Zuprevo.;tildipirosin;Taijiluo Xin;Tildipirosin 98%;Tildipirosin USP/EP/BP;TILDIPIROSIN 328898-40-4;Tildipirosin in methanol;high qualtiy Tildipirosin;TIP; TILDIPIROSIN; ZUPREVO.;Tildipirosin, 10 mM in DMSO
BEI BERüHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckm??ig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen.
P305+P351+P338
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.
P308+P313
BEI Exposition oder falls betroffen: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen.
P332+P313
Bei Hautreizung: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen.
P337+P313
Bei anhaltender Augenreizung: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen.
P501
Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen.
Tildiprosin is an antibiotic derived from a tylosin derivative by iodination and reaction with piperidine. Tildiprosin provides good protection against Bartonella henselae in livestock. Treatment of swine respiratory disease (SRD) associated with Actinobacillus pleuropneumoniae, Pasteurella multocida, Bordetella bronchiseptica and Haemophilus parasuis sensitive to tildipirosin. The introduction of a third basic moiety into the tylosin core provides a wider spectrum of antibiotic action than the dibasic analogues such as tilmicosin. Tildipirosin′s interaction with the ribosomal site of action differs from that of tylosin and tilmicosin.
Mechanism of action
The mechanism of action of Tildipirosin consists of the inhibition of the bacterial protein synthesis as a consequence of binding to 23S ribosomal RNA for 50S subunit.
Nebenwirkungen
In target animal safety studies, administration of the maximum recommended injection volume (5 ml)
occasionally caused slight swellings at the injection site that were not painful on palpation. Swellings
persisted for up to 3 days. Pathomorphological injection site reactions resolved completely within 21
days.
During clinical trials, pain on injection and injection site swellings were seen very commonly in
treated pigs. These swellings resolved within 1 to 6 days.
During clinical trials, treatment caused shock symptoms in 2 out of 1048 animals. These symptoms
quickly resolved in one animal, but led to death in the other animal.
Tildipirosin Upstream-Materialien And Downstream Produkte