technetium Tc 99m mebrofenin Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
Radioactive agent.
Allgemeine Beschreibung
Technetium (
99mTc) mebrofenin is a 2:1 complex ofligand:metal that is rapidly eliminated via the hepatobiliarysystem. The presence of bromine within the structureof mebrofenin makes the drug more lipophilic, and thus ithas higher hepatic extraction than other hepatobiliaryiminodiacetic acids (HIDA). Clearance from the blood isalso affected by bilirubin levels, but generally to a muchlesser extent because of the higher hepatic extraction.The clinical indication for this product is hepatobiliaryimaging.
The product is prepared by adding sodium pertechnetate(
99mTc) to the shielded vial containing mebrofenin,stannous fluoride and preservatives, and allowing the mixtureto incubate for 15 minutes. The presence of preservativesallows this kit to be used for up to 18 hours afterpreparation.
The fasting patient receives an intravenous injection of5 mCi (185 MBq), which is taken up by the hepatocytes inthe liver by active anionic transport. Patients with bilirubinlevels greater than 1.5 mg/dL may require a 10 mCi(370 MBq) dose.
technetium Tc 99m mebrofenin Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
