TYRPHOSTIN AG 1296
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- CAS-Nr.
- 146535-11-7
- Englisch Name:
- TYRPHOSTIN AG 1296
- Synonyma:
- 1296;AG 1296;A 1296;AG-1296;AG 1296;;TYRPHOSTIN AG 1296;Tyrphostin AG 1296 ，S8024;TYRPHOSTIN AG 1296 USP/EP/BP;Tyrphostin AG 1296 (AG 1296);AG-1296
(Tyrphostin AG 1296);Tyrphostin AG1296, 10 mM in DMSO
- CBNumber:
- CB7435034
- Summenformel:
- C16H14N2O2
- Molgewicht:
- 266.29
- MOL-Datei:
- 146535-11-7.mol
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TYRPHOSTIN AG 1296 Eigenschaften
- Siedepunkt:
- 420.2±40.0 °C(Predicted)
- Dichte
- 1.192±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Store in freezer, under -20°C
- L?slichkeit
- Soluble in DMSO.
- pka
- 0.48±0.30(Predicted)
- Aggregatzustand
- White solid
- Farbe
- Yellow
- Sensitive
- Light Sensitive
- Stabilit?t:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
- InChI
- 1S/C16H14N2O2/c1-19-15-8-12-13(9-16(15)20-2)18-14(10-17-12)11-6-4-3-5-7-11/h3-10H,1-2H3
- InChIKey
- QNOXYUNHIGOWNY-UHFFFAOYSA-N
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| WGK Germany |
3 |
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| Speicherklasse |
11 - Combustible Solids |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
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P264, P270, P301+P312, P330, P501 |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
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P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
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P264, P280, P305+P351+P338,P337+P313P |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizit?t (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
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| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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TYRPHOSTIN AG 1296 Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Protein tyrosine kinase (PTK) inhibitors are potential antiproliferative agents for diseases caused by the hyperactivity of PTKs. Tyrphostins are a class of antiproliferative compounds which act as PTK blockers. PTK inhibitors specific for platelet-
derived growth factor (PDGF) receptor kinase could help in the treatment of atherosclerosis, restenosis, pulmonary fibrosis, and gliomas. AG-
1296 is a potent and selective inhibitor of PDGF receptor kinase with an IC
50 value of about 0.4 μM both
in vitro and in cells (Swiss 3T3 cells). It inhibits ligand-
stimulated DNA synthesis in platelet-
derived growth factor receptor and stem cell factor/kit receptor transfected cells with an IC
50 values of 1.5 and 1.8 μM, respectively. Treatment of sis oncogene transfected NIH3T3 cells with AG-
1296 reverses the transformed phenotype.
Verwenden
Tyrphostin AG 1296, is the platelet-derived growth factor receptor (PDGFR) inhibitor, which can causes growth inhibition in glioblastoma cells.
TYRPHOSTIN AG 1296 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
TYRPHOSTIN AG 1296 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 123)Lieferanten
146535-11-7()Verwandte Suche:
- TYRPHOSTIN AG 1296
- AG 1296
- 6,7-DIMETHOXY-2-PHENYLQUINOXALINE
- 6,7-DIMETHOXY-3-PHENYLQUINOXALINE
- Quinoxaline,6,7-dimethoxy-2-phenyl-
- AG-1296;AG 1296;
- AG 1296 - CAS 146535-11-7 - Calbiochem
- AG-1296
(Tyrphostin AG 1296)
- Tyrphostin AG 1296 (AG 1296)
- 1296
- TYRPHOSTIN AG 1296 USP/EP/BP
- Fms like tyrosine kinase 3,PDGF,Apoptosis,CD117,inhibit,platelet-derived,CD135,SCFR,Tyrphostin AG-1296,c-Kit,PDGFR,FLT3,cell,AG1296,growth,stem,Inhibitor,Tyrphostin AG1296,Cluster of differentiation antigen 135,AG-1296,factor,Platelet-derived growth factor receptor
- A 1296
- AG 1296, protein tyrosine kinase inhibitor
- Tyrphostin AG1296, 10 mM in DMSO
- Tyrphostin AG 1296 ，S8024
- 146535-11-7
- BioChemical
- Cell Biology
- Cell Signaling and Neuroscience
- Receptor Tyrosine Kinase Inhibitors
- Platelet Derived Growth Factor Receptor (PDGFR)
- Kinase/Phosphatase Biology
- Inhibitors
