PD158780
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- CAS-Nr.
- 171179-06-9
- Englisch Name:
- PD158780
- Synonyma:
- PD 158780 solution;PD 158780; PD-158780;InSolution? PD 158780;PD158780, 10 mM in DMSO;PD 158780 - CAS 171179-06-9 - Calbiochem;PD 158780, ErbB receptor tyrosine kinase inhibitor;InSolution PD 158780 - CAS 171179-06-9 - Calbiochem;N4-(3-Bromophenyl)-N6-methylpyrido[3,4-d]-4,6-pyrimidinediamine;N4-(3-Bromophenyl)-N6-methyl-pyrido[3,4-d]pyrimidine-4,6-diamine;Pyrido[3,4-d]pyriMidine-4,6-diaMine,N4-(3-broMophenyl)-N6-Methyl-
- CBNumber:
- CB71074528
- Summenformel:
- C14H12BrN5
- Molgewicht:
- 330.18
- MOL-Datei:
- 171179-06-9.mol
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PD158780 Eigenschaften
- Schmelzpunkt:
- 174.0 to 178.0 °C
- Siedepunkt:
- 499.6±45.0 °C(Predicted)
- Dichte
- 1.611±0.06 g/cm3 (20 ºC 760 Torr)
- storage temp.
- Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
- L?slichkeit
- DMSO: ≥20mg/mL
- Aggregatzustand
- Yellow solid
- pka
- 5.80±0.30(Predicted)
- Farbe
- yellow
- InChI
- 1S/C14H12BrN5/c1-16-13-6-11-12(7-17-13)18-8-19-14(11)20-10-4-2-3-9(15)5-10/h2-8H,1H3,(H,16,17)(H,18,19,20)
- InChIKey
- KFHMLBXBRCITHF-UHFFFAOYSA-N
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Kennzeichnung gef?hrlicher |
Xn |
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| R-S?tze: |
22 |
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| WGK Germany |
WGK 2 |
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| HS Code |
2912.49.2600 |
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| Speicherklasse |
10 - Combustible liquids |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
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P264, P270, P301+P312, P330, P501 |
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| Sicherheit |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P270 |
Bei Gebrauch nicht essen, trinken oder rauchen. |
| P301+P312 |
BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen. |
| P330 |
Mund ausspülen. |
| P501 |
Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen. |
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PD158780 Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
PD 158780 is a potent tyrosine kinase inhibitor of the epidermal growth factor receptor and has been shown to delay substantial growth of tumors in vivo tumor models.
Allgemeine Beschreibung
A potent inhibitor of the EGFR tyrosine kinase activity (8 pM). Also inhibits heregulin-stimulated autophosphorylation in SK-BR-3 (IC
50 =49 nM) and MDA-MB-453 (IC
50 = 52 nM) breast carcinomas. The inhibition is competitive and results from binding of the inhibitor at the ATP site of the enzymes. Inhibits the LPA-stimulated MAP kinase kinase 1/2 (MKK1/2) activation and EGFR tyrosine phosphorylation in HeLa and NIH3T3 cells.
Biologische Aktivit?t
Potent inhibitor of ErbB receptor family tyrosine kinases (IC 50 values are 0.008, 49 and 52 nM for EGFR, ErbB2 and ErbB2/ErbB4 respectively) that does not inhibit FGF or PDGF-mediated tyrosine phosphorylation. Induces G 1 cell cycle arrest in MCF10A cells and is antiproliferative in A431 human epidermal carcinoma cells.
PD158780 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
PD158780 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 86)Lieferanten
171179-06-9()Verwandte Suche:
- N4-(3-Bromophenyl)-N6-methyl-pyrido[3,4-d]pyrimidine-4,6-diamine
- Pyrido[3,4-d]pyriMidine-4,6-diaMine,N4-(3-broMophenyl)-N6-Methyl- (Related Reference)
- Pyrido[3,4-d]pyriMidine-4,6-diaMine,N4-(3-broMophenyl)-N6-Methyl-
- PD 158780 solution
- InSolution? PD 158780
- PD 158780 - CAS 171179-06-9 - Calbiochem
- InSolution PD 158780 - CAS 171179-06-9 - Calbiochem
- PD 158780; PD-158780
- PD158780,Inhibitor,Epidermal growth factor receptor,inhibit,HER1,EGFR,PD 158780,ErbB-1,PD-158780
- PD 158780, ErbB receptor tyrosine kinase inhibitor
- PD158780, 10 mM in DMSO
- N4-(3-Bromophenyl)-N6-methylpyrido[3,4-d]-4,6-pyrimidinediamine
- 171179-06-9
