RS 102895

300815-41-2

CAS-Nr.: 300815-41-2

Englisch Name:: RS 102895

Synonyma:: RS 102895 HYDROCHLORIDE;1'-(4-(trifluoromethyl)phenethyl)spiro[benzo[d][1,3]oxazine-4,4'-piperidin]-2(1H)-one;RS102895, 10 mM in DMSO;CC chemokine receptor,CCR,Inhibitor,RS102895,inhibit,RS-102895,RS 102895;1'-[2-[4-(trifluoromethyl)phenyl]ethyl]-spiro[4h-3,1-benzoxazine-4,4'-peperidin]-2(1h)-one;Spiro[4H-3,1-benzoxazine-4,4'-piperidin]-2(1H)-one, 1'-[2-[4-(trifluoromethyl)phenyl]ethyl]-;1'-(4-(TrifluoroMethyl)phenethyl)spiro[benzo[d][1,3]oxazine-4,4'-piperidin]-2(1H)-one hydrochloride;1'-[2-[4-(trifluoromethyl)phenyl]ethyl]spiro[1H-3,1-benzoxazine-4,4'-piperidine]-2-one,hydrochloride;1'-[2-[4-(TRIFLUOROMETHYL)PHENYL]ETHYL]-SPIRO[4H-3,1-BENZOXAZINE-4,4'-PIPERIDIN]-2(1H)-ONE HYDROCHLORIDE

CBNumber:: CB6504368

Summenformel:: C21H21F3N2O2

Molgewicht:: 390.4

MOL-Datei:: 300815-41-2.mol

Request For Quotation

Eigenschaften Sicherheit Verwendungswort Produktionsfirma 113

RS 102895 Eigenschaften

Siedepunkt:: 446.1±45.0 °C(Predicted)

Dichte: 1.33±0.1 g/cm3 (20 ºC 760 Torr)

storage temp.: Desiccate at RT

L?slichkeit: DMSO: 18 mg/mL, clear, colorless

Aggregatzustand: powder

pka: 13.46±0.20(Predicted)

Farbe: white

InChI: 1S/C21H21F3N2O2.ClH/c22-21(23,24)16-7-5-15(6-8-16)9-12-26-13-10-20(11-14-26)17-3-1-2-4-18(17)25-19(27)28-20;/h1-8H,9-14H2,(H,25,27);1H

InChIKey: KRRISOFSWVKYBF-UHFFFAOYSA-N

SMILES: Cl.FC(F)(F)c1ccc(CCN2CCC3(CC2)OC(=O)Nc4ccccc34)cc1

Sicherheit

S-S?tze:	22-24/25
WGK Germany	3
Speicherklasse	11 - Combustible Solids

RS 102895 Chemische Eigenschaften,Einsatz,Produktion Methoden

S-S?tze Betriebsanweisung:

S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.

Verwenden

RS 102895 is a CCR2-selective chemokine receptor inhibitor.

Biologische Aktivit?t

CCR2-selective chemokine receptor antagonist (IC 50 values are 0.36 and 17.8 μ M for inhibition of human recombinant CCR2b and CCR1 receptors respectively). Blocks MCP-1-stimulated calcium influx and chemotaxis with IC 50 values of 32 nM and 1.7 μ M respectively. Also inhibits α 1A , α 1D and 5-HT 1A receptors.

RS 102895 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

RS 102895 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 113)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Shanghai UCHEM Inc.	+862156762820 +86-13564624040	sales@myuchem.com	China	8811	58
Hefei Hirisun Pharmatech Co., Ltd	+8615056975894	shawn@hirisunpharm.com	CHINA	9911	58
Henan Aochuang Chemical Co.,Ltd.	+86-0371-63689365 +8618638391208	sales@aochuangchem.com	China	9333	58
TargetMol Chemicals Inc.	+1-781-999-5354;	support@targetmol.com	United States	39039	58
Zibo Hangyu Biotechnology Development Co., Ltd	+86-0533-2185556 +8615965530500	nickzhang@hangyubiotech.com	China	9947	58
HANGZHOU LEAP CHEM CO., LTD.	+86-571-87711850	market18@leapchem.com	China	43333	58
Jilin Chinese Academy of Sciences-yanshen Technology	+undefined18143011203	info@chemextension.com	China	42056	58
Aladdin Scientific		tp@aladdinsci.com	United States	57505	58
DAYANG CHEM (HANGZHOU) CO.,LTD	+86-88938639 +86-17705817739	info@dycnchem.com	China	53803	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131956	58

1'-(4-(TrifluoroMethyl)phenethyl)spiro[benzo[d][1,3]oxazine-4,4'-piperidin]-2(1H)-one hydrochloride
1'-[2-[4-(trifluoromethyl)phenyl]ethyl]-spiro[4h-3,1-benzoxazine-4,4'-peperidin]-2(1h)-one
1'-[2-[4-(TRIFLUOROMETHYL)PHENYL]ETHYL]-SPIRO[4H-3,1-BENZOXAZINE-4,4'-PIPERIDIN]-2(1H)-ONE HYDROCHLORIDE
1'-[2-[4-(trifluoromethyl)phenyl]ethyl]spiro[1H-3,1-benzoxazine-4,4'-piperidine]-2-one,hydrochloride
Spiro[4H-3,1-benzoxazine-4,4'-piperidin]-2(1H)-one, 1'-[2-[4-(trifluoromethyl)phenyl]ethyl]-
1'-(4-(trifluoromethyl)phenethyl)spiro[benzo[d][1,3]oxazine-4,4'-piperidin]-2(1H)-one
CC chemokine receptor,CCR,Inhibitor,RS102895,inhibit,RS-102895,RS 102895
RS102895, 10 mM in DMSO
RS 102895 HYDROCHLORIDE
300815-41-2
C21H21F3N2O2HCl
RS 102895 CCR2-selective chemokine receptor antagonist.
Cytokine signaling

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