(R)-CPP
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- CAS-Nr.
- 126453-07-4
- Englisch Name:
- (R)-CPP
- Synonyma:
- D-CPP;(R)-CCP;(R)-CPP;CPP (R)-;(R)CPP,(R) CPP;(R)-CPP, NMDA antagonist;(R)-CPP (mM/ml), NMDA antagonist;rac-(S*)-2-(2,4-Dichlorophenoxy)propanoic acid;rac-(2R*)-2-(2,4-Dichlorophenoxy)propionic acid;rac-(2R*)-2-(2,4-Dichlorophenoxy)propanoic acid
- CBNumber:
- CB6725314
- Summenformel:
- C8H17N2O5P
- Molgewicht:
- 252.2
- MOL-Datei:
- 126453-07-4.mol
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(R)-CPP Eigenschaften
- Siedepunkt:
- 546.7±60.0 °C(Predicted)
- Dichte
- 1.408±0.06 g/cm3(Predicted)
- storage temp.
- Desiccate at RT
- L?slichkeit
- Water: 100mM
- Aggregatzustand
- White crystalline powder.
- pka
- 1.89±0.20(Predicted)
- Farbe
- White to off-white
- Wasserl?slichkeit
- Soluble to 100 mM in water
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
(R)-CPP Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
(R)-CPP is an NMDA receptor antagonist (K
i = 0.14 μM). It binds to NMDA receptors containing GluN2A, GluN2B, GluN2C, and GluN2D subunits with K
i values of 0.04, 0.3, 0.6, and 2 μM, respectively. It inhibits depolarization induced by NMDA in isolated hemisected frog spinal cord (pA
2 = 6.56) and NMDA-induced sodium efflux from rat brain slices (pA
2 = 6.2). (R)-CPP inhibits the clonic phase of sound-induced seizures in DBA/2 mice (ED
50 = 65.8 μmol/kg) and the myoclonic phase of stroboscopic-induced seizures in
P. papio photosensitive baboons (ED
50 = 127 μmol/kg).
Verwenden
(R)-CPP is a piperazine derivative demonstrating highly potent NMDA receptor antagonism.
Biologische Aktivit?t
Highly potent NMDA antagonist; more active isomer. Shows some selectivity for NR2A-containing receptors (K i values are 0.041, 0.27, 0.63 and 1.99 μ M for inhibition of NR2A-, NR2B-, NR2C- and NR2D-containing recombinant NMDA receptors respectively).
(R)-CPP Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
(R)-CPP Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 78)Lieferanten
126453-07-4()Verwandte Suche:
- (R)-CPP
- (R)-CCP
- R(-)-3-(2-CARBOXYPIPERAZIN-4-YL)-PROPYL-1-PHOSPHONIC ACID
- D-CPP
- 3-((R)-2-CARBOXYLPIPERAZIN-4-YL)-PROPYL-1-PHOSPHONIC ACID
- 3-((R)-2-CARBOXYPIPERAZIN-4-YL)-PROPYL-1-PHOSPHONIC ACID
- 3-((R)-Carboxylpiperazin-4-yl)-propyl-1-phosphonic acid
- rac-(2R*)-2-(2,4-Dichlorophenoxy)propanoic acid
- rac-(2R*)-2-(2,4-Dichlorophenoxy)propionic acid
- rac-(S*)-2-(2,4-Dichlorophenoxy)propanoic acid
- [3-[(2R)-2-Carboxypiperazin-4-yl]propyl]phosphonic acid
- 3-[(2R)-2-Carboxypiperazine-4-yl]propane-1-ylphosphonic acid
- CPP (R)-
- 2-Piperazinecarboxylic acid, 4-(3-phosphonopropyl)-, (2R)-
- (R)-4-(3-phosphonopropyl)piperazine-2-carboxylic acid
- (R)CPP,(R) CPP
- (R)-CPP, NMDA antagonist
- (R)-CPP (mM/ml), NMDA antagonist
- 126453-07-4
- C8H17N2O5P
- Glutamate
- Glutamate receptor
