,4,8,15-tetrol-4,15-diacetat-8-(3-methylbutyrat) Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 134)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Hebei Yanxi Chemical Co., Ltd.	+8618531123677	faithe@yan-xi.com	China	5853	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21587	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29792	58
Hubei Ipure Biology Co., Ltd	+8613367258412	ada@ipurechemical.com	China	10236	58
HONG KONG IPURE BIOLOGY CO.,LIMITED	86 18062405514 18062405514	ada@ipurechemical.com	CHINA	3461	58
Wuhan Topule Biopharmaceutical Co., Ltd	+8618327326525	masar@topule.com	China	8467	58
Shanghai Acmec Biochemical Technology Co., Ltd.	+86-18621343501; +undefined18621343501	product@acmec-e.com	China	33324	58
Aladdin Scientific		tp@aladdinsci.com	United States	57505	58
Wuhan Jingkang en Biomedical Technology Co., Ltd	+8613720134139	orders@jknbiochem.com	China	5221	58

21259-20-1((3 alpha, 4 beta, 8 alpha)-12,13-Epoxytrichothec-9-en-3,4,8,15-tetrol-4,15-diacetat-8-(3-methylbutyrat))Verwandte Suche:

3,4,5,6,9,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacy-clotetradecin-1,7(8H)-dion,(S-(E))- (3 alpha, 4 beta, 8 alpha)-12,13-Epoxytrichothec-9-en-3,4,8,15-tetrol-4,15-diacetat-8-(3-methylbutyrat) 12,13-Epoxytrichothec-9-en-3α,4β,15-triol-4,15-diacetat Tetrahydro-4-methyl-2-(2-methylprop-1-enyl)pyran 3-Methyl-2-(3-methylbut-2-enyl)butan-1,3-diyldiacetat

4β,15-Diacetoxy-8α-(3-Methylbutyryloxy)- 12,13-epoxytrichothec-9-en-3α-ol
8α-(3-Methylbutyryloxy)-4β,15- diacetoxyscirp-9-en-3α-ol
T-2 LienoMycin
T-2 Toxin, froM FusariuM tricinctuM
12,13-epoxytrichothec-9-ene-3-alpha,4-beta,8-alpha,15-tetrol4,15-diacetate8
12,13-trichothecene
3alpha-Hydroxy-4beta,15-diacetoxy-8alpha(3-methylbutyryloxy)-12,13-epoxy-trichothec-9-ene
3alpha-hydroxy-4beta-15-diacetoxy-8alpha-(3-methylbutyryloxy)-12,13-epoxy-delt
3-hydroxy-4,15-diacetoxy-8-(3-methylbutyryloxy)-12,13-epoxy-delta(sup9)-tric
3-hydroxy-4,15-diacetoxy-8-(3-methylbutyryloxy)-12,13-epoxy-delta-(sup9)-trich
3-hydroxy-4,15-diacetoxy-8-[3-methylbutyryloxy]-12,13-epoxytrichothec-9-ene
4,15-diacetoxy-8-(3-methylbutyryloxy)-12,13-epoxy-delta-9-trichothecen-3-ol
4,15-diacetoxy-8-(3-methylbutyryloxy)-12,13-epoxy-delta-9-trichothecen-3-ol[qr
4,15-diacetoxy-8-(3-methylbutyryloxy)scirp-9-en-3-ol
4-beta,15-diacetoxy-8-alpha-(3-methylbutyryloxy)-3-alpha-hydroxy-12,13-epoxy
4beta,8alpha,15-tetrol,12,13-epoxy-,4,15-diacetate8-trichothec-9-ene-3alph
8-(3-methylbutyryloxy)-diacetoxy-scirpeno
8-(3-Methylbutyryloxy)diacetoxyscirpenol
8-(3-methylbutyryloxy)-diacetoxyscirpenol
8-(3-methylbutyryloxy)-diacetoxyscirpenol[qr]
8alpha-(3-methylbutyryloxy)-4beta,15-diacetoxyscirp-9-en-3alpha-ol[qr]
8-isovalerate
a9-tricothecene[qr]
alerate[qr]
fusariotoxinet2
fusariotoxinet2[qr]
t(sub2)-trichothecene[qr]
t-2mycotoxin
t-2mycotoxin[qr]
t2-trichothecene[qr]
Toxin T 2
toxint2
trichothec-9-ene
Trichothec-9-ene-3,4,8,15-tetrol, 12,13-epoxy-, 4,15-diacetate 8-(3-methylbutanoate), (3alpha,4beta,8alpha)-
8alpha-(3-Methylbutyryloxy)-4beta,15-diacetoxyscirp-9-en-3alpha-ol
T2 Toxin / Fusariotoxin T 2 / Insariotoxin / Mycotoxin T 2
hothecene
Insariotoxin
insariotoxin[qr]
isaritoxin[qr]
-isovalerate
nsc138780
nsc138780[qr]
othecene[qr]
Scirpenol, 8-(3-methylbutyryloxy)-diacetoxy-
trichothec-9-ene-3,4,8,15-tetrol,12,13-epoxy-,4,15-diacetate8-(3-methylbutan
Trichothec-9-ene-3alpha,4beta,8alpha,15-tetrol, 12,13-epoxy-, 4,15-diacetate 8-isovalerate
trichothec-9-ene-3-alpha,4-beta,8-alpha,15-tetrol,12,13-epoxy-,4,15-diacetate
MYCOTOXIN TRICHOTHECENE 2
MYCOTOXIN T 2
T-2 TOXIN
(3-ALPHA, 4-BETA, 8-ALPHA)-TRICHOTHEC-9-ENE-3,4,8,15-TETROL,12,13-EPOXY-, 4,15-DIACETATE 8-(3-METHYLBUTANOATE)
4BETA,15-DIACETOXY-3ALPHA-HYDROXY-8ALPHA-[3-METHYLBUTYRYLOXY]-12,13-EPOXYTRICHOTHEC-9-ENE
FUSARIOTOXIN
FUSARIOTOXIN T 2
FUSARITOXIN
EPOXYTRICHOTHECENE
T-2 toxin from fusarium sp

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