7(S)-Hydroxy-16(R)-methyl-10-phenyl-24-oxa(14)cytochalasa-6(12),13(E),21(E)-trien-1,20,23-trion
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- CAS-Nr.
- 14110-64-6
- Bezeichnung:
- 7(S)-Hydroxy-16(R)-methyl-10-phenyl-24-oxa(14)cytochalasa-6(12),13(E),21(E)-trien-1,20,23-trion
- Englisch Name:
- CYTOCHALASIN A
- Synonyma:
- Dehydrophomin;CYTOCHALASIN A;CYTOCHALASIN A(RG);5,5-Didehydrophomin;Cytochalasin dreschslera dematioidea;CYTOCHALASIN A FROM DRESCHSLERA DEMATIOIDEA;CytochalasinA from Drechslera dematioidea;cytochalasin a from helminthosporium dematioideum;Cytochalasin A from Drechslera dematioidea;Cytochalasin A 5-Dehydrophomin Dehydrophomin
- CBNumber:
- CB6735221
- Summenformel:
- C29H35NO5
- Molgewicht:
- 477.59
- MOL-Datei:
- 14110-64-6.mol
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7(S)-Hydroxy-16(R)-methyl-10-phenyl-24-oxa(14)cytochalasa-6(12),13(E),21(E)-trien-1,20,23-trion Eigenschaften
- Schmelzpunkt:
- 190-191 °C
- Siedepunkt:
- 725.1±60.0 °C(Predicted)
- Dichte
- 1.20±0.1 g/cm3(Predicted)
- storage temp.
- -20°C
- L?slichkeit
- ethanol: 20 mg/mL, clear, colorless
- pka
- 13.54±0.70(Predicted)
- Aggregatzustand
- Powder
- Farbe
- White
- Wasserl?slichkeit
- Soluble in DMF, DMSO, ethanol and acetone. Insoluble in water.
- Sensitive
- Light Sensitive
- BRN
- 949521
- InChIKey
- ZMAODHOXRBLOQO-TZVKRXPSSA-N
- SMILES
- C[C@@H]1CCCC(=O)\C=C\C(=O)O[C@]23[C@@H](\C=C\C1)[C@H](O)C(=C)[C@@H](C)[C@H]2[C@H](Cc4ccccc4)NC3=O
- LogP
- 1.849 (est)
- EPA chemische Informationen
- Cytochalasin A (14110-64-6)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Kennzeichnung gef?hrlicher |
T+,T |
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| R-S?tze: |
26/27/28-63 |
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| S-S?tze: |
28-36/37-45 |
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| RIDADR |
UN 1544 6.1/PG 2 |
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| WGK Germany |
3 |
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| F |
10 |
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| HazardClass |
6.1(a) |
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| PackingGroup |
I |
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| HS Code |
29349990 |
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| Speicherklasse |
6.1A - Combustible acute toxic Cat. 1 and 2
very toxic hazardous materials |
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| Hazard Classifications |
Acute Tox. 1 Inhalation
Acute Tox. 2 Dermal
Acute Tox. 2 Oral
Repr. 2 |
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| Bildanzeige (GHS) |
 
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| Alarmwort |
Achtung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H361 |
Kann vermutlich die Fruchtbarkeit beeintr?chtigen oder das Kind im Mutterleib sch?digen. |
Reproduktionstoxizit?t |
Kategorie 2 |
Warnung |
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P201, P202, P281, P308+P313, P405,P501 |
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| Sicherheit |
| P201 |
Vor Gebrauch besondere Anweisungen einholen. |
| P202 |
Vor Gebrauch alle Sicherheitshinweise lesen und verstehen. |
| P260 |
Dampf/Aerosol/Nebel nicht einatmen. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
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7(S)-Hydroxy-16(R)-methyl-10-phenyl-24-oxa(14)cytochalasa-6(12),13(E),21(E)-trien-1,20,23-trion Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R26/27/28:Sehr giftig beim Einatmen, Verschlucken und Berührung mit der Haut.
R63:Kann das Kind im Mutterleib m?glicherweise sch?digen.
S-S?tze Betriebsanweisung:
S28:Bei Berührung mit der Haut sofort abwaschen mit viel . . . (vom Hersteller anzugeben).
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn m?glich, dieses Etikett vorzeigen).
Beschreibung
The cytochalasins are cell-
permeable fungal metabolites which inhibit actin polymerization. This interferes with such diverse processes as cell movement, growth, phagocytosis, degranulation, and secretion. Cytochalasin A is an oxidized analog of cytochalasin B which uniquely inhibits HIV-
1 protease (IC
50 = 3 μM). Cytochalasins A and B differ from other cytochalasins in being able to rapidly and reversibly inhibit glucose transport by competitively binding glucose transporters (K
i = 4.0 and 0.6 μM, respectively). Cytochalasin A also induces the phosphorylation of the tyrosine phosphatase PTP3 of
Dictyostelium, activating STATc.
