GW9508
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- CAS-Nr.
- 885101-89-3
- Englisch Name:
- GW9508
- Synonyma:
- GW9508;CS-618;GPR40 Agonist;GW9508, >=99%;GW9508 USP/EP/BP;885101-89-3(GW9508);GW9508, 10 mM in DMSO;GW-9508;GW9508;GW 9508;GPR40 Agonist GW9508 GW-9508;GW 9508, FFA1 receptor agonist
- CBNumber:
- CB71074937
- Summenformel:
- C22H21NO3
- Molgewicht:
- 347.41
- MOL-Datei:
- 885101-89-3.mol
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GW9508 Eigenschaften
- Schmelzpunkt:
- 90-92°C
- Siedepunkt:
- 538.4±45.0 °C(Predicted)
- Dichte
- 1.222±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- L?slichkeit
- DMSO: >20mg/mL
- Aggregatzustand
- white powder
- pka
- 4.77±0.10(Predicted)
- Farbe
- Off-white
- Stabilit?t:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
- InChI
- 1S/C22H21NO3/c24-22(25)14-11-17-9-12-19(13-10-17)23-16-18-5-4-8-21(15-18)26-20-6-2-1-3-7-20/h1-10,12-13,15,23H,11,14,16H2,(H,24,25)
- InChIKey
- DGENZVKCTGIDRZ-UHFFFAOYSA-N
- SMILES
- OC(=O)CCc1ccc(NCc2cccc(Oc3ccccc3)c2)cc1
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
  
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| Alarmwort |
Achtung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
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P264, P270, P301+P312, P330, P501 |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
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P264, P280, P302+P352, P321,P332+P313, P362 |
| H318 |
Verursacht schwere Augensch?den. |
Schwere Augensch?digung |
Kategorie 1 |
Achtung |
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P280, P305+P351+P338, P310 |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizit?t (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
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| H410 |
Sehr giftig für Wasserorganismen mit langfristiger Wirkung. |
Langfristig (chronisch) gew?ssergef?hrdend |
Kategorie 1 |
Warnung |
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P273, P391, P501 |
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| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P273 |
Freisetzung in die Umwelt vermeiden. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
| P501 |
Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen. |
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GW9508 Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
GW9508 is a GPR40 full agonist, used to regulate glucose in rats. Can be applied to the treatment of diabetes type 2. GPR120 selective and potent agonist also used in the treatment of diabetes type 2 due to GPR120’s ability to mediate GLP-1 secretion, insulin sensitization and anti-obesity effects.
Biologische Aktivit?t
Potent and selective agonist for the free fatty acid receptor FFA 1 (GPR40) (pEC 50 values are 7.32, < 4.3 and < 4.3 for FFA 1 , FFA 2 and FFA 3 receptors respectively). Inactive against a range of other GPCRs, kinases, proteases, integrins and PPARs. Potentiates glucose-stimulated insulin secretion in MIN6 cells (pEC 50 = 6.14).
Biochem/physiol Actions
GW9508 is a selective FFA1/GPR40 agonist. GPR40 was formerly an orphan G protein-coupled receptor whose endogenous ligands have now been identified as free fatty acids (FFAs). The receptor, named FFA receptor 1, has been implicated in the pathophysiology of type 2 diabetes and is a drug target because of its role in FFA-mediated enhancement of glucose-stimulated insulin release. GW9508 showed greater than 500-fold selectivity for GPR40 over GPR41 and GPR43 and possessed a good in vitro and in vivo profile with excellent bioavailability. GW9508 stimulated intracellular Ca2+ mobilization in human embryonic kidney HEK-293 cells expressing GPR40 or GPR120, but not in the parent HEK-293 cell line. GW9508 dose dependently potentiated glucose-stimulated insulin secretion in MIN6 cells, but not in primary rat or mouse islets. GW9508 potentiates the KCl-mediated increase in insulin secretion in MIN6 cells.
GW9508 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
GW9508 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 173)Lieferanten
- GW9508
- 4-[[(3-Phenoxyphenyl)methyl]amino]benzenepropanoicacid
- 3-(4-((3-Phenoxybenzyl)aMino)phenyl)propanoic acid
- 885101-89-3(GW9508)
- GW9508, >=99%
- Benzenepropanoic acid, 4-[[(3-phenoxyphenyl)methyl]amino]-
- 4-[[(3-Phenoxyphenyl)methyl]amino]benzenepropanoic acid GW9508
- GW 9508 4-[[(3-Phenoxyphenyl)methyl]amino]benzenepropanoic acid
- 4-(3-Phenoxybenzylamino)phenylpropionic acid
- GPR40 Agonist
- 3-[4-[(3-phenoxyphenyl)methylamino]phenyl]propanoic acid
- GPR40 Agonist - CAS 885101-89-3 - Calbiochem
- GW-9508;GW9508;GW 9508
- CS-618
- GW9508 USP/EP/BP
- GPR40 Agonist GW9508 GW-9508
- GW 9508, FFA1 receptor agonist
- GW9508, 10 mM in DMSO
- 4-[[(3-phenoxyphenyl)methyl]amino]phenylacetic acid
- 885101-89-3
- Inhibitors
