di-tert-butylazodicarboxylat Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R11:Leichtentzündlich.

S-S?tze Betriebsanweisung:

S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S16:Von Zündquellen fernhalten - Nicht rauchen.

Chemische Eigenschaften

yellow crystals or crystalline powder

Verwenden

Di-tert-butyl azodicarboxylate is a reagent used in the preparation of acyl hydrazinedicarboxylates. It is also used in the electrophilic amination of beta-keto esters catalyzed by an axially chiral guanidine. It serves as a precursor in an enantioselective synthesis of 3,6-dihyropyridazines employing organocatalysts such as L-proline or (S)-2-pyrrolidinyl tetrazole. It is also utilized in the asymmetric Friedel-Crafts amination through a chiral organocatalyst. Further, it acts as a reactant for preparation of hexapeptide key fragments through stereo selective selenocyclization/oxidative deselenylation reactions. In addition to this, it is employed as a starting material in the synthesis of pyrroloisoquinoline template through stereoselective N-acyliminium-mediated cyclization and enolate amination for preparation of peptidomimetic compounds and Barbier-type propargylation reactions.

Allgemeine Beschreibung

Di-tert-butyl azodicarboxylate is a an acid labile reagent for Mitsunobu reactions allowing facile isolation of products and for the electrophilic amination and hydrazination of enolates and lithium alkyls.

l?uterung methode

The tert-butyl ester has the advantage over the ethyl ester (below) in being a solid and more acid labile. It crystallises from ligroin and is best purified by covering the dry solid (22g) with pet ether (b 30-60o, 35-40 mL) heating to boiling and adding ligroin (b 60-90o) until the solid dissolves. On cooling, large lemon yellow crystals of the ester separate (~ 20g), m 90.7-92o. Evaporation of the filtrate gives a further crop of crystals [Carpino & Crowley Org Synth 44 18 1964]. This reagent is useful in the Mitsunobu reaction [Mitsunobu Synthesis 1 1981, Gennari et al. J Am Chem Soc 108 6394 1986, Evans et al. J Am Chem Soc 108 6394 1986, Hughes Org React 42 335 1992, Dodge et al. Org Synth 73 110 1996, Hughes Org Prep Proc Int 28 127 1996, Ferguson & Marcelle J Am Chem Soc 128 4576 2006, see also DEAD and DIAD below].

di-tert-butylazodicarboxylat Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

di-tert-butylazodicarboxylat Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Nanjing Shunxiang Pharmaceutical Technology Co.,Ltd.	+86-025-86819862 +86-13913839793	sales@jinchemical.com	China	29	58
Suzhou Highfine Biotech Co.,Ltd.	+86-0512-68071238 +86-13771819922	june@highfine.com	China	491	58
Ningxia LabsChem Co., Ltd.	0952-9294929 +8613895679378	48472788@qq.com	China	352	58
Hebei Chuanghai Biotechnology Co., Ltd	+86-17732866630	mina@chuanghaibio.com	China	18126	58
Hebei Zhuanglai Chemical Trading Co.,Ltd	13343047651	admin@zlchemi.com	China	3692	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29640	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-2158073036	info@dakenam.com	China	14026	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21585	55
Shanghai Time Chemicals CO., Ltd.	+86-021-57951555 +8618017249410	jack.li@time-chemicals.com	China	1803	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60

870-50-8(di-tert-butylazodicarboxylat)Verwandte Suche:

---

• Di-tert-butyl azodicarboxylate SynonyMs Azodicarboxylic acid di-tert-butyl ester
• Bis(1,1-dimethylethyl)azodicarboxylate
• NSC 109889
• DI-TERT-BUTYL AZODICARBOXYALTE
• Di-tert-butyl azodicarboxylate, 98% 5GR
• Di-Tert-ButylAzodicarboxylate(Dbad)
• Di-(tert-butyl) diazene-1,2-dicarboxylate 98%
• Di-tert-butyl azodicarboxylate purum, >=98.0% (GC)
• Di-tert-butyl azodicarboxylate≥ 98.0% (GC)
• Azodicarboxylic acid di-tert-butyl ester
• DI-TERT-BUTYL AZODICARBOXYLATE
• Di-tert-butyl Azodicarboxylate (20% in Toluene)
• Di-tert-B-butyl azodicarboxylate, 98%
• 1,2-Bis(tert-butoxycarbonyl)diazene
• Azobis(formic acid tert-butyl) ester
• Bis(tert-butoxycarbonyl)diazene
• Diazene-1,2-bis(formic acid tert-butyl) ester
• Diazene-1,2-dicarboxylic acid di-tert-butyl ester
• Diazenedicarboxylic acid bis-tert-butyl ester
• Di-tert-butyl azodicarboxylate,98%
• Di-tert-butyl azodicarboxylate 98%
• 1,2-Diazenedicarboxylic acid, 1,2-bis(1,1-dimethylethyl) ester
• Di-tert-butyl azodicarboxylate, 98%, for synthesis
• N-{[(tert-butoxy)carbonyl]imino}(tert-butoxy)form amide
• SKL270
• tert-butyl N-tert-butoxycarbonyliminocarbamate
• tert-butyl (NE)-N-[(2-methylpropan-2-yl)oxycarbonylimino]carbamate
• Di-tert-butyl azodiformate
• Di-tert-Butyl azodic
• Di-tertiary butyl Azodicarboxylate
• Di-tert-butyl Azodicarboxylate (DTBD)
• Di tert butyl azodicarboxylic acid
• Di-tert-butyl azodicarboxylate
• Di-tert-butyl azodicarboxylate, 95%
• di-tert-butyl (E)-diazene-1,2-dicarboxylate
• Di-tert-butyl diazene-1,2-dicarboxylate
• DI-T-BUTYL AZODICARBOXYLATE
• 870-50-8
• CH33CO2CNNCO2CCH33
• CH33COCONNCOOCCH33
• Mitsunobu
• C-X Bond Formation (Non-Halogen)
• Synthetic Reagents
• C-X Bond Formation (Non-Halogen)
• Mitsunobu
• Synthetic Reagents
• Aliphatics
• Azodicarboxylates & Amides
• Mitsunobu Reaction
• Synthetic Organic Chemistry
• 870-50-8