Cefditoren pivoxil
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- CAS-Nr.
- 117467-28-4
- Englisch Name:
- Cefditoren pivoxil
- Synonyma:
- CEFDITOREN;Spectracef;CEFDITORIN PIVOXIL;Meiac;Cefditoren Pivoxi;(6r-(3(z),6-alpha,7-beta-(z)))-dimethyl-1-oxopropoxy)methyleste;MEIACT;ME-1207;toubaotuolunzhi;toubaotuolkunzhi
- CBNumber:
- CB7377697
- Summenformel:
- C25H28N6O7S3
- Molgewicht:
- 620.72
- MOL-Datei:
- 117467-28-4.mol
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Cefditoren pivoxil Eigenschaften
- Schmelzpunkt:
- 207-209°C
- alpha
- D20 -48.5° (c = 0.5 in methanol)
- Dichte
- 1.55±0.1 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
- L?slichkeit
- DMSO (Slightly), Ethanol (Slightly), Methanol (Slightly, Heated)
- Aggregatzustand
- Solid
- pka
- 8.08±0.60(Predicted)
- Farbe
- Off-White to Pale Yellow
- Merck
- 14,1921
- InChIKey
- AFZFFLVORLEPPO-UVYJNCLZSA-N
- SMILES
- N12[C@@]([H])([C@H](NC(/C(/C3=CSC(N)=N3)=N\OC)=O)C1=O)SCC(/C=C\C1SC=NC=1C)=C2C(OCOC(=O)C(C)(C)C)=O
- CAS Datenbank
- 117467-28-4(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| WGK Germany |
WGK 3 |
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| RTECS-Nr. |
XI0367800 |
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| HS Code |
2941.90.3000 |
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| Speicherklasse |
11 - Combustible Solids |
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| Bildanzeige (GHS) |
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| Alarmwort |
Achtung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H317 |
Kann allergische Hautreaktionen verursachen. |
Sensibilisierung der Haut |
Kategorie 1A |
Warnung |
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P261, P272, P280, P302+P352,P333+P313, P321, P363, P501 |
| H334 |
Kann bei Einatmen Allergie, asthmaartige Symptome oder Atembeschwerden verursachen. |
Sensibilisierung der Atemwege |
Kategorie 1 |
Achtung |
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P261, P285, P304+P341, P342+P311,P501 |
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| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P272 |
Kontaminierte Arbeitskleidung nicht au?erhalb des Arbeitsplatzes tragen. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P285 |
Bei unzureichender Belüftung Atemschutz tragen. |
| P302+P352 |
BEI BERüHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckm??ig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen. |
| P304+P341 |
BEI EINATMEN: Bei Atembeschwerden an die frische Luft bringen und in einer Position
ruhigstellen, die das Atmen erleichtert |
| P321 |
Besondere Behandlung |
| P333+P313 |
Bei Hautreizung oder -ausschlag: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen. |
| P342+P311 |
Bei Symptomen der Atemwege: GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen. |
| P363 |
Kontaminierte Kleidung vor erneutem Tragen waschen. |
| P501 |
Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen. |
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Cefditoren pivoxil Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Cefditoren pivoxil is an orally active third generation cephalosporin introduced in Japan as a treatment for a broad range of bacterial infections including
dermatological and other community acquired infections. Cefditoren pivoxil is
reported to have a broad spectrum of activity against both Gram-positive and Gramnegative
bacteria, more potent than many other existing agents of its class. In
particular, it shows the highest therapeutic activity against S. pneumoniae and S.
marcescens infections. It exhibits resistance to β-lactamase hydrolysis typical of
third generation cephalosporins. As a prodrug of cefditoren, it is readily absorbed
through GI tract and has low toxicity and side effects.
Chemische Eigenschaften
Off-White Powder
Verwenden
Cefditoren Pivoxil is an antibacterial and is a third generation cephalosporin.
Definition
ChEBI: The pivaloyloxymethyl ester prodrug of cefditoren.
Antimicrobial activity
It exhibits good activity against staphylococci, streptococci
(but not enterococci), H. influenzae and M. catarrhalis, including
β-lactamase-producing strains. Isolates of Str. pneumoniae
exhibiting reduced susceptibility to penicillin are less susceptible
(MIC 0.125–2 mg/L). Most enterobacteria, including
many Enterobacter, Citrobacter, Serratia and Proteus spp., are
susceptible. It is not active against Ps. aeruginosa, Sten. maltophilia
or atypical respiratory pathogens such as Chlamydophila
pneumoniae and M. pneumoniae. It is stable to staphylococcal
and common enterobacterial β-lactamases.
