HYPERTENSION Chemische Eigenschaften,Einsatz,Produktion Methoden
Biologische Funktion
The calcium channel–blocking drugs are effective antihypertensive
agents and enjoy widespread use as single
medication or in combination. Their effectiveness is related
to a decrease in peripheral resistance accompanied
by increases in cardiac index. The magnitude of their effects
is determined partly by pretreatment blood pressure
levels; maximum blood pressure lowering generally
is seen 3 to 4 weeks after the start of treatment.
These drugs possess some distinct advantages relative
to other vasodilators, including the following:
1. Their relaxant effect on large arteries results in
greater compliance, which is beneficial in older
persons.
2. Tolerance associated with renal retention of fluid
does not occur; an initial natriuretic effect is often
observed, especially with the nifedipine group of
blockers.
3. They do not have significant effects on the release
of renin or cause long-term changes in lipid
or glucose metabolism.
4. Postural hypotension, first-dose effect, and rebound
phenomenon are not commonly seen.
Their antihypertensive efficacy is comparable to that
of β-adrenergic blockers and angiotensin-converting
enzyme (ACE) inhibitors.The choice of a calcium channel
blocker, especially for combination therapy, is
largely influenced by the effect of the drug on cardiac
pacemakers and contractility and coexisting diseases,
such as angina, asthma, and peripheral vascular disease.
HYPERTENSION Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
