一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

FOLATES

FOLATES Struktur
CAS-Nr.
Englisch Name:
FOLATES
Synonyma:
FOLATES
CBNumber:
CB71426790
Summenformel:
Molgewicht:
0
MOL-Datei:
Mol file

FOLATES Eigenschaften

Sicherheit

FOLATES Chemische Eigenschaften,Einsatz,Produktion Methoden

Allgemeine Beschreibung

Methotrexate is theclassic antimetabolite of folic acid structurally derived by Nmethylationof the para-aminobenzoic acid residue (PABA)and replacement of a pteridine hydroxyl by the bioisostericamino group. The conversion of —MOH to —MNH2 increasesthe basicity of N-3 and yields greater enzyme affinity. Thisdrug competitively inhibits the binding of the substrate folicacid to the enzyme DHFR, resulting in reductions in the synthesisof nucleic acid bases, perhaps most importantly, theconversion of uridylate to thymidylate as catalyzed bythymidylate synthetase.In addition, purine synthesis is inhibitedbecause the N-10-formyl tetrahydrofolic acid is aformyl donor involved in purine synthesis.
Recall that in Scheme 10.16, THFs are cofactors in at leasttwo key steps in the normal biosynthesis of purines.Methotrexate is a broad-spectrum antineoplastic agentcommonly used in the treatment of acute lymphoblastic andmyeloblastic leukemia and other lymphomas and sarcomas.The major side effects seen are bone marrow suppression,pulmonary fibrosis, and GI ulceration. Leucovorin is oftengiven 6 to 24 hours after methotrexate to prevent the longtermeffects on normal cells by preventing the inhibition ofDNA synthesis. Related to this is Pemetrexed, but its scopeis greater in that it not only inhibits DHFR but also TS andglycinamide ribonucleotide formyltransferase (GARFT),which is involved in purine biosynthesis.The material is taken into tumor cells by the reduced folatecarriersystems and subsequently converted to the polyglutamate,which is retained in the cell.

FOLATES Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


FOLATES Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 0)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate

  • FOLATES
Copyright 2019 ? ChemicalBook. All rights reserved
侯马市| 罗江县| 共和县| 郎溪县| 卓资县| 潞城市| 全州县| 尼勒克县| 景谷| 赤城县| 宜阳县| 新余市| 蒲城县| 广西| 尼勒克县| 天长市| 丹寨县| 岐山县| 池州市| 和硕县| 凤凰县| 新龙县| 偏关县| 泰安市| 丰宁| 天气| 洛川县| 黑水县| 井陉县| 合川市| 牡丹江市| 涿鹿县| 玛沁县| 绥德县| 沙坪坝区| 成都市| 松桃| 潮州市| 宁都县| 无棣县| 北辰区|