Pharmakokinetik
Oral absorption: c. 70%
C
max 200 mg oral: c. 1.8 mg/L after 1.5–3 h
Plasma half-life: 0.8–1.3 h
Volume of distribution: 9.3 L
Plasma protein binding: 88%
After oral administration the pivaloyl ester is rapidly cleaved
by esterases in the gut wall. Ingestion with food improves
the bioavailability. Plasma concentrations are raised in
elderly patients. There is no accumulation on repeated
dosing.
It is excreted unchanged in the urine with a half-life of
around 1.5 h, achieving a concentration of 150–200 mg/L
within 4 h. Dosage adjustment is recommended in patients
with deteriorating renal function.
Clinical Use
It has been advocated for community-acquired upper and
lower respiratory tract infections and skin infections.
Nebenwirkungen
In common with other pivoxil esters it may cause carnitine
deficiency. Other side effects are those common to cephalosporins,
mainly gastrointestinal disturbance.
Cefditoren pivoxil Upstream-Materialien And Downstream Produkte
Upstream-Materialien
N,N-Diethylethanamin
5-Phenyl-1,3,4-oxadiazol-2(3H)-thion
Iodmethylpivalat
sodium (6R,7R)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyimino-acetyl]amino]-3-[(E)-2-(4-methyl-1,3-thiazol-5-yl)ethenyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Cefditoren
1,4,7,10,13,16-Hexaoxacycloocta-decan
N,N-Dimethylformamid
Natriumhydrogencarbonat
Downstream Produkte
Cefditoren pivoxil Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 369)Lieferanten
117467-28-4()Verwandte Suche:
- MEIACT
- ME-1207
- (6R,7R)-7-[[(2Z)-(2-Amino-4-thiazolyl)methoxyimino)acetyl]amino]-3-[(1Z)-2-(4-methyl-5-thiazolyl)ethenyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid Pivaloyloxymethyl Ester
- 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-3-[2-(4-methyl-5-thiazolyl)ethenyl]-8-oxo-, (2,2-dimethyl-1-oxopropoxy)methyl ester, [6R-[3(Z),6α,7β(Z)]]-
- 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2Z)-(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-3-[(1Z)-2-(4-methyl-5-thiazolyl)ethenyl]-8-oxo-, (2,2-dimethyl-1-oxopropoxy)methyl ester, (6R,7R)-
- ceditoren pivoxil
- Cefditoren pivoxyl
- CEFDITOREN PIVALOYLOXYMETHYL ESTER
- CEFDITOREN PIVOXIL
- CefditorenPivoxil,ME-1207,Meiact
- Cefditoren Pivoxil (350 mg)
- 2,2-Dimethylpropanoyloxymethyl (6R,7R)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-3-[(Z)-2-(4-methyl-1,3-thiazol-5-yl)ethenyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
- (6R,7R)-7-[[(2Z)-2-(2-amino-4-thiazolyl)-2-(methoxyimino)acetyl]amino]-3-[(1Z)-2-(4-methyl-5-thiazolyl)ethenyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid- (2,2-dimethyl-1-oxopropoxy)methyl ester
- (2,2-)(methoxyimino)acetyl)amino)-3-(2-(4-methyl-5-thiazolyl)ethenyl)-8-oxo
- Cefditoren Pivoxil (1097590)
- 4-Dihydroxy-5-methoxybenzoic acid
- toubaotuolunzhi
- toubaotuolkunzhi
- CEFDITOREN PIVOXYL;CEFDITOREN PIVALOYLOXYMETHYL ESTER;ME 1207
- Cefditoren Pivoxil >
- 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2Z)-2-(2-amino-4-thiazolyl)-2-(methoxyimino)acetyl]amino]-3-[(1Z)-2-(4-methyl-5-thiazolyl)ethenyl]-8-oxo-, (2,2-dimethyl-1-oxopropoxy)methyl ester, (6R,7R)-
- (6R,7R)-(pivaloyloxy)methyl7-((Z)-2-(2-aminothiazol-4-yl)-2-(methoxyimino)acetamido)-3-((Z)-2-(4-methylthiazol-5-yl)vinyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
- Cefditoren pivoxil USP/EP/BP
- Cefditoren pivoxil Impurity 25
- Cefditoren Pivoxil (Cefditoren pivoxyl)
- Meiac
- Spectracef
- CEFDITORIN PIVOXIL
- Cefditoren Pivoxil CRS
- Cefthoram pipivoxil
- Ceftoram pipivoxil
- Cefditoren pivoxil, 10 mM in DMSO
- Cefditoren Pivoxil RS
- (6r-(3(z),6-alpha,7-beta-(z)))-dimethyl-1-oxopropoxy)methyleste
- Cefditoren Pivoxi
- CEFDITOREN
- Cefotoluprimine API
- 117467-28-4
- C25H28N6O7S3
- CYMBALTA
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Sulfur & Selenium Compounds
- 117467-28-4
- Cefditoren
