Tiamulin
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- CAS-Nr.
- 55297-95-5
- Englisch Name:
- Tiamulin
- Synonyma:
- TIAMILIN;tiamulina;TiaMulin fuMerate API;(3aS,4R,5S,6S,8R,9R,9aR,10R)-Decahydro-8-[[2-(diethylamino)ethyl]thio]acetyloxy-5-hydroxy-4,6,9,10-tetramethyl-6-vinyl-3a,9-propano-3aH-cyclopentacycloocten-1-one;C12065;sq14055;tiavetp;iamulin;TIAMULIN;Tiamutin
- CBNumber:
- CB7171536
- Summenformel:
- C28H47NO4S
- Molgewicht:
- 493.74
- MOL-Datei:
- 55297-95-5.mol
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Tiamulin Eigenschaften
- Schmelzpunkt:
- 147.5°C
- Siedepunkt:
- 563.0±50.0 °C(Predicted)
- Dichte
- 1.0160 (rough estimate)
- Brechungsindex
- 1.6550 (estimate)
- storage temp.
- -20°C Freezer
- L?slichkeit
- Chloroform (Slightly), Ethanol (Slightly), Methanol (Slightly)
- pka
- 14.65±0.70(Predicted)
- Aggregatzustand
- Oil
- Farbe
- Colourless
- Major Application
- forensics and toxicology
pharmaceutical (small molecule)
- InChIKey
- UURAUHCOJAIIRQ-QGLSALSOSA-N
- SMILES
- C(O[C@@H]1C[C@](C=C)(C)[C@@H](O)[C@H](C)[C@@]23CC[C@@H](C)[C@]1(C)[C@]2([H])C(=O)CC3)(=O)CSCCN(CC)CC
- CAS Datenbank
- 55297-95-5(CAS DataBase Reference)
- EPA chemische Informationen
- Tiamulin (55297-95-5)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| WGK Germany |
2 |
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| RTECS-Nr. |
AG9552000 |
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| HS Code |
2941906000 |
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| Speicherklasse |
10 - Combustible liquids |
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| Hazard Classifications |
Aquatic Chronic 4 |
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| Giftige Stoffe Daten |
55297-95-5(Hazardous Substances Data) |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H413 |
Kann für Wasserorganismen sch?dlich sein, mit langfristiger Wirkung. |
Langfristig (chronisch) gew?ssergef?hrdend |
Kategorie 4 |
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| Sicherheit |
| P273 |
Freisetzung in die Umwelt vermeiden. |
| P501 |
Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen. |
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Tiamulin Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
Tiamulin is a semi–synthetic analogue of pleuromutilin in which the hydroxyacetyl side chain is replaced with a larger diethylaminoethylthioacetyl moiety, providing greater hydrophobicity and an ionisable group for salt formation and greater water solubility. Tiamulin is a potent and highly selective antibiotic active against a range of Gram positive bacteria, with no cross resistance to existing antibiotic classes due to its unique mode of action. Like pleuromutilin, it inhibits protein synthesis by binding to domain V of 23S rRNA.
Definition
ChEBI: A carbotricyclic compound that is pleuromutilin in which the hydroxyacetate group is replaced by a 2-{[2-(diethylamino)ethyl]sulfanyl}acetate group. An antibacterial drug, tiamulin is used in veterinary medicine (generally as its hydrogen fumarate salt) fo
the treatment of swine dysentery caused by Serpulina hyodysenteriae.
Sicherheitsprofil
Poison by
intramuscular and intravenous routes.
Moderately toxic by ingestion and
subcutaneous routes. When heated to
decomposition it emits toxic fumes of SOx
and NOx. See also MERCAPTANS.
Synthese
Tiamulin was synthesized by Sandoz Co. in 1973, starting from pleuromutilin produced by Pleurotus mutilus.
Tiamulin Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Tiamulin Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 241)Lieferanten
55297-95-5()Verwandte Suche:
- [[2-(Diethylamino)ethyl]thio]acetic acid [(3aS,10R,9aβ)-6α-ethenyldecahydro-5α-hydroxy-4β,6,9,10-tetramethyl-1-oxo-3aα,9α-propano-3aH-cyclopentacycloocten]-8β-yl ester
- [[2-(Diethylamino)ethyl]thio]acetic acid [(3aS,9aβ,10R)-6α-ethenyldecahydro-5α-hydroxy-4β,6,9,10-tetramethyl-1-oxo-3aα,9α-propano-3aH-cyclopentacycloocten]-8β-yl ester
- [2-(Diethylamino)ethylthio]acetic acid [(3aS,9aβ,10R)-6α-ethenyldecahydro-5α-hydroxy-4β,6,9,10-tetramethyl-1-oxo-3aα,9α-propano-3aH-cyclopentacycloocten]-8β-yl ester
- C12065
- Tiamulin (100 mg)
- ,10-tetramethyl-1-oxo-3a,9-propano-3ah-cyclopentacycloocten-8-ylester,(3as-(
- 14-deoxy-14-((2-diethylaminoethyl-thio)-acetoxy)mutiline
- 4-beta,5-alpha,6-alpha,8-beta,9-beta,10s*))-3a-alph
- aceticacid,((2-(diethylamino)ethyl)thio)-,6-ethenyldecahydro-5-hydroxy-4,6,9
- sq14055
- thiamutilin
- tiavetp
- TIAMULIN
- (1S,2R,3S,4S,6R,7S,14R)-6-[(2-DIETHYLAMINOETHYLTHIO)ACETOXY]-3-HYDROXY-2,4,7,14-TETRAMETHYL-4-VINYLTRICYCLO[5,4,3,01.8]TETRADECAN-9-ONE
- 5-hydroxy-4,6,9,10-tetramethyl-1-oxo-6-vinyldecahydro-3a,9-propanocyclopenta[8]annulen-8-yl hydroxyacetate
- Tiamutin
- Acetic acid, 2-(diethylamino)ethylthio-, (3aS,4R,5S,6S,8R,9R,9aR,10R)-6-ethenyldecahydro-5-hydroxy-4,6,9,10-tetramethyl-1-oxo-3a,9-propano-3aH-cyclopentacycloocten-8-yl ester
- Tiamulin Solution, 1000ppm
- Tiamulin Solution, 100ppm
- Thiamuline
- Tiamulin for peak identification CRS
- Acetic acid, 2-[[2-(diethylamino)ethyl]thio]-, (3aS,4R,5S,6S,8R,9R,9aR,10R)-6-ethenyldecahydro-5-hydroxy-4,6,9,10-tetramethyl-1-oxo-3a,9-propano-3aH-cyclopentacycloocten-8-yl ester
- iamulin
- Tiamulin hyclate
- TiamulinQ: What is
Tiamulin Q: What is the CAS Number of
Tiamulin Q: What is the storage condition of
Tiamulin
- TIANFU-CHEM - Tiamulin
- Tiamulin (1667355)
- TIAMILIN
- (3aS,4R,5S,6S,8R,9R,9aR,10R)-Decahydro-8-[[2-(diethylamino)ethyl]thio]acetyloxy-5-hydroxy-4,6,9,10-tetramethyl-6-vinyl-3a,9-propano-3aH-cyclopentacycloocten-1-one
- TiaMulin fuMerate API
- Tiamulin in methanol
- Tiamulin fumarate in Methanol
- C17575790 Tiamulin
- Tiamulin (Standard)
- tiamulina
- 55297-95-5
- 55297-96-5
- 55297-98-6
- C28H47NO4S