Chemische Eigenschaften
white powder
Verwenden
Cytochalasin A is one of a family of potent mycotoxins produced by several species of fungi. All members of the class exhibit profound effects on cytoskeletal proteins, giving rise to pronounced morphogenic activity in animals and plants. Like most cytochalsins, cytochalasin A exhibits potent inhibition of actin filament function leading to cell death by apoptosis, and displays a broad range of resultant cellular actions. Despite the common mode of action, there is evidence that individual members of the class display diverse selectivity. Specifically, cytochalasin A is one of the few cytochalasins exhibiting activity against HIV-1 protease.
7(S)-Hydroxy-16(R)-methyl-10-phenyl-24-oxa(14)cytochalasa-6(12),13(E),21(E)-trien-1,20,23-trion Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
7(S)-Hydroxy-16(R)-methyl-10-phenyl-24-oxa(14)cytochalasa-6(12),13(E),21(E)-trien-1,20,23-trion Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 114)Lieferanten
14110-64-6(7(S)-Hydroxy-16(R)-methyl-10-phenyl-24-oxa(14)cytochalasa-6(12),13(E),21(E)-trien-1,20,23-trion)Verwandte Suche:
7(S),18-Dihydroxy-16(S),18(R)-dimethyl-10-phenyl[11]cytochalasa-5,13(E),19(E)-trien-1,17-dion-21(R)-acetat
7(S),18(R)-Dihydroxy-16(S),18-dimethyl-10-phenyl[11]cytochalasa-6(12),13(E),19(E)-trien-1,17-dion-21(R)-acetat
7(S),20(R)-Dihydroxy-16(R)-methyl-10-phenyl-24-oxa(14)cytochalasa-6(12),13(E),21(E)-trien-1,23-dion
21,23-Dioxa(13)cytochalasa-13,19-dien-1,17,22-trion, 6,7-epoxy-18-hydroxy-16,18-dimethyl-10-phenyl-,(7S,13E,16S,18R,19E)-
2-(Pentylamino)ethanol
2,5-Dimethylcyclohexan-1-ol
Octa-1,7-dien
Pent-4-en-1-ol
7(S)-Hydroxy-16(R)-methyl-10-phenyl-24-oxa(14)cytochalasa-6(12),13(E),21(E)-trien-1,20,23-trion
1,3-Dimethylpentylamin
Lactamid
Oct-2-ensure
Valpromid
Isopentylbenzol
2-Ethyl-1-butanamin
2-Methylpropylacrylat
Hexylacrylat
Cyclohexylacrylat
- (7S,13E,16R,21E)-7-Hydroxy-16-methyl-10-phenyl-24-oxa[14]cytochalasa-6(12),13,21-triene-1,20,23-trione
- 5,5-Didehydrophomin
- Dehydrophomin
- Cytochalasin dreschslera dematioidea
- Cytochalasin A 5-Dehydrophomin Dehydrophomin
- 7(S)-hydroxy-16(R)-methyl-10-phenyl-24-oxa[14]cytochalasa-6(12),13(E),21(E)-triene-1,20,23-trione
- 2H-Oxacyclotetradecino2,3-disoindole-2,5,18-trione, 6,7,8,9,10,12a,13,14,15,15a,16,17-dodecahydro-13-hydroxy-9,15-dimethyl-14-methylene-16-(phenylmethyl)-, (3E,9R,11E,12aS,13S,15S,15aS,16S,18aS)-
- CYTOCHALASIN A FROM DRESCHSLERA DEMATIOIDEA
- CYTOCHALASIN A FROM DRESCHSLERA DEMATIOIDEA, BIOCHEMIKA, >= 99.0% (TLC)
- CYTOCHALASIN A
- cytochalasin a from helminthosporium dematioideum
- CYTOCHALASIN A(RG)
- CytochalasinA from Drechslera dematioidea
- Cytochalasin A from Drechslera dematioidea
- 14110-64-6
- C29H35NO5
- Other
- Cytoskeleton and Extracellular Matrix
- Enzymes, Inhibitors, and Substrates
- Enzyme Inhibitors
- Enzyme Inhibitors by Type
- Cell Biology
- Cell Signaling and Neuroscience
- Biochemicals and Reagents
- BioChemical
- Actin Inhibitors and Probes
- Actin Inhibitors and ProbesCell Signaling and Neuroscience
- Cell Signaling and Neuroscience
- antibiotic
- Cytoskeleton and Extracellular Matrix
- Mold
- Toxins and Venoms
