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9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-dien-3,20-dion

9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione  Struktur
981-34-0
CAS-Nr.
981-34-0
Bezeichnung:
9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-dien-3,20-dion
Englisch Name:
9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione
Synonyma:
DB11;16-BETA METHYL EPOXIDE;9beta,11beta-epoxy-17alpha,21-dihydroxy-16beta-methylene-pregna-1,4-diene-3,20-dione;(9β,11β,16β)-;Einecs 213-563-4;16β Methyl Epoxide;9beta,11beta-Epoxy-1;11beta-Epoxy-17alpha;Betamethasone epoxide;16-beta Methyl Epoxid
CBNumber:
CB72129663
Summenformel:
C22H28O5
Molgewicht:
372.45
MOL-Datei:
981-34-0.mol

9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-dien-3,20-dion Eigenschaften

Schmelzpunkt:
210-220 ºC
Siedepunkt:
564.9±50.0 °C(Predicted)
Dichte
1.32±0.1 g/cm3(Predicted)
Dampfdruck
0-357.304Pa at 25℃
storage temp. 
Refrigerator
L?slichkeit
Chloroform (Slightly, Heated), Dioxane (Slightly, Heated), DMSO (Slightly, Heated)
Aggregatzustand
Solid
pka
12.56±0.70(Predicted)
Farbe
White to Light Beige
Major Application
pharmaceutical small molecule
InChIKey
GBDXNHBVYAMODG-OBDZOPJXNA-N
SMILES
C[C@]12C=CC(=O)C=C1CC[C@@]1([H])[C@]3([H])C[C@H](C)[C@](O)(C(=O)CO)[C@@]3(C)C[C@@H]3O[C@]213 |&1:1,10,12,15,17,23,26,28,r|

Sicherheit

9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-dien-3,20-dion Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione (Betamethasone EP Impurity E) is a metabolite of Mometasone Furoate (M490000) which is a tropical corticosteroid used as an anti-inflammatory. Low solubility in most solvent. 9,11β-epoxysteroid compounds can be prepared by 9-position fluorination to obtain dexamethasone. By modifying its 3-bit, 6-bit, 16-bit, and 21-bit, a series of drugs can be prepared.

Chemische Eigenschaften

Off-White Solid

synthetische

Add sodium sulfite and sodium hydroxide to water, stir to dissolve, and then add methanol. The raw material was added for hydrolysis reaction. After the reaction for 3h, glacial acetic acid was added to adjust the pH=6~8. The water was added to the solution and crystallize at 0 ℃. Finally, 9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione was obtained after purification.
9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione

9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-dien-3,20-dion Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-dien-3,20-dion Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 231)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Nanjing Shizhou Biotechnology Co., Ltd
+86-15850508050
sean.lv@synzest.com China 323 58
Nantong Guangyuan Chemicl Co,Ltd
+undefined17712220823
admin@guyunchem.com China 615 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21587 55
Nanjing ChemLin Chemical Industry Co., Ltd.
025-83697070
product@chemlin.com.cn CHINA 3009 60
career henan chemical co
+86-0371-86658258 +8613203830695
sales@coreychem.com China 29815 58
Xiamen AmoyChem Co., Ltd
+86-86-5926051114 +8615060885618
sales@amoychem.com China 6366 58
Standardpharm Co. Ltd.
86-714-3992388
overseasales1@yongstandards.com United States 14332 58
BOC Sciences
+1-631-485-4226
inquiry@bocsci.com United States 19936 58
Alchem Pharmtech,Inc.
8485655694
sales@alchempharmtech.com United States 63687 58
Hebei shuoxi biotechnology co. LTD
+8613081092107
CHINA 964 58

981-34-0(9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-dien-3,20-dion)Verwandte Suche:


  • (9β)-9,11β-Epoxy-16β-methyl-17,21-dihydroxypregna-1,4-diene-3,20-dione
  • 9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione
  • Einecs 213-563-4
  • Betamethasone 9,11-Epoxide
  • (9β,11β,16β)-
  • 9beta,11beta-Epoxy-1
  • DB11(16B-Methyl Epoide)
  • DB11(16β-Methyl Epoide)
  • (4aS,4bS,5aS,6aS,7R,8S,9aS,9bS)-7-Hydroxy-7-(2-hydroxyacetyl)-4a,6a,8-triMethyl-5a,6,6a,7,8,9,9a,9b,10,11-decahydrocyclopenta[1,2]phenanthro[4,4a-b]oxiren-2(4aH)-one
  • Betamethasone epoxide
  • (4aS,4bS,5aS,6aS,7R,9aS,9bS)-7-Hydroxy-7-(2-hydroxyacetyl)-4a,6a-Dimethyl-8-methylene-5a,6,6a,7,8,9,9a,9b,10,11-decahydrocyclopenta[1,2]phenanthro[4,4a-b]oxiren-2(4aH)-one
  • Pregna-1,4-diene-3,20-dione,9
  • 17α,21-dihydroxy-9β,11β-epoxy-16β-methylpregna-1,4-diene-3,20-dione
  • Beclomethasone EP Impurity R
  • Betamethasone Impurity 5(Betamethasone EP Impurity E)
  • Beclometasone Dipropionate?EP Impurity R
  • 16-beta Methyl Epoxid
  • 9,11beta-Epoxy-17,21-dihydroxy-16be
  • 9Beta,11beta-Epoxy-17alpha,21-dihydroxy-16beta-methylene-pregna-1,4-diene-3,20-dione[DB11]
  • Pregna-1,4-diene-3,20-dione, 9,11-epoxy-17,21-dihydroxy-16-methyl-, (9β,11β,16β)-
  • Beta,11beta-Epoxy-17alpha,21-dihydroxy-16beta-methylene-pregna-1,4-diene-3,20-dione
  • Beclomethasone Impurity 6
  • Beclomethasone propionate EP impurity R
  • Beclomethasone Impurity 15(Beclometasone Dipropionate EP Impurity R)
  • 9-beta,11-beta-epoxy-17-alpha,21-dihydroxy-16-beta-methylene...
  • DB11(16β-Methyl Epoxide)
  • 11beta-Epoxy-17alpha
  • 9,11β-Epoxy-17,21-dihydroxy-16β-methyl-9β-pregna-1,4-diene-3,20-dione
  • Beclomethasone dipropionate EP Impurity R
  • 9-β,11-β-epoxy-17-α,21-dihydroxy-16-beta-methylenepregna-1,4-diene-3,20-dione
  • Beclometasone Dipropionate Impurity R
  • Beclometasone Propionate EP Impurity R
  • Betamethasone Impurity E
  • Beclometasone Propionate EP Impurity R(Betamethasone EP Impurity E)
  • Beclomethasone Dipropionate EP Impurity R (Betamethasone 9,11-Epoxide)
  • Betamethasone 9,11-Epoxide (Beclomethasone Dipropionate EP Impurity R)
  • Betamethasone epoxy hydrolysate
  • 9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregnα-1,4-diene-3,20-dione
  • 9beta,11beta-Epoxy-17alpha,21-dihydroxy-16beta-met
  • 93.113-Epoxy-17a,21-dihydroxy-16p -methylenepregna-1.4-diene-3.20-dione(DB11)
  • (9β,11β,16β)-9,11-Epoxy-17,21-dihydroxy-16-methylpregna-1,4-diene-3,20-dione
  • Betamethasone epoxide hydrolase
  • Beclometasone Dipropionate EP Impurity R (Betamethasone 9,11-Epoxide)
  • Beclometasone Impurity R
  • 9,11beta-Epoxy-17,21-dihydroxy-16beta-methyl-9beta-pregna-1,4-diene-3,20-dione
  • Betamethasone Epoxide Hydrolyzate
  • Beclomethasone Propionate intermediate
  • DB Xl - 9beta,11beta-Epoxy-17alpha,21-dihydroxy-16beta-methylene-pregna-1,4-diene-3,20-dione
  • 16β Methyl Epoxide
  • 9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione
  • Betamethasone 9,11-Epoxide(DB11)
  • 9beta,11beta-Epoxy-17alpha
  • Beclometasone (Beclomethasone) Dipropionate EP Impurity R (Betamethasone 9,11-Epoxide)
  • 16-BETA METHYL EPOXIDE
  • 9beta,11beta-epoxy-17alpha,21-dihydroxy-16beta-methylene-pregna-1,4-diene-3,20-dione
  • DB11
  • 981-34-0
  • Intermediates & Fine Chemicals
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