Natrium-(6R-trans)-3-[[(5-methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-7-(1H-tetrazol-1-ylacetamido)-5-thia-1-azabicyclo[4.2.0]oct-2-en-2-carboxylat
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- CAS-Nr.
- 27164-46-1
- Bezeichnung:
- Natrium-(6R-trans)-3-[[(5-methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-7-(1H-tetrazol-1-ylacetamido)-5-thia-1-azabicyclo[4.2.0]oct-2-en-2-carboxylat
- Englisch Name:
- Cefazolin sodium salt
- Synonyma:
- CEFAZOLIN SODIUM;Cefazolin sodium sterile;kefzol;CEFAZOLINE SODIUM;ancef;Cefazoline sodium sterile;sodium 3-{[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]methyl}-8-oxo-7-[(1H-tetrazol-1-ylacetyl)amino]-5-thia-1-azabicyclo[4.2.0;46083;Atirin;Azolin
- CBNumber:
- CB7403213
- Summenformel:
- C14H15N8NaO4S3
- Molgewicht:
- 478.5
- MOL-Datei:
- 27164-46-1.mol
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Natrium-(6R-trans)-3-[[(5-methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-7-(1H-tetrazol-1-ylacetamido)-5-thia-1-azabicyclo[4.2.0]oct-2-en-2-carboxylat Eigenschaften
- Schmelzpunkt:
- 190 °C
- Brechungsindex
- 20 ° (C=10, H2O)
- storage temp.
- Keep in dark place,Inert atmosphere,2-8°C
- L?slichkeit
- H2O: 50 mg/mL, clear, colorless
- Aggregatzustand
- crystalline powder
- Farbe
- White to Off-White
- Optische Rotation
- -67.2°(C=0.01g/ml DMF)
- Sensitive
- Light Sensitive
- Merck
- 14,1917
- BRN
- 3585038
- Stabilit?t:
- Stable, but may be heat sensitive - store in cool conditions. May discolour upon exposure to light - store in the dark. Incompatible with strong oxidizing agents.
- InChIKey
- LJIOGPYKTPCRAP-MVOALHSDNA-N
- SMILES
- C(C1=C(CS[C@]2([H])[C@H](NC(=O)CN3N=NN=C3)C(=O)N12)CSC1=NN=C(C)S1)(=O)O.[NaH] |&1:5,7,r|
- LogP
- 1.133 (est)
- CAS Datenbank
- 27164-46-1(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Kennzeichnung gef?hrlicher |
Xn,Xi |
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| R-S?tze: |
42/43-36/37/38-20/21/22 |
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| S-S?tze: |
22-36/37-36-26 |
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| WGK Germany |
2 |
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| RTECS-Nr. |
XI0390000 |
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| HS Code |
29349990 |
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| Speicherklasse |
11 - Combustible Solids |
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| Hazard Classifications |
Resp. Sens. 1
Skin Sens. 1 |
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| Toxizit?t |
LD50 in mice, rats (mg/kg): 3.9, 3.18 i.v.; 6.2, 7.4 i.p. (Birkhead) |
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| Bildanzeige (GHS) |
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| Alarmwort |
Achtung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H317 |
Kann allergische Hautreaktionen verursachen. |
Sensibilisierung der Haut |
Kategorie 1A |
Warnung |
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P261, P272, P280, P302+P352,P333+P313, P321, P363, P501 |
| H334 |
Kann bei Einatmen Allergie, asthmaartige Symptome oder Atembeschwerden verursachen. |
Sensibilisierung der Atemwege |
Kategorie 1 |
Achtung |
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P261, P285, P304+P341, P342+P311,P501 |
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| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P342+P311 |
Bei Symptomen der Atemwege: GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen. |
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Natrium-(6R-trans)-3-[[(5-methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-7-(1H-tetrazol-1-ylacetamido)-5-thia-1-azabicyclo[4.2.0]oct-2-en-2-carboxylat Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R42/43:Sensibilisierung durch Einatmen und Hautkontakt m?glich.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R20/21/22:Gesundheitssch?dlich beim Einatmen,Verschlucken und Berührung mit der Haut.
S-S?tze Betriebsanweisung:
S22:Staub nicht einatmen.
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
Beschreibung
Cefazolin was synthesized by Fujisawa Pharmaceutical Co. in 1969. It was the first of the cephem antibiotics to introduce a thiadiazolylthiomethyl group at the 3 position and a tetrazole group at the 7 position in the side chain. Cefazolin is a parenteral cephem antibiotic showing better activity against gramnegative bacteria than cephalothin or cephaloridine. Its bactericidal activity, tissue distribution, and urinary excretion are excellent and it has wide clinical use.
