2-[1-(Ammoniocarbonyl)-3-(diisopropylammonio)-1-phenylpropyl)]pyridiniumphosphat
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- CAS-Nr.
- 22059-60-5
- Bezeichnung:
- 2-[1-(Ammoniocarbonyl)-3-(diisopropylammonio)-1-phenylpropyl)]pyridiniumphosphat
- Englisch Name:
- Disopyramid phosphate
- Synonyma:
- norpace;sc13957;RYTHMODAN;norpace cr;disopyramid phosphate;DISOPYRAMIDE PHOSPHATE;Disopyramide phosphate CRS;DISOPYRAMIDE PHOSPHATE SALT;Disopyramid phosphate USP/EP/BP;Disopyramide Phosphate (200 mg)
- CBNumber:
- CB7263617
- Summenformel:
- C21H32N3O5P
- Molgewicht:
- 437.47
- MOL-Datei:
- 22059-60-5.mol
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2-[1-(Ammoniocarbonyl)-3-(diisopropylammonio)-1-phenylpropyl)]pyridiniumphosphat Eigenschaften
- Schmelzpunkt:
- 202-204°C
- storage temp.
- 2-8°C
- L?slichkeit
- DMSO (Slightly, Heated, Sonicated), Methanol (Slightly), Water (Slightly)
- Aggregatzustand
- solid
- Farbe
- White to Off-White
- Major Application
- pharmaceutical (small molecule)
- InChI
- 1S/C21H29N3O.H3O4P/c1-16(2)24(17(3)4)15-13-21(20(22)25,18-10-6-5-7-11-18)19-12-8-9-14-23-19;1-5(2,3)4/h5-12,14,16-17H,13,15H2,1-4H3,(H2,22,25);(H3,1,2,3,4)
- InChIKey
- CGDDQFMPGMYYQP-UHFFFAOYSA-N
- SMILES
- C(CCN(C(C)C)C(C)C)(C1=NC=CC=C1)(C1=CC=CC=C1)C(=O)N.P(=O)(O)(O)O
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Kennzeichnung gef?hrlicher |
Xn |
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| R-S?tze: |
22 |
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| S-S?tze: |
36 |
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| WGK Germany |
3 |
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| RTECS-Nr. |
UR8440000 |
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| HS Code |
2933399090 |
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| Speicherklasse |
11 - Combustible Solids |
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| Hazard Classifications |
Acute Tox. 4 Oral |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
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P264, P270, P301+P312, P330, P501 |
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| Sicherheit |
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2-[1-(Ammoniocarbonyl)-3-(diisopropylammonio)-1-phenylpropyl)]pyridiniumphosphat Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R22:Gesundheitssch?dlich beim Verschlucken.
S-S?tze Betriebsanweisung:
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Verwenden
Cardiac depressant (anti-arrhythmic).
Allgemeine Beschreibung
Disopyramide phosphate, -[2(diisopropylamino)ethyl]- -phenyl-2-pyridineacetamidephosphate (Norpace), is an oral and intravenousclass IA antiarrhythmic agent. It is quite similar to quinidineand procainamide in its electrophysiological properties, inthat it decreases phase 4 diastolic depolarization, decreasesconduction velocity, and has vagolytic properties.31 It is usedclinically in the treatment of refractory, life-threatening ventriculartachyarrhythmias. Oral administration of the drugproduces peak plasma levels within 2 hours. The drug isbound approximately 50% to plasma protein and has a halflifeof 6.7 hours in humans. More than 50% is excretedunchanged in the urine. Therefore, patients with renal insufficiencyshould be monitored carefully for evidence ofoverdose. Disopyramide phosphate commonly exhibits sideeffects of dry mouth, constipation, urinary retention, andother cholinergic blocking actions because of its structuralsimilarity to anticholinergic drugs.
2-[1-(Ammoniocarbonyl)-3-(diisopropylammonio)-1-phenylpropyl)]pyridiniumphosphat Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
2-[1-(Ammoniocarbonyl)-3-(diisopropylammonio)-1-phenylpropyl)]pyridiniumphosphat Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 79)Lieferanten
22059-60-5(2-[1-(Ammoniocarbonyl)-3-(diisopropylammonio)-1-phenylpropyl)]pyridiniumphosphat)Verwandte Suche:
- DISOPYRAMIDE PHOSPHATE
- DISOPYRAMIDE PHOSPHATE SALT
- disopyramid phosphate
- ALPHA-DIISOPROPYLAMINOETHYL-ALPHA-PHENYLPYRIDINE-2-ACET-AMIDE PHOSPHATE SALT
- RYTHMODAN
- norpace cr
- 2-[1-(ammoniocarbonyl)-3-(diisopropylammonio)-1-phenylpropyl)]pyridinium phosphate
- 4-(diisopropylaMino)-2-phenyl-2-(pyridin-2-yl)butanaMide phosphate
- alpha-(2-(bis(1-methylethyl)amino)ethyl)-alpha-phenyl-2-pyridineacetamid
- alpha-(2-(diisopropylamino)ethyl)-alpha-phenyl-2-pyridineacetamidphosphate
- alpha-(2-diisopropylaminoethyl)-alpha-phenyl-2-pyridineacetamidephosphate
- norpace
- sc13957
- 2-Pyridineacetamide, .alpha.-2-bis(1-methylethyl)aminoethyl-.alpha.-phenyl-, phosphate (1:1)
- Disopyramide phosphate salt,α-Diisopropylaminoethyl-α-phenylpyridine-2-acetamide
- Disopyramide Phosphate (200 mg)
- Disopyramide phosphate CRS
- Disopyramid phosphate USP/EP/BP
- Disopyramide Phosphate (1222501)
- 22059-60-5
- C21H32N3O5P
- C21H29N3OH3PO4
- C21H29N3OH3O4PC21H32N3O5P
- C21H29N3OH3O4PC21H32N
- C21H29N3OH3O4P
- Other Sodium Channel Modulators
- Sodium Channel Modulators
- Voltage-gated Ion Channels
- Ion Channels
- Monovalent Ion Channels
- BioChemical
- Cell Signaling and Neuroscience
- Cell Biology
