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Leuprorelin acetate

Leuprorelin acetate Struktur
74381-53-6
CAS-Nr.
74381-53-6
Englisch Name:
Leuprorelin acetate
Synonyma:
LEUPROLIDE;Leuprolide acetate;lupron;Leuprolide acetate (Leuprorelin acetate);6-D-Leucine-9-(N-ethyl-L-prolinamide)-10-deglycinamideluteinizing Hormone-Releasing Factor Acetate(Pig);tap-144;Prostap;Procrin;TPA-144;DC-2-269
CBNumber:
CB7174300
Summenformel:
C61H88N16O14
Molgewicht:
1269.47
MOL-Datei:
74381-53-6.mol

Leuprorelin acetate Eigenschaften

Schmelzpunkt:
150-155°C
storage temp. 
-20°C
L?slichkeit
DMSO (Slightly), Methanol (Slightly)
Aggregatzustand
Solid
Farbe
White to Off-White
Merck 
14,5457
InChIKey
RGLRXNKKBLIBQS-XNHQSDQCSA-N
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
S-S?tze: 22-24/25
WGK Germany  2
RTECS-Nr. OH6390000
HS Code  29371900
Speicherklasse 11 - Combustible Solids
Bildanzeige (GHS) Exclamation Mark (GHS07)
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung P264, P280, P302+P352, P321,P332+P313, P362
Sicherheit
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P302+P352 BEI BERüHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckm??ig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen.
P332+P313 Bei Hautreizung: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen.

Leuprorelin acetate Chemische Eigenschaften,Einsatz,Produktion Methoden

S-S?tze Betriebsanweisung:

S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.

Beschreibung

Leuprolide acetate is a potent analog of LH-RH useful in achieving a medical castration in the treatment of advanced prostate cancer. It has also been investigated for the treatment of advanced breast cancer.

Chemische Eigenschaften

Fluffy Solid

Verwenden

Synthetic nonapeptide agonist analog of LH-RH. Antineoplastic (hormonal).

Definition

ChEBI: An acetate salt obtained by combining the nonapeptide leuprolide with acetic acid. A long lasting GnRH analog, LH-Rh agonist. It is a synthetic nonapeptide analogue of gonadotropin-releasing hormone, and is used as a subcutaneous hydrogel implant for the t eatment of prostate cancer and for the suppression of gonadal sex hormone production in children with central precocious puberty.

Pharmakologie

Leuprolide, 5-oxo-L-prolyl-L-histadyl-L-tryptophyl-L-seryl-L-tyrosyl-D-leucil-L-leucil-L-arginyl-N-ethyl-L-prolinamide (30.5.9), is made synthetically.
pyroGlu-His-Trp-Ser-Tyr-D-Leu-Leu-Arg-Pro-NHEt
The nonapeptide leuprolide is a synthetic analog of the decapeptide, gonadotropin releasing hormone, and it exceeds the activity of the natural hormone and significantly elevates the level of testosterone and dihydrotestosterone in men, and estrogen in women. It also inhibits follicle-stimulating hormone and leutenizing hormone.
Leuprolide is used for prostate cancer, when orchiectomy or estrogen therapy is counterproductive to the patient. A synonym of this drug is lupron.

Arzneimittelwechselwirkung

Leuprorelin acetate can not take with mang drugs, such as chasteberry, cisapride, dronedarone, pimozide, or thioridazine. This medicine may also interact with the following medications: herbal or dietary supplements, like black cohosh or DHEA; female hormones, like estrogens or progestins and birth control pills, patches, rings, or injections; male hormones, like testosterone; other medicines that prolong the QT interval (abnormal heart rhythm).

Leuprorelin acetate Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Leuprorelin acetate Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 421)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Shanghai Yunao International Trade Co., Ltd
+8617621705551
asdf@shanghaihg.cn China 264 58
qingdao future trading Co., Ltd
+86-13335044410
cui56813@163.com China 110 58
Shandong Huisheng Import & Export Co., Ltd.
+86-13176845580
da@zhongda-biotech.com China 232 58
Anhui Zhongda Biotechnology Co., Ltd
+8619956560829
justine@zhongda-biotech.com China 286 58
Anhui Zhongda Biotechnology Co., Ltd
+8615689548120
linda@zhongda-biotech.com China 193 58
Anhui Ruihan Technology Co., Ltd
+8617756083858
daisy@anhuiruihan.com China 973 58
Henan Fengda Chemical Co., Ltd
+86-371-86557731 +86-13613820652
info@fdachem.com China 20121 58
Hangzhou Hyper Chemicals Limited
+86-0086-57187702781 +8613675893055
info@hyper-chem.com China 310 58
Shaanxi Xianhe Biotech Co., Ltd
+86-17709210191; +8617709210191
Jerry@xhobio.com China 906 58
Rongchuang International
+8613175533356
kevin@rongchuangintl.com China 272 58

74381-53-6()Verwandte Suche:


