7-CYCLOPENTYL-5-(4-PHENOXY)PHENYL-7H-PYR
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- CAS-Nr.
- 213743-31-8
- Englisch Name:
- 7-CYCLOPENTYL-5-(4-PHENOXY)PHENYL-7H-PYR
- Synonyma:
- RK-24466;KIN001-051;KIN 001-51;d]pyrimidin-4-ylamine;RK-24466, 10 mM in DMSO;RK-24466 ;RK 24466 ;RK24466;7-CYCLOPENTYL-5-(4-PHENOXY)PHENYL-7H-PYR;Lck Inhibitor - CAS 213743-31-8 - Calbiochem;RK-24466,Src,Inhibitor,inhibit,RK 24466,RK24466;7-Cyclopentyl-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
- CBNumber:
- CB6497372
- Summenformel:
- C23H22N4O
- Molgewicht:
- 370.45
- MOL-Datei:
- 213743-31-8.mol
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7-CYCLOPENTYL-5-(4-PHENOXY)PHENYL-7H-PYR Eigenschaften
- Siedepunkt:
- 605.1±55.0 °C(Predicted)
- Dichte
- 1.30±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- L?slichkeit
- DMSO: 17 mg/mL at ≤60 °C, soluble
- pka
- 5.75±0.30(Predicted)
- Aggregatzustand
- White solid
- Farbe
- white
- InChI
- 1S/C23H22N4O/c24-22-21-20(14-27(17-6-4-5-7-17)23(21)26-15-25-22)16-10-12-19(13-11-16)28-18-8-2-1-3-9-18/h1-3,8-15,17H,4-7H2,(H2,24,25,26)
- InChIKey
- FMETVQKSDIOGPX-UHFFFAOYSA-N
- SMILES
- Nc1ncnc2n(cc(-c3ccc(Oc4ccccc4)cc3)c12)C5CCCC5
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| WGK Germany |
3 |
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| Speicherklasse |
11 - Combustible Solids |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
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P264, P270, P301+P312, P330, P501 |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
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P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
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P264, P280, P305+P351+P338,P337+P313P |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizit?t (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
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| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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7-CYCLOPENTYL-5-(4-PHENOXY)PHENYL-7H-PYR Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
Lck Inhibitor is a cell-permeable ATP-competitive inhibitor of Lck.
Allgemeine Beschreibung
A cell-permeable pyrrolopyrimidine compound that acts as a potent, reversible, selective, and ATP-competitive inhibitor of Lck (IC
50 at 5 μM ATP = <1 nM, 2 nM, 70 nM, 1.57 μM and 1.98 μM for lck
64-509 Y
394, Lckcd pY
394, Src, Kdr and Tie-2, respectively; IC
50 at 1 mM ATP = 16 μM, 66 nM, 126 nM, 420 nM and 5.18 μM for Lck
64-509 Y
394, Blk, Fyn, Lyn and Csk, respectively). Only minimally affects the activities of other kinases (IC
50 = 3.2 μM, >33 μM, >50 μM and >50 μM for EGFR, PKC, CDC2/B and ZAP-70, respectively). Also shown to potently block T-cell receptor-stimulated IL-2 production
in vitro (IC
50<1-40 nM in Jurkat T cells) and
in vivo (ED
50 = 4 mg/kg in mice, ip.)
Biochem/physiol Actions
Primary TargetLck Y3
7-CYCLOPENTYL-5-(4-PHENOXY)PHENYL-7H-PYR Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
7-CYCLOPENTYL-5-(4-PHENOXY)PHENYL-7H-PYR Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 66)Lieferanten
- 7-CYCLOPENTYL-5-(4-PHENOXY)PHENYL-7H-PYR
- 7-Cyclopentyl-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
- RK-24466 ;RK 24466 ;RK24466
- Lck Inhibitor - CAS 213743-31-8 - Calbiochem
- d]pyrimidin-4-ylamine
- RK-24466
- KIN 001-51
- 7H-Pyrrolo[2,3-d]pyrimidin-4-amine, 7-cyclopentyl-5-(4-phenoxyphenyl)-
- KIN001-051
- RK-24466,Src,Inhibitor,inhibit,RK 24466,RK24466
- 4-Amino-7-cyclopentyl-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidine
- RK-24466, 10 mM in DMSO
- 213743-31-8
- LckNon-Receptor Tyrosine Kinase Biology
- Lymphocyte Specific Kinase (Lck)Cell Signaling and Neuroscience
- Non-Receptor Tyrosine Kinase Inhibitors
- Enzyme Inhibitors by Enzyme
- Kinase/Phosphatase Biology
- L to
- Protein Kinase Inhibitors
