一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

S)-1-(sec-butyl)-N-((4,6-diMethyl-2-oxo-1,2-dihydropyridin-3-yl)Methyl)-3-Methyl-6-(6-(piperazin-1-yl)pyridin-3-yl)-1H-indole-4-carboxaMide

S)-1-(sec-butyl)-N-((4,6-diMethyl-2-oxo-1,2-dihydropyridin-3-yl)Methyl)-3-Methyl-6-(6-(piperazin-1-yl)pyridin-3-yl)-1H-indole-4-carboxaMide Struktur
1346574-57-9
CAS-Nr.
1346574-57-9
Englisch Name:
S)-1-(sec-butyl)-N-((4,6-diMethyl-2-oxo-1,2-dihydropyridin-3-yl)Methyl)-3-Methyl-6-(6-(piperazin-1-yl)pyridin-3-yl)-1H-indole-4-carboxaMide
Synonyma:
GSK126;CS-694;SK 126;CPDB1065;GSK-2816126;GSK2816126A;GSK126, >=98%;GSK126 ，S7061;e-4-carboxamide;]-N-[(4,6-dimethyL
CBNumber:
CB72645671
Summenformel:
C31H38N6O2
Molgewicht:
526.67
MOL-Datei:
1346574-57-9.mol

S)-1-(sec-butyl)-N-((4,6-diMethyl-2-oxo-1,2-dihydropyridin-3-yl)Methyl)-3-Methyl-6-(6-(piperazin-1-yl)pyridin-3-yl)-1H-indole-4-carboxaMide Eigenschaften

Schmelzpunkt:
>216°C (dec.)
Siedepunkt:
823.4±65.0 °C(Predicted)
Dichte
1.25±0.1 g/cm3(Predicted)
storage temp. 
-20°C Freezer
L?slichkeit
DMSO (Slightly), Methanol (Slightly, Heated)
pka
11.93±0.10(Predicted)
Aggregatzustand
Solid
Farbe
Off-White
InChIKey
FKSFKBQGSFSOSM-QFIPXVFZSA-N
SMILES
N1([C@@H](C)CC)C2=C(C(C(NCC3=C(C)C=C(C)NC3=O)=O)=CC(C3=CC=C(N4CCNCC4)N=C3)=C2)C(C)=C1
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
HS Code  2933998090
Bildanzeige (GHS) Exclamation Mark (GHS07)
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitssch?dlich bei Verschlucken. Akute Toxizit?t oral Kategorie 4 Warnung P264, P270, P301+P312, P330, P501
H317 Kann allergische Hautreaktionen verursachen. Sensibilisierung der Haut Kategorie 1A Warnung P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
Sicherheit
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.

S)-1-(sec-butyl)-N-((4,6-diMethyl-2-oxo-1,2-dihydropyridin-3-yl)Methyl)-3-Methyl-6-(6-(piperazin-1-yl)pyridin-3-yl)-1H-indole-4-carboxaMide Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

The histone H3 lysine 27 (H3K27) methyltransferase EZH2 plays an important role in regulating gene expression, and its aberrant activity is linked to the onset and progression of cancer. GSK126 is a selective, S-adenosyl-methionine-competitive small molecule inhibitor of EZH2 methyltransferase activity (Ki = 0.57 nM; IC50 = 9.9 nM versus that of EZH1: Ki = 89 nM; IC50 = 680 nM). It is more than 1,000-fold selective for EZH2 over other histone methyltranferases, including both SET-domain-containing and non-SET-domain-containing methyltransferases. At concentrations of 7-252 nM, it has been shown to inhibit global H3K27 trimethylation levels and to reactivate silenced PRC2 target genes. Furthermore, GSK126 can inhibit the proliferation of EZH2 mutant DLBCL cell lines (IC50 = 28-61 nM) as well as the growth of EZH2 mutant DLBCL xenografts in mice receiving a daily dose of 50 mg/kg.

S)-1-(sec-butyl)-N-((4,6-diMethyl-2-oxo-1,2-dihydropyridin-3-yl)Methyl)-3-Methyl-6-(6-(piperazin-1-yl)pyridin-3-yl)-1H-indole-4-carboxaMide Upstream-Materialien And Downstream Produkte

Upstream-Materialien

1H-Indole-4-carboxaMide, 6-broMo-N-[(1,2-dihydro-4,6-diMethyl-2-oxo-3-pyridinyl)Methyl]-3-Methyl-1-[(1S)-1-Methylpropyl]- 2,5-Dibromo-3-nitro-benzoic acid 1H-Indole-4-carboxaMide,6-broMo-N-[(1,2-dihydro-4,6-diMethyl-2-oxo-3-pyridinyl)Methyl]-3-Methyl-1-(1-Methylpropyl)- 1-(5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDIN-2-YL)PIPERAZINE 2(1H)-Pyridinone, 3-(aminomethyl)-4,6-dimethyl- (9CI) 1H-Indole-4-carboxylic acid, 6-broMo-3-Methyl-1-(1-Methylpropyl)- 1H-Indole-4-carboxylic acid,6-broMo-1-(1-Methylpropyl)-,Methyl ester 2,5-Dibrombenzoesure 3-Nitro-o-toluylsure 5-BROMO-2-METHYL-3-NITROBENZOIC ACID

