2-[(3-CHLOROPHENYL)METHOXY]-6-(1-PIPERAZINYL)PYRAZINE HYDROCHLORIDE
|
|
|
- CAS-Nr.
- 479683-64-2
- Englisch Name:
- 2-[(3-CHLOROPHENYL)METHOXY]-6-(1-PIPERAZINYL)PYRAZINE HYDROCHLORIDE
- Synonyma:
- CS-687;CP809101;CP-809101;CP 809101;CP809101/CP-809101;CP 809101 hydrochlor;CP-809102 hydrochloride;CP 809101 HYDROCHLORIDE;Pyrazine, 2-[(3-chlorophenyl)methoxy]-6-(1-piperazinyl)-;6'-(3-Chlorobenzyloxy)-3,4,5,6-tetrahydro-2H-[1,2']bipyrazine
- CBNumber:
- CB72454336
- Summenformel:
- C15H17ClN4O
- Molgewicht:
- 304.77
- MOL-Datei:
- 479683-64-2.mol
|
2-[(3-CHLOROPHENYL)METHOXY]-6-(1-PIPERAZINYL)PYRAZINE HYDROCHLORIDE Eigenschaften
- Siedepunkt:
- 486.6±45.0 °C(Predicted)
- Dichte
- 1.265±0.06 g/cm3(Predicted)
- storage temp.
- Desiccate at RT
- L?slichkeit
- DMSO
- Aggregatzustand
- powder
- pka
- 8.24±0.10(Predicted)
- Farbe
- white to beige
- InChI
- 1S/C15H17ClN4O/c16-13-3-1-2-12(8-13)11-21-15-10-18-9-14(19-15)20-6-4-17-5-7-20/h1-3,8-10,17H,4-7,11H2
- InChIKey
- PCWGGOVOEWHPMG-UHFFFAOYSA-N
- SMILES
- Clc1cc(ccc1)COc2nc(cnc2)N3CCNCC3
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| WGK Germany |
WGK 3 |
|
|
| Speicherklasse |
11 - Combustible Solids |
|
|
| Hazard Classifications |
Acute Tox. 4 Oral |
|
|
| Bildanzeige (GHS) |
|
| Alarmwort |
Warnung
|
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
|
P264, P270, P301+P312, P330, P501 |
|
| Sicherheit |
|
2-[(3-CHLOROPHENYL)METHOXY]-6-(1-PIPERAZINYL)PYRAZINE HYDROCHLORIDE Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
CP 809101 is a potent and selective SR-2C and 5-HT2C agonist.
Biologische Aktivit?t
Potent and selective 5-HT 2C receptor agonist (pEC 50 values are 9.96, 7.19 and 6.81 for human 5-HT 2C , 5-HT 2B and 5-HT 2A receptors respectively). Displays antipsychotic activity; suppresses condition avoidance responding (CAR) and inhibits PCP and amphetamine-stimulated hyperactivity in rats following subcutaneous administration.
Biochem/physiol Actions
CP-809,101 is a potent and high-affinity 5-hydroxytryptamine receptor 2C (5-HT2C) full agonist with only weaker partial agonist activity toward 5-HT2A & 5-HT2B (cellular Ca2+ mobilization EC50 in nM/efficiency = 0.11/93% and 0.06/97% with human and rat 5-HT2C, respectively; 153/67%/human 5HT2A, 65.3/57%/human 5HT2B, 119/79%/rat 5HT2A) and much reduced or little affinity toward other receptors, ion channels and uptake sites tested. CP-809,101 exhibits antipsychotic efficacy in reducing conditioned avoidance response/CAR (ED50 = 4.8 mg/kg s.c.) and locomotor activity (ED50 in mg/kg via s.c. = 2/rats, 1/mice; no effect up to 10 mg/kg in 5-HT2C-knockout mice), while oral administration is reported to suppress spontaneous and nocturnal food intake as well as fasting-induced refeeding in rats (～8% and ～24% reduction of cumulative food intake and body weight in 4 days, respectively; 30 mg/kg/day p.o.).
2-[(3-CHLOROPHENYL)METHOXY]-6-(1-PIPERAZINYL)PYRAZINE HYDROCHLORIDE Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
2-[(3-CHLOROPHENYL)METHOXY]-6-(1-PIPERAZINYL)PYRAZINE HYDROCHLORIDE Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 58)Lieferanten
- 2-[(3-CHLOROPHENYL)METHOXY]-6-(1-PIPERAZINYL)PYRAZINE HYDROCHLORIDE
- CP 809101 HYDROCHLORIDE
- CP 809101
- CP809101
- CP-809101
- 6'-(3-Chlorobenzyloxy)-3,4,5,6-tetrahydro-2H-[1,2']bipyrazine
- CP809101/CP-809101
- CS-687
- Pyrazine, 2-[(3-chlorophenyl)methoxy]-6-(1-piperazinyl)-
- CP 809101 hydrochlor
- CP-809102 hydrochloride
- 479683-64-2
- C15H17N4OClHCl
- Potent and selective 5-HT2C receptor agonist
