SC-51322
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- CAS-Nr.
- 146032-79-3
- Englisch Name:
- SC-51322
- Synonyma:
- SC-51322;SC-51322, EP1 receptor antagonist;8-Chloro-dibenz[b,f][1,4]oxazepine-10(11H)-carboxylic Acid 2-[3-[(2-FuranylMethyl) thio]-1-oxopropyl]hydrazide;8-Chloro-2-[3-[(2-furanylmethyl)thio]-1-oxopropyl]-dibenz(Z)[b,f][1,4]oxazepine-10(11H)-carboxylicacidhydrazide;Dibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid, 8-chloro-, 2-[3-[(2-furanylmethyl)thio]-1-oxopropyl]hydrazide
- CBNumber:
- CB7235197
- Summenformel:
- C22H20ClN3O4S
- Molgewicht:
- 457.93
- MOL-Datei:
- Mol file
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SC-51322 Eigenschaften
- Schmelzpunkt:
- 112-114°C
- RTECS-Nr.
- HQ4002000
- storage temp.
- Store at +4°C
- L?slichkeit
- DMSO: ≥10mg/mL
- Aggregatzustand
- powder
- Farbe
- white to off-white
- InChI
- 1S/C22H20ClN3O4S/c23-16-7-8-20-18(12-16)26(13-15-4-1-2-6-19(15)30-20)22(28)25-24-21(27)9-11-31-14-17-5-3-10-29-17/h1-8,10,12H,9,11,13-14H2,(H,24,27)(H,25,28)
- InChIKey
- CQBVTZDISUKDSX-UHFFFAOYSA-N
- SMILES
- Clc1ccc2Oc3ccccc3CN(C(=O)NNC(=O)CCSCc4ccco4)c2c1
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Kennzeichnung gef?hrlicher |
T |
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| R-S?tze: |
25 |
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| S-S?tze: |
45 |
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| RIDADR |
UN 2811 6.1 / PGIII |
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| WGK Germany |
3 |
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| HazardClass |
6.1 |
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| Speicherklasse |
6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects |
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| Hazard Classifications |
Acute Tox. 3 Oral |
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| Bildanzeige (GHS) |
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| Alarmwort |
Achtung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H301 |
Giftig bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 3 |
Achtung |
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P264, P270, P301+P310, P321, P330,P405, P501 |
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| Sicherheit |
| P301+P310 |
BEI VERSCHLUCKEN: Sofort GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen. |
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SC-51322 Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
The prostaglandin E
2 (PGE
2) receptor (EP
1) is involved in triggering PGE
2-
mediated pain as well as neuronal survival and growth. SC-
51322 is a selective EP
1 antagonist that inhibits PGE
2 signaling in a guinea pig ileum muscle strip assay with a pA
2 value of 8.1 and demonstrates analgesic activity in a mouse writhing assay with an ED
50 value of 0.9 mg/kg. It is pharmacologically similar to SC-
51089, but does not release hydrazine, a known carcinogen to rats, as does SC-
51089. SC-
51322 potentiates the vasorelaxation of human pulmonary vein induced by PGE
2 with an EC
50 value of 7.75 μM.
Chemische Eigenschaften
Off-White Solid
Verwenden
A selective E-prostanoid receptor subtype 1 (EP1) receptor antagonist which shows antihypertensive effects.
SC-51322 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
SC-51322 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 44)Lieferanten
146032-79-3()Verwandte Suche:
- SC-51322
- 8-Chloro-2-[3-[(2-furanylmethyl)thio]-1-oxopropyl]-dibenz(Z)[b,f][1,4]oxazepine-10(11H)-carboxylicacidhydrazide
- 8-Chloro-dibenz[b,f][1,4]oxazepine-10(11H)-carboxylic Acid 2-[3-[(2-FuranylMethyl) thio]-1-oxopropyl]hydrazide
- Dibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid, 8-chloro-, 2-[3-[(2-furanylmethyl)thio]-1-oxopropyl]hydrazide
- SC-51322, EP1 receptor antagonist
- 146032-79-3
- Amines
- Heterocycles
- Inhibitors
- Intermediates & Fine Chemicals
- Pfizer compounds
- Pharmaceuticals
- Sulfur & Selenium Compounds