  • leutenizinghormone-releasingfactor(pig),6-d-leucine-9-(n-ethyl-l-prolinamid
  • tap-144
  • Abbott 43818
  • Procren Depot
  • Procrin
  • Prostap
  • M.W. 1209.40 C59H84N16O12
  • DC-2-269
  • TPA-144
  • [Des-Gly10,Dleu6, ProNHEt9] LH-RH, AcetateLeuprolide, Acetate
  • Leuprorelin acetate
  • Leuprorelin Acetate (See L1881)
  • (Des-Gly10,D-Leu6,Pro-NHEt9)-LHRH Leuprorelin, Leuprolide
  • Leuprolide Acetate (200 mg) (INTERNATIONAL COLD CHAIN SHIPMENT REQUIRED)
  • 6-D-Leucine-9-(N-ethyl-L-prolinaMide)-
  • Leuprorelin, Leuprolide
  • Leuprorelin, des-Gly10-[D-Leu6]-LH-RH ethylamide
  • Leuprorelin acetate, Ph. Eur.
  • Monoacetate (salt)
  • tap-144-sr
  • DES-GLY10,[P-LEU6]-LH-RH ETHYLAMIDE
  • [DES-GLY10, D-LEU6, PRO-NHET9]-LH-RH (HUMAN)
  • (DES-GLY10,D-LEU6,PRO-NHET9)-LUTEINIZING HORMONE-RELEASING FACTOR
  • (DES-GLY10,D-LEU6,PRO-NHET9)-LUTEINIZING HORMONE-RELEASING HORMONE
  • [DES-GLY10, D-LEU6, PRO-NHET9]-LUTEINIZING HORMONE-RELEASING HORMONE HUMAN
  • [DES-GLY10, DLEU6, PRO9]-LH-RH, ETHYL AMIDE
  • [DES-GLY10, DLEU6, PRO9]-LUTEINIZING HORMONE-RELEASING HORMONE, ETHYL AMIDE
  • [DES-GLY10, DLEU 6, PRONHET9]
  • (DES-GLY10,D-LEU6,PRO-NHET9)-GONADOTROPIN-RELEASING HORMONE
  • (DES-GLY10,D-LEU6,PRO-NHET9)-LHRH
  • GLP-HIS-TRP-SER-TYR-D-LEU-LEU-ARG-PRO-NHET
  • LH-RH LEUPROLIDE
  • LEUPROLIDE (HUMAN)
  • 5-OXOPRO-HIS-TRP-SER-TYR-D-LEU-LEU-ARG-PRO-NHC2H5
  • PYR-HIS-TRP-SER-TYR-D-LEU-LEU-ARG-PRO-NHET
  • PYROGLU-HIS-TRP-SER-TYR-D-LEU-LEU-ARG-PRO NHCH2CH3
  • PGLU-HIS-TRP-SER-TYR-P-LEU-LEU-ARG-PRO-NHET
  • PGLU-HIS-TRP-SER-TYR-D-LEU-LEU-ARG-PRO-NHET
  • des-gly10-[d-leu6]-lh-rh ethylamide
  • leuprolide acetate salt
  • LEUPROPELINACETATE
  • Leuprorelin acetate, 98%, an agonist at pituitary GnRH receptors
  • Leuprorelin Acetate RS
  • Leuproprelin acetate
  • (S)-1-((3S,6S,9S,12S,15R,18S,21S)-3-((1H-imidazol-4-yl)methyl)-6-((1H-indol-3-yl)methyl)-21-(3-guanidinopropyl)-12-(4-hydroxybenzyl)-9-(hydroxymethyl)-15,18-diisobutyl-1,4,7,10,13,16,19-heptaoxo-1-((S)-5-oxopyrrolidin-2-yl)-2,5,8,11,14,17,20-heptaazadocosan-22-oyl)-N-ethylpyrrolidine-2-carboxamideacetate
  • Leuprorelin?Acetate impurity
  • Leuprorelin acetate USP/EP/BP
  • Leuprorelin AcetateQ: What is Leuprorelin Acetate Q: What is the CAS Number of Leuprorelin Acetate Q: What is the storage condition of Leuprorelin Acetate Q: What are the applications of Leuprorelin Acetate
  • Leuprorelin D10 Acetate
  • Leuprolide Acetate(acetate)
  • Leuprolide Acetate (INTERNATIONAL COLD CHAIN SHIPMENT REQUIRED) (1358503)
  • lupron
  • 6-D-Leucine-9-(N-ethyl-L-prolinamide)-10-deglycinamideluteinizing Hormone-Releasing Factor Acetate(Pig)
  • Leuprolide acetate (Leuprorelin acetate)
  • (Des-Gly10,D-Leu6,Pro-NHEt9)-LHRH acetate salt
  • Leuprorelin acetate salt
  • 2H10]-Leuprorelin acetate salt
  • (Des-Gly??,D-Leu?,Pro-NHEt?)-LHRH acetate salt
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