2-hydroxypentanedioic acid

40951-21-1

CAS-Nr.: 40951-21-1

Englisch Name:: 2-hydroxypentanedioic acid

Synonyma:: 2-HG (sodium salt);Disodium 2-hydroxyglutarate;Disodium 2-hydroxypentanedioate;α-Hydroxyglutaric acid (sodium);α-Hydroxyglutaric acid (disodium);DL-ALPHA-HYDROXYGLUTARIC ACID DISODI;2-Hydroxyglutaric Acid (sodium salt);α-Hydroxyglutaric Acid (sodium salt);2-Hydroxyglutaric Acid Disodium Salt;2-Hydroxypentanedioic Acid SodiuM Salt

CBNumber:: CB71456168

Summenformel:: C5H9NaO5

Molgewicht:: 172.11

MOL-Datei:: 40951-21-1.mol

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Eigenschaften Sicherheit Verwendungswort Produktionsfirma 65

2-hydroxypentanedioic acid Eigenschaften

Schmelzpunkt:: >290C (dec.)

storage temp.: 2-8°C 2-8°C

L?slichkeit: Methanol (Slightly), Water (Slightly)

Aggregatzustand: Solid

Farbe: White to Off-White

Wasserl?slichkeit: Soluble to 100 mM in water

InChI: 1S/C5H8O5.2Na/c6-3(5(9)10)1-2-4(7)8;;/h3,6H,1-2H2,(H,7,8)(H,9,10);;/q;2*+1/p-2

InChIKey: DZHFTEDSQFPDPP-UHFFFAOYSA-L

SMILES: [Na+].[Na+].OC(CCC([O-])=O)C([O-])=O

Sicherheit

WGK Germany	3
Speicherklasse	11 - Combustible Solids

2-hydroxypentanedioic acid Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

α-Hydroxyglutaric acid (2-HG) is an α-hydroxy acid. It is metabolized to 2-oxoglutarate by D- and L-2-hydroxyglutarate dehydrogenases, and mutations in these enzymes lead to 2-hydroxyglutaric aciduria, a neurometabolic disorder characterized by increased levels of L-2-hydroxyglutaric acid . 2-HG can also be metabolized from isocitrate by mutated forms of isocitrate dehydrogenase 1 (IDH1) and IDH2. 2-HG is structurally similar to α-ketoglutarate, the product of wild-type isocitrate dehydrogenases, and competitively inhibits α-ketoglutarate-dependent dioxygenases, including histone lysine demethylases and DNA hydroxylases.

Chemische Eigenschaften

White to Off-White Solid

Verwenden

2-Hydroxyglutaric acid is a potential inhibitor of glutamate carboxypeptidase.

2-hydroxypentanedioic acid Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

2-hydroxypentanedioic acid Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 65)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19936	58
TargetMol Chemicals Inc.	+1-781-999-5354; +17819995354	marketing@targetmol.com	United States	32466	58
DAYANG CHEM (HANGZHOU) CO.,LTD	+86-88938639 +86-17705817739	info@dycnchem.com	China	53803	58
J & K SCIENTIFIC LTD.	18210857532; 18210857532	jkinfo@jkchemical.com	China	96815	76
Chemsky（shanghai）International Co.,Ltd.	021-50135380	shchemsky@sina.com	China	32321	50
Hangzhou Sage Chemical Co., Ltd.	+86057186818502 13588463833	info@sagechem.com	China	10266	58
Shanghai Raise Chemical Technology Co.,Ltd	15026594951	rs@raise-chem.com	China	4710	55
AdooQ BioScience, LLC	+1 (866) 930-6790	info@adooq.com	United States	2782	58
Bide Pharmatech Ltd.	400-400-164-7117 18317119277	product02@bidepharm.com	China	40000	60
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51395	80

DL-ALPHA-HYDROXYGLUTARIC ACID DISODI
(RS)-2-Hydroxypentanedioic acid disodium salt
Disodium 2-hydroxyglutarate
Pentanedioic acid, 2-hydroxy-, disodiuM salt
2-Hydroxypentanedioic Acid SodiuM Salt
DL-α-Hydroxyglutaric acid disodiuM salt
2-Hydroxyglutaric Acid Disodium Salt
2-Hydroxyglutaric Acid DisodiuM Salt, contains up to 10% Methanol
2-HG (sodium salt)
α-Hydroxyglutaric Acid (sodium salt)
2-Hydroxyglutaric Acid (sodium salt)
DL-alpha-Hydroxyglutaric acid disodium salt
DL-α-Hydroxyglutaric?acid?disodium?salt
Disodium 2-hydroxypentanedioate
α-Hydroxyglutaric acid (sodium)
α-Hydroxyglutaric acid (disodium)
D,L-2-Hydroxyglutaric acid disodium salt
DL α Hydroxyglutaric acid disodium salt,DLαHydroxyglutaric acid disodium salt
(RS)-2-Hydroxyglutaric acid disodium salt
DL-α-Hydroxyglutaric acid disodium salt
40951-21-1
Other APIs
Aliphatics
Inhibitors

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