GSK 2830371

1404456-53-6

CAS-Nr.: 1404456-53-6

Englisch Name:: GSK 2830371

Synonyma:: GSK 2830371;GSK 2830371 USP/EP/BP;GSK 2830371, 10 mM in DMSO;PPM1D Phosphatase Inhibitor II, GSK2830371;(S)-5-((5-chloro-2-methylpyridin-3-ylamino)methyl)-N-(3-cyclopentyl-1-(cyclopropylamino)-1-oxopropan-2-yl)thiophene-2-carboxamide;5-[[(5-Chloro-2-methyl-3-pyridinyl)amino]methyl]-N-[(1S)-1-(cyclopentylmethyl)-2-(cycloprpylamino)-2-oxoethyl]-2-thiophenecarboxamide;5-[[(5-Chloro-2-methyl-3-pyridinyl)amino]methyl]-N-[(1S)-1-(cyclopentylmethyl)-2-(cyclopropylamino)-2-oxoethyl]-2-thiophenecarboxamide;2-Thiophenecarboxamide, 5-[[(5-chloro-2-methyl-3-pyridinyl)amino]methyl]-N-[(1S)-1-(cyclopentylmethyl)-2-(cyclopropylamino)-2-oxoethyl]-;GSK 2830371 (S)-5-(((5-chloro-2-methylpyridin-3-yl)amino)methyl)-N-(3-cyclopentyl-1-(cyclopropylamino) -1-oxopropan-2-yl)thiophene-2-carboxamide

CBNumber:: CB72682001

Summenformel:: C23H29ClN4O2S

Molgewicht:: 461.02

MOL-Datei:: 1404456-53-6.mol

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Eigenschaften Sicherheit Verwendungswort Produktionsfirma 141

GSK 2830371 Eigenschaften

Siedepunkt:: 704.1±60.0 °C(Predicted)

Dichte: 1.30±0.1 g/cm3(Predicted)

storage temp.: 2-8°C

L?slichkeit: DMSO: soluble20mg/mL, clear

pka: 13.29±0.46(Predicted)

Aggregatzustand: powder

Farbe: white to beige

InChIKey: IVDUVEGCMXCMSO-FQEVSTJZSA-N

SMILES: [s]1c(ccc1C(=O)N[C@@H](CC4CCCC4)C(=O)NC3CC3)CNc2c(ncc(c2)Cl)C

Sicherheit

WGK Germany	3
Speicherklasse	11 - Combustible Solids

GSK 2830371 Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

GSK 2830371 is used in biological studies as allosteric Wip1(wild-type p54-induced phosphatase) inhibition through flap-subdomain interaction.

Biochem/physiol Actions

GSK2830371 is an orally active allosteric inhibitor of wild-type p53-induced phosphatase (Wip1, also known as PPM1D/ PP2Cδ), an oncogenic type 2C serine/threonine phosphatase that negatively regulates key proteins in the DNA damage–response pathway. GSK2830371 is selective for Wip1 with an IC50 of 6 nM against Wip1 compared to >10 μM IC50 for PPM1A & PPM1K, and >30 μM IC50 for 22 other phosphatases tested. GSK2830371 is believed to interact with the flap subdomain located near the Wip1 catalytic site, a feature that distinguishes Wip1 from other members of the protein phosphatase 2C (PP2C) family. GSK2830371 increased phosphorylation of Wip1 substrates and caused growth inhibition in both hematopoietic tumor cell lines and Wip1-amplified breast tumor cells harboring wild-type TP53.

GSK 2830371 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

2,5-Dichloro-3-nitropyridine 2-Thiophenecarboxylic acid, 5-[[(5-chloro-2-Methyl-3-pyridinyl)aMino]Methyl]- 3-Amino-5-chloropicoline (S)-tert-butyl (3-cyclopentyl-1-(cyclopropylaMino)-1-oxopropan-2-yl)carbaMate 5-Chloro-2-methyl-3-nitropyridine

Downstream Produkte

GSK 2830371 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 141)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
TargetMol Chemicals Inc.	+1-781-999-5354; +17819995354	marketing@targetmol.com	United States	32467	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	28509	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6391	58
HANGZHOU LEAP CHEM CO., LTD.	+86-571-87711850	market18@leapchem.com	China	24597	58
TargetMol Chemicals Inc.	+1-781-999-5354;	support@targetmol.com	United States	39040	58
Wuhan Topule Biopharmaceutical Co., Ltd	+8618327326525	masar@topule.com	China	8467	58
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd	+86-18341751992 +86-15382112998	757984502@qq.com	China	892	58
Aladdin Scientific		tp@aladdinsci.com	United States	57505	58
Wuhan Jingkang en Biomedical Technology Co., Ltd	+8613720134139	orders@jknbiochem.com	China	5221	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131956	58

GSK 2830371
5-[[(5-Chloro-2-methyl-3-pyridinyl)amino]methyl]-N-[(1S)-1-(cyclopentylmethyl)-2-(cyclopropylamino)-2-oxoethyl]-2-thiophenecarboxamide
(S)-5-((5-chloro-2-methylpyridin-3-ylamino)methyl)-N-(3-cyclopentyl-1-(cyclopropylamino)-1-oxopropan-2-yl)thiophene-2-carboxamide
GSK 2830371 USP/EP/BP
2-Thiophenecarboxamide, 5-[[(5-chloro-2-methyl-3-pyridinyl)amino]methyl]-N-[(1S)-1-(cyclopentylmethyl)-2-(cyclopropylamino)-2-oxoethyl]-
5-[[(5-Chloro-2-methyl-3-pyridinyl)amino]methyl]-N-[(1S)-1-(cyclopentylmethyl)-2-(cycloprpylamino)-2-oxoethyl]-2-thiophenecarboxamide
GSK 2830371 (S)-5-(((5-chloro-2-methylpyridin-3-yl)amino)methyl)-N-(3-cyclopentyl-1-(cyclopropylamino) -1-oxopropan-2-yl)thiophene-2-carboxamide
GSK 2830371, 10 mM in DMSO
PPM1D Phosphatase Inhibitor II, GSK2830371
1404456-53-6
C23H29ClN4O2S
Inhibitors

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