Chemische Eigenschaften
White to off-white powder
Verwenden
Semi-synthetic antibiotic derived from 7-amino-cepphalosporanic acid. An antibacterial
Definition
ChEBI: A cephalosporin organic sodium salt having [(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]methyl and (1H-tetrazol-1-ylacetyl)amino side-groups.
Clinical Use
Cefazolin (Ancef, Kefzol) is one of a series of semisyntheticcephalosporins in which the C-3 acetoxy function has beenreplaced by a thiol-containing heterocycle—here, 5-methyl-2-thio-1,3,4-thiadiazole. It also contains the somewhatunusual tetrazolylacetyl acylating group. Cefazolin wasreleased in 1973 as a water-soluble sodium salt. It is activeonly by parenteral administration.
Cefazolin provides higher serum levels, slower renalclearance, and a longer half-life than other first-generationcephalosporins. It is approximately 75% protein bound inplasma, a higher value than for most other cephalosporins.Early in vitro and clinical studies suggest that cefazolin ismore active against Gram-negative bacilli but less activeagainst Gram-positive cocci than either cephalothin orcephaloridine. Occurrence rates of thrombophlebitis followingintravenous injection and pain at the site of intramuscularinjection appear to be the lowest of the parenteralcephalosporins.
Natrium-(6R-trans)-3-[[(5-methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-7-(1H-tetrazol-1-ylacetamido)-5-thia-1-azabicyclo[4.2.0]oct-2-en-2-carboxylat Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Natrium-(6R-trans)-3-[[(5-methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-7-(1H-tetrazol-1-ylacetamido)-5-thia-1-azabicyclo[4.2.0]oct-2-en-2-carboxylat Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 513)Lieferanten
27164-46-1(Natrium-(6R-trans)-3-[[(5-methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-7-(1H-tetrazol-1-ylacetamido)-5-thia-1-azabicyclo[4.2.0]oct-2-en-2-carboxylat)Verwandte Suche:
- (6r-trans
- SKF-41558
- CEFAZOLIN NA
- CEFAZOLIN SODIUM SALT
- CEFAMEDIN
- biazolina
- cezsodium
- firmacef
- gramaxin
- lampocef
- liviclina
- monosodiumcefazolin
- sodiumcefazolin
- sodiumcephazolin
- sodiumcez
- totacef
- zolicef
- sodium (6R-trans)-3-[[(5-methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-7-(1H-tetrazol-1-ylacetamido)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
- (6R,7R)-3-[[(5-Methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-7-[(1H-tetrazol-1-ylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid Sodium Salt
- Cefazil
- Cefazil sodium salt, Cefamedin sodium salt
- Monosodium cetazolin
- DBL Cephazolin Sodium For Injection
- (6R,7R)-3-[[(5-Methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-7-[2-(1H-tetrazol-1-yl)acetylamino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid sodium salt
- (6R,7R)-7-[1H-Tetrazol-1-ylacetylamino]-3-[(5-methyl-1,3,4-thiadiazol-2-yl)thiomethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid sodium salt
- 46083
- Atirin
- Azolin
- Bor-Cefazol
- Cefacidal
- Cefazina
- Cefazoliin
- Cefazolin SodiuM Steril
- 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid,3-[[(5-Methyl-1,3,4-thiadiazol-2-yl)thio]Methyl]-8-oxo-7-[[2-(1H-tetrazol-1-yl)acetyl]aMino]-,sodiuM salt (1:1), (6R,7R)-
- Cefazolin Sodium IMP
- Cefazolin sodium salt, 95%, a first-generation cephalosporin antibiotic
- Cefazolin Sodium Salt >
- Cefazolin Sodium Salt Standard
- cephazolin sodium
- Cefazolin sodium (Sodium cefazolin
- Sodium (6R,7R)-7-(2-(1H-tetrazol-1-yl)acetamido)-3-(((5-methyl-1,3,4-thiadiazol-2-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
- Cefazolin sodium salt USP/EP/BP
- Cefazolin Sodium, Ancef
- Cefazolin Sodium (cefazoline
- Cefazolin sodiumQ: What is
Cefazolin sodium Q: What is the CAS Number of
Cefazolin sodium Q: What is the storage condition of
Cefazolin sodium
- Cefazolin sodium API
- Cefazolin Sodium Salt (CFZL), 89-110%
- ancef
- Cefazoline sodium sterile
- sodium 3-{[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]methyl}-8-oxo-7-[(1H-tetrazol-1-ylacetyl)amino]-5-thia-1-azabicyclo[4.2.0
- Brizolina
- Cefazolin Sodium Impurity L (Sodium Salt)
- Cefazolin sodium, 10 mM in DMSO
- Cefazolin sodium (Standard)
- CEFAZOLIN SODIUM
- Cefazolin sodium sterile
- CEFAZOLINE SODIUM
- kefzol