Downstream Produkte

S)-1-(sec-butyl)-N-((4,6-diMethyl-2-oxo-1,2-dihydropyridin-3-yl)Methyl)-3-Methyl-6-(6-(piperazin-1-yl)pyridin-3-yl)-1H-indole-4-carboxaMide Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 199)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795
ivan@atkchemical.com China 33024 60
career henan chemical co 		+86-0371-86658258 +8613203830695
 sales@coreychem.com China 29815 58
Biochempartner 		0086-13720134139
candy@biochempartner.com CHINA 965 58
BOC Sciences 		+1-631-485-4226
inquiry@bocsci.com United States 19936 58
TargetMol Chemicals Inc. 		+1-781-999-5354; +17819995354
 marketing@targetmol.com United States 32466 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226
 sales@hzclap.com CHINA 6312 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250
 1026@dideu.com China 20582 58
Hefei Hirisun Pharmatech Co., Ltd 		+8615056975894
 shawn@hirisunpharm.com CHINA 9911 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471;
 sales@sarms4muscle.com China 10473 58
InvivoChem 		+1-708-310-1919 +1-13798911105
 sales@invivochem.cn United States 6391 58
  • S)-1-(sec-butyl)-N-((4,6-diMethyl-2-oxo-1,2-dihydropyridin-3-yl)Methyl)-3-Methyl-6-(6-(piperazin-1-yl)pyridin-3-yl)-1H-indole-4-carboxaMide
  • N-[(4,6-Dimethyl-2-oxo-1,2-dihydro-3-pyridinyl)methyl]-3-methyl-1-((1S)-1-methylpropyl)-6-[6-(1-piperazinyl)-3-pyridinyl]-1H-indole-4-carboxamide
  • GSK126, >=98%
  • 1-(S)-sec-butyl-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3-methyl-6-(6-(piperazin-1-yl)pyridin-3-yl)-1H-indole-4-carboxamide
  • GSK 126 N-[(4,6-Dimethyl-2-oxo-1,2-dihydro-3-pyridinyl)methyl]-3-methyl-1-((1S)-1-methylpropyl)-6-[6-(1-piperazinyl)-3-pyridinyl]-1H-indole-4-carboxamide
  • N-[(4,6-Dimethyl-2-oxo-1,2-dihydro-3-pyridinyl)methyl]-3-methyl-1-((1S)-1-methylpropyl)-6-[6-(1-piperazinyl)-3-pyridinyl]-1H-indole-4-carboxamide GSK126
  • N-[(4,6-Dimethyl-2-ox
  • GSK126;GSK-126;GSK 126
  • GSK-2816126
  • CPDB1065
  • 1-[(2S)-butan-2-yl]-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-3-methyl-6-(6-piperazin-1-ylpyridin-3-yl)indole-4-carboxamide
  • CS-694
  • GSK126;S)-1-(SEC-BUTYL)-N-((4,6-DIMETHYL-2-OXO-1,2-DIHYDROPYRIDIN-3-YL)METHYL)-3-METHYL-6-(6-(PIPERAZIN-1-YL)PYRIDIN-3-YL)-1H-INDOLE-4-CARBOXAMIDE
  • EZH2 INHIBITOR;GSK-126;GSK 126;GSK2816126A
  • GSK2816126A
  • GSK126 (GSK2816126A)
  • (S)-1-(sec-butyl)-N-((4,6-diMethyl-2-oxo-1,2-dihydropyridin-3-yl)Methyl)-3-Methyl-6-(6-(piperazin-1-yl)pyridin-3-yl)-1H-indole-4-carboxaMide(GSK126)
  • ]-N-[(4,6-dimethyL
  • 1-[(2S)-butan-2-yL
  • -2-oxo-1H-pyridin-3-yL
  • -6-(6-piperazin-1-yL
  • e-4-carboxamide
  • SK 126
  • 1H-Indole-4-carboxamide, N-[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-3-methyl-1-[(1S)-1-methylpropyl]-6-[6-(1-piperazinyl)-3-pyridinyl]-
  • S)-1-(sec-butyl)-N-((4,6-diMethyl-2-oxo-1,2-dihydropyridin-3-yl)Methyl)-3-Methyl-6-(6-(piperazin-1-yl)pyridin-3-yl)-1H-indole-4-carboxaMide USP/EP/BP
  • GSK126 (GSK2816126
  • GSK126, EZH2 methyltransferase inhibitor
  • GSK126, 10 mM in DMSO
  • GSK126 ，S7061
  • GSK126
  • 1346574-57-9
  • 1345674-57-9
  • C31H38N6O2
  • Inhibitors
  • API
Copyright 2019 ? ChemicalBook. All rights reserved
专栏| 平南县| 疏勒县| 乌鲁木齐县| 平果县| 平阳县| 垫江县| 垫江县| 安远县| 合水县| 维西| 天全县| 界首市| 岳池县| 长垣县| 岳池县| 中宁县| 鲜城| 吉安县| 工布江达县| 兴国县| 望城县| 来宾市| 上思县| 金沙县| 朔州市| 宣武区| 永丰县| 体育| 西青区| 化德县| 句容市| 五莲县| 合水县| 丰县| 德安县| 新闻| 海口市| 金寨县| 台安县| 扎兰屯市|