2-[3,5-bis(trifluoromethyl)phenyl]-N,2-dimethyl-N-[4-(2-methylphenyl)-6-(4-methylpiperazin-1-yl)pyridin-3-yl]propanamide
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- CAS-Nr.
- 290297-26-6
- Englisch Name:
- 2-[3,5-bis(trifluoromethyl)phenyl]-N,2-dimethyl-N-[4-(2-methylphenyl)-6-(4-methylpiperazin-1-yl)pyridin-3-yl]propanamide
- Synonyma:
- Netupitant;NETUPITANT (RO 67-31898);Netupitan;CID6451149;CID-6451149;CID 6451149;Ro 67-31898;Nataipitide;Ro 67-31898/000;Netupitant(CID-6451149)
- CBNumber:
- CB71483126
- Summenformel:
- C30H32F6N4O
- Molgewicht:
- 578.59
- MOL-Datei:
- 290297-26-6.mol
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2-[3,5-bis(trifluoromethyl)phenyl]-N,2-dimethyl-N-[4-(2-methylphenyl)-6-(4-methylpiperazin-1-yl)pyridin-3-yl]propanamide Eigenschaften
- Schmelzpunkt:
- 156.2-160.0 °C
- Siedepunkt:
- 597.4±50.0 °C(Predicted)
- Dichte
- 1.255
- storage temp.
- 2-8°C
- L?slichkeit
- Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
- pka
- 7.89±0.38(Predicted)
- Aggregatzustand
- Solid
- Farbe
- White to Off-White
- InChIKey
- WAXQNWCZJDTGBU-UHFFFAOYSA-N
- SMILES
- C(N(C)C1=C(C2C=CC=CC=2C)C=C(N2CCN(C)CC2)N=C1)(=O)C(C1C=C(C(F)(F)F)C=C(C(F)(F)F)C=1)(C)C
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| WGK Germany |
WGK 3 |
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| Speicherklasse |
11 - Combustible Solids |
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| Hazard Classifications |
Eye Irrit. 2
Skin Irrit. 2 |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
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P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
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P264, P280, P305+P351+P338,P337+P313P |
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| Sicherheit |
| P302+P352 |
BEI BERüHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckm??ig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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2-[3,5-bis(trifluoromethyl)phenyl]-N,2-dimethyl-N-[4-(2-methylphenyl)-6-(4-methylpiperazin-1-yl)pyridin-3-yl]propanamide Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Netupitant, originally developed by Helsinn Healthcare and
later licensed to Eisai, Inc., was approved in the USA in October
2014 for the treatment of chemotherapy-induced nausea and emesis.
Akynzeo ® is a fixed-dose combination of the new drug
netupitant and the previously-approved 5-HT3 antagonist palonosetron.
While palonosetron obtained approval previously for treating
nausea and emesis occurring within the first 24 hours (acute
phase) after chemotherapy, netupitant provides a synergistic
effect with palonosetron, assisting in prevention of nausea
and emesis in later stages following chemotherapy (25–120 h after
chemotherapy treatment). Several clinical trials showed that
this combination of netupitant and palonosetron (Akynzeo ), in
comparison to treatment with palonosetron treatment alone, led
to an improved percentage of patients in all phases who did not
experience any nausea and emesis after undergoing chemotherapy. Netupitant itself joins the class of selective Neurokinin-
1 (NK1) receptor antagonists which, in addition to their use for treating chemotherapy-induced nausea and emesis,
also play an important role as therapies for depression and
anxiety.
Verwenden
Antiemetic.
Definition
ChEBI: A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoic acid with the secondary amino group of N-methyl-4-(2-methylphenyl)-6-(4-methylpiperazin-1-yl)pyridin
3-amine; an antiemetic used in combination with palonosetron hydrochloride (under the trade name Akynzeo) to treat nausea and vomiting in patients undergoing cancer chemotherapy.
2-[3,5-bis(trifluoromethyl)phenyl]-N,2-dimethyl-N-[4-(2-methylphenyl)-6-(4-methylpiperazin-1-yl)pyridin-3-yl]propanamide Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
2-[3,5-bis(trifluoromethyl)phenyl]-N,2-dimethyl-N-[4-(2-methylphenyl)-6-(4-methylpiperazin-1-yl)pyridin-3-yl]propanamide Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 242)Lieferanten
290297-26-6()Verwandte Suche:
- 2-[3,5-Bis(trifluoromethyl)phenyl]-N-[6-(4-methylpiperazin-1-yl)-4-(o-tolyl)pyridin-3-yl]-N-methylisobutyramide
- 2-[3,5-bis(trifluoromethyl)phenyl]-N,2-dimethyl-N-[4-(2-methylphenyl)-6-(4-methylpiperazin-1-yl)pyridin-3-yl]propanamide
- Ro 67-31898/000
- 2-(3,5-bis(trifluoroMethyl)phenyl)-N,2-
diMethyl-N-(6-(4-Methylpiperazin-1-yl)-4-
o-tolylpyridin-3-yl)propanaMide
- BenzeneacetaMide, N,a,a-triMethyl-N-[4-(2-Methylphenyl)-6-(4-Methyl-1-piperazinyl)-3-pyridinyl]-3,5-bis(trifluoroMethyl)-
- 2-[3,5-bis(trifluoromethyl)phenyl]-N,2-dimethyl-N-[4-(2-methylphenyl)-6-(4-methylpiperazin-1-yl)pyridin-3-
- Ro 67-31898
- Netupitan
- CID 6451149
- CID6451149
- CID-6451149
- Netupitant(CID-6451149)
- 2-[3,5-Bis(trifluoromethyl)phenyl]-N,2-dimethyl-N-[4-(2-methylphenyl)-6-(4-methylpiperazin-1-y
- Benzeneacetamide, N,α,α-trimethyl-N-[4-(2-methylphenyl)-6-(4-methyl-1-piperazinyl)-3-pyridinyl]-3,5-bis(trifluoromethyl)-
- 2-[3,5-bis(trifluoromethyl)phenyl]-N,2-dimethyl-N-[4-(2-meth...
- NetupitantQ: What is
Netupitant Q: What is the CAS Number of
Netupitant Q: What is the storage condition of
Netupitant Q: What are the applications of
Netupitant
- 2-dimethyl-N-[4-(2-methylphenyl)-6-(4-methylpiperazin-1-yl)pyridin-3-yl]propanamide
- 5-bis(trifluoromethyl)phenyl]-N
- NETUPITANT (RO 67-31898)
- Netupitant
- Nataipitide
- 290297-26-6
- 290297-36-6
- C30H32F6N4O
