Glycine, L-g-glutaMyl-S-(phenylMethyl)-L-cysteinyl-2-phenyl-,1,3-diethyl ester, (2R)-
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- CAS-Nr.
- 168682-53-9
- Englisch Name:
- Glycine, L-g-glutaMyl-S-(phenylMethyl)-L-cysteinyl-2-phenyl-,1,3-diethyl ester, (2R)-
- Synonyma:
- Ezatiostat;CS-1110;Terrapin 199;Ezatiostat, >96%;TER199(free base);Ezatiostat, >=98%;Ezatiostat (TER199);Ezatiostat salt free;Ezatiostat 168682-53-9;Ezatiostat, 10 mM in DMSO
- CBNumber:
- CB72563432
- Summenformel:
- C27H35N3O6S
- Molgewicht:
- 529.65
- MOL-Datei:
- 168682-53-9.mol
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Glycine, L-g-glutaMyl-S-(phenylMethyl)-L-cysteinyl-2-phenyl-,1,3-diethyl ester, (2R)- Eigenschaften
- Schmelzpunkt:
- >94°C (dec.)
- Siedepunkt:
- 749.7±60.0 °C(Predicted)
- Dichte
- 1.216±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
- L?slichkeit
- DMSO (Slightly), Methanol (Slightly)
- Aggregatzustand
- Solid
- pka
- 12+-.0.46(Predicted)
- Farbe
- White to Off-White
- InChIKey
- FXTMNDVNPLUYKX-OKIYALLLNA-N
- SMILES
- C(OCC)(=O)[C@@H](C1=CC=CC(CC)=C1)N(C(=O)CC[C@@H](C(O)=O)N)C(=O)[C@H](CSCC1=CC=CC=C1)N |&1:5,19,26,r|
Sicherheit
| WGK Germany |
WGK 3 |
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| Speicherklasse |
11 - Combustible Solids |
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Glycine, L-g-glutaMyl-S-(phenylMethyl)-L-cysteinyl-2-phenyl-,1,3-diethyl ester, (2R)- Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Ezatiostat is an inhibitor of glutathione S-transferase pi 1-1 (GSTP1-1; K
i = 0.4 μM). It is selective for GSTP1-1 over GSTα and GSTμ family GSTs (K
is = 20-75 μM). Ezatiostat also inhibits the protein-protein interaction between GSTP1-1 and JNK1.
In vivo, ezatiostat (75 mg/kg) increases the number of circulating white blood cells in
Gstp1 wild-type, but not
Gstp1-/-, mice.
Verwenden
Ezatiostat is a tripeptide analog of glutathione that can selectively inhibit GSTP1-1, the most prevalent Glutathione S-transferases (GST) isozyme in nonhepatic tissues, catalytic activity with minimal effect on the related GSTα and -μ families.
Glycine, L-g-glutaMyl-S-(phenylMethyl)-L-cysteinyl-2-phenyl-,1,3-diethyl ester, (2R)- Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Glycine, L-g-glutaMyl-S-(phenylMethyl)-L-cysteinyl-2-phenyl-,1,3-diethyl ester, (2R)- Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 115)Lieferanten
168682-53-9()Verwandte Suche:
- (S)-ETHYL 2-AMINO-5-((R)-3-(BENZYLTHIO)-1-((R)-2-ETHOXY-2-OXO-1-PHENYLETHYLAMINO)-1-OXOPROPAN-2-YLAMINO)-5-OXOPENTANOATE
- (2R)-L-gamma-Glutamyl-S-(phenylmethyl)-L-cysteinyl-2-phenylglycine 1,3-diethyl ester
- Glycine, L-g-glutaMyl-S-(phenylMethyl)-L-cysteinyl-2-phenyl-,1,3-diethyl ester, (2R)-
- Terrapin 199
- Ezatiostat, >=98%
- Ezatiostat, >96%
- CS-1110
- TER 199; TLK-199; TELINTRA
- Ezatiostat (TER199)
- Ezatiostat TFA (free base)
- TER199(free base)
- Glycine, L-γ-glutamyl-S-(phenylmethyl)-L-cysteinyl-2-phenyl-, 1,3-diethyl ester, (2R)-
- Ethyl N5-((R)-3-(benzylthio)-1-(((R)-2-ethoxy-2-oxo-1-phenylethyl)amino)-1-oxopropan-2-yl)-L-glutaminate
- Ezatiostat salt free
- Ezatiostat 168682-53-9
- Ezatiostat(TER199, TLK199)
- Ezatiostat, 10 mM in DMSO
- (S)-ethyl 2-amino-5-(((R)-3-(benzylthio)-1-(((S)-2-ethoxy-2-oxo-1-phenylethyl)amino)-1-oxopropan-2-yl)amino)-5-oxopentanoate
- Ezatiostat
- 168682-53-9
- C27H35N3O6S
