EMEDASTINE FUMARATE
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- CAS-Nr.
- 87233-62-3
- Englisch Name:
- EMEDASTINE FUMARATE
- Synonyma:
- Emadine;Emestine Fumarate;1-(2-ethoxyethyl)-2-(4-methyl-1-homopiperazinyl)benzimidazoledifumarate;Daren;kb2413;Remicut;kb-2413;kg-2413;AL 3432A;Rapimine
- CBNumber:
- CB6714475
- Summenformel:
- C25H34N4O9
- Molgewicht:
- 534.56
- MOL-Datei:
- 87233-62-3.mol
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EMEDASTINE FUMARATE Eigenschaften
- Schmelzpunkt:
- 148-151°
- storage temp.
- 2-8°C
- L?slichkeit
- Soluble in water, sparingly soluble in anhydrous ethanol, very slightly soluble in acetone.
- Merck
- 14,3557
- Major Application
- pharmaceutical (small molecule)
- InChIKey
- FWLKKPKZQYVAFR-LVEZLNDCSA-N
- SMILES
- C1(=NC2C=CC=CC=2N1CCOCC)N1CCN(C)CCC1.C(/C(=O)O)=C\C(=O)O.C(/C(=O)O)=C\C(=O)O
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| WGK Germany |
WGK 3 |
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| RTECS-Nr. |
DD8870000 |
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| HS Code |
2933992600 |
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| Speicherklasse |
11 - Combustible Solids |
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| Hazard Classifications |
Acute Tox. 4 Oral |
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| Toxizit?t |
LD50 orally in guinea pigs: 744 mg/kg (Fukuda) |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
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P264, P270, P301+P312, P330, P501 |
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| Sicherheit |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P270 |
Bei Gebrauch nicht essen, trinken oder rauchen. |
| P501 |
Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen. |
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EMEDASTINE FUMARATE Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Emedastine difumarate, a potent H
1-receptor antagonist, was launched in Japan for the
treatment of allergic rhinitis and urticaria. Emedastine exerts its antiallergic effect via
inhibition of substance P-induced histamine release. It has been demonstrated both in vitro
and in vivo that this effect is mediated by the inhibition of Ca
2+release from extracellular
stores and of Ca
2+ influx into mast cells. In a clinical trial with bronchial asthma, emedastine
improved asthmatic symptoms in 55.3% of patients.
Chemische Eigenschaften
White or yellowish powder
Verwenden
Antihistaminic, H1-receptor; asthma prophylactic;
anti-allergic.
Definition
ChEBI: The fumaric acid salt of emedastine containing two molecules of fumaric acid for each molecule of emedastine. A relatively selective histamine H1 antagonist, it is used for allergic rhinitis, urticaria, and pruritic skin disorders, and
in eyedrops for the symptomatic relief of allergic conjuntivitis.
Hazard
A poison by ingestion.
EMEDASTINE FUMARATE Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
EMEDASTINE FUMARATE Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 177)Lieferanten
- 1-(2-ethoxyethyl)-2-(4-methylhexahydro-1h-1,4-diazepin-1-yl)-benzimidazol
- 1-(2-ethoxyethyl)-2-(4-methylhexahydro-1h-1,4-diazepin-1-yl)benzimidazolefum
- 1-(2-Ethoxyethyl)-2-(4-methylhexahydro-1H-1,4-diazepine-1-yl)-1H-benzimidazole·bisfumaric acid
- Daren
- Emedastin difumarate
- Emedastin fumarate
- Remicut
- Emedastine Difumarate (100 mg)
- Rapimine
- AL 3432A
- 1-(2-Ethoxyethyl)-2-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-1H-benzimidazole (2E)-2-butenedioate (1:2)
- 1h-benzimidazole,1-(2-ethoxyethyl)-2-(hexahydro-4-methyl-1h-1,4-diazepin-1-yl)
- arate(1:2)
- emedastinedifumarate
- kb2413
- kb-2413
- kg-2413
- ly188695
- EMEDASTINE FUMARATE
- 1-(2-ethoxyethyl)-2-(4-methyl-1,4-diazepan-1-yl)-1H-benzo[d]imidazole difumarate
- EmedastineDifumarate>
- Emedastine difumarate CRS
- 1-(2-Ethoxyethyl)-2-(4-methylhexahydro-1H-1,4-diazepin-1- yl)-1H-benzimidazole bis[hydrogen (2E)-butenedioate
- Emedastine Difumarate (1234806)
- 1-(2-ethoxyethyl)-2-(4-methyl-1-homopiperazinyl)benzimidazoledifumarate
- Emadine
- Fmedastine Difumarate
- 1H-Benzimidazole, 1-(2-ethoxyethyl)-2-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-, (2E)-2-butenedioate (1:2)
- Emestine Fumarate
- 87233-62-3
- C25H34N4O9
- C17H26N4O2C4H4O4
