Thiomorpholine-1,1-dioxide
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- CAS-Nr.
- 39093-93-1
- Englisch Name:
- Thiomorpholine-1,1-dioxide
- Synonyma:
- THIOMORPHOLINE 1,1-DIOXIDE;THIOMORPHOLINE DIOXIDE;1,1-DIOXOTHIOMORPHOLINE;DK771;DKSI157;EOS-62289;TIMTEC-BB SBB010267;Thiomorpholine-1,1-oxide;1,1-DioxidothioMorpholine;ThioMorpholine-1,1-dioxid
- CBNumber:
- CB7140484
- Summenformel:
- C4H9NO2S
- Molgewicht:
- 135.18
- MOL-Datei:
- 39093-93-1.mol
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Thiomorpholine-1,1-dioxide Eigenschaften
- Schmelzpunkt:
- 0°C
- Siedepunkt:
- 0°C
- Dichte
- 1.239±0.06 g/cm3(Predicted)
- Flammpunkt:
- 0°C
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- L?slichkeit
- DMSO (Slightly), Methanol (Slightly)
- Aggregatzustand
- Solid
- pka
- 6.48±0.20(Predicted)
- Farbe
- White to Off-White
- InChI
- InChI=1S/C4H9NO2S/c6-8(7)3-1-5-2-4-8/h5H,1-4H2
- InChIKey
- NDOVLWQBFFJETK-UHFFFAOYSA-N
- SMILES
- N1CCS(=O)(=O)CC1
- CAS Datenbank
- 39093-93-1(CAS DataBase Reference)
Thiomorpholine-1,1-dioxide Chemische Eigenschaften,Einsatz,Produktion Methoden
Chemische Eigenschaften
light yellow solid
Verwenden
Thiomorpholine 1,1-Dioxide is a useful building block, used in the synthetic preparation of antibacterial biaryloxazolidinone analogues, and isothiazolo-pyridine derivatives for use as cyclin G-associated kinase inhibitors and antiviral agents.
Synthese
To a solution of tert-butylthiomorpholine-4-carboxylate (5.8 g, 0.024 mol) in dichloromethane (50 ml) was added trifluoroacetic acid (70 ml), and the resulting mixture was stirred at 25°C. 5 hours until TLC showed the reaction was complete. Concentrate under reduced pressure to obtain a mixture. Water (30 mL) was added to the mixture, the mixture was basified to pH=8.0 with aqueous ammonia solution, and the mixture was extracted three times with dichloromethane (50 mLx3). The organic extracts were combined and washed with water and brine. The organic extract was dried over anhydrous magnesium sulfate and filtered, and the filtrate was concentrated under reduced pressure to obtain Thiomorpholine 1,1-dioxide.
Thiomorpholine-1,1-dioxide Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Thiomorpholine-1,1-dioxide Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 257)Lieferanten
39093-93-1()Verwandte Suche:
- TIMTEC-BB SBB010267
- 1,1-DIOXIDE-4-THIOMORPHOLINE
- Thiomorpholine-1,1-oxide
- thiomorpholine 1,1-dioxide(SALTDATA: HCl)
- ThioMorpholine-1,1-dioxid
- 1$l^{6},4-thioMorpholine-1,1-dione
- 1,1-DioxidothioMorpholine
- 1,4-Thiazinane 1,1-dioxide, 1,1-Dioxidothiomorpholine
- EOS-62289
- 1,1-DIOXOTHIOMORPHOLINE
- Thiomorpholine, 1,1-dioxide (7CI, 9CI, ACI)
- DK771
- DKSI157
- THIOMORPHOLINE DIOXIDE
- THIOMORPHOLINE 1,1-DIOXIDE
- 39093-93-1
- 500-57-9
- Heterocycles series
