Memantine
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- CAS-Nr.
- 19982-08-2
- Englisch Name:
- Memantine
- Synonyma:
- C13736;1-Amino-3,5-dimethyladamantane;(1r,3R,5S,7r)-3,5-dimethyladamantan-1-amine;MEMANTINE;AKOS BB-9600;AURORA KA-7643;Memantine(Base);7-DIMETHYLXANTHINE;TIMTEC-BB SBB002574;Memantine USP/EP/BP
- CBNumber:
- CB7436657
- Summenformel:
- C12H21N
- Molgewicht:
- 179.3
- MOL-Datei:
- 19982-08-2.mol
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Memantine Eigenschaften
- Schmelzpunkt:
- 258 °C
- Siedepunkt:
- 239.8±8.0 °C(Predicted)
- Dichte
- 1.046
- Brechungsindex
- nD25 1.4941
- storage temp.
- Keep in dark place,Inert atmosphere,2-8°C
- L?slichkeit
- Chloroform (Slightly), DMSO (Slightly)
- Aggregatzustand
- Solid
- pka
- 10.79±0.60(Predicted)
- Farbe
- Colorless Oil to Off-White Waxy
- BCS Class
- 1
- InChI
- InChI=1S/C12H21N/c1-10-3-9-4-11(2,6-10)8-12(13,5-9)7-10/h9H,3-8,13H2,1-2H3
- InChIKey
- BUGYDGFZZOZRHP-UHFFFAOYSA-N
- SMILES
- C12(N)CC3(C)CC(CC(C)(C3)C1)C2
- CAS Datenbank
- 19982-08-2(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Warnung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
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P264, P270, P301+P312, P330, P501 |
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| Sicherheit |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P270 |
Bei Gebrauch nicht essen, trinken oder rauchen. |
| P301+P312 |
BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen. |
| P330 |
Mund ausspülen. |
| P501 |
Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen. |
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Memantine Chemische Eigenschaften,Einsatz,Produktion Methoden
S-S?tze Betriebsanweisung:
S24/25:Berührung mit den Augen und der Haut vermeiden.
History
Memantine was first synthesized, patented, and described by Eli Lilly and Company in 1963 as an anti-diabetic agent, but it was ineffective at lowering blood sugar. By 1972, it was discovered to have central nervous system (CNS) activity, and was developed by Merz for treatment of neurological diseases, such as Parkinson's disease. Memantine was first studied in the treatment of Alzheimer's disease in 1986.
The drug was first marketed for dementia in 1989 in Germany under the name Axura. Memantine was approved in the European Union in 2002 and in the United States in 2003.
Verwenden
Recent phase 3 clinical trials have shown that Memantine is an effective way of treatment of both mild and moderate-to-severe Alzheimer''s disease and possibly vascular dementia (multi-infarct dementia). Memantine’s method of action involves an uncompetitive, low-affinity, open-channel blocker; it enters the receptor-associated ion channel preferentially when it is excessively open, and, most importantly, its off-rate is relatively fast so that it does not substantially accumulate in the channel to interfere with normal synaptic transmission.
Definition
ChEBI: A primary aliphatic amine that is the 3,5-dimethyl derivative of 1-aminoadamantane. A low to moderate affinity uncompetitive (open-channel); NMDA receptor antagonist which binds preferentially to the NMDA receptor-operated cation channels.
Biologische Aktivit?t
An antagonist at the NMDA receptor, binding to the ion channel site. Used in the treatment of Parkinsonism.
Memantine Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Memantine Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 210)Lieferanten
19982-08-2()Verwandte Suche:
- AKOS BB-9600
- MEMANTINE
- AURORA KA-7643
- TIMTEC-BB SBB002574
- 3,5-dimethyladamantan-1-amine HCl
- 3,5-Dimethyl-1-aminoadamantane
- 1,3-Dimethylaminoadamantane
- 3,5-DIMETHYL-1-AMINOADAMANTANE(MEMANTINE)
- 3,5-Dimethyltricyclo(3.3.1.1(3,7))decan-1-amine
- Tricyclo[3.3.1.13,7]decan-1-aMine,3,5-diMethyl-
- memantine(3,5-dimethyl-1-adamantanamine)
- MEMENTINE HYDROCHHLORIDE
- 1-Adamantanamine, 3,5-dimethyl-
- 3,5-Dimethyltricyclo(3.3.1.1(sup 3,7))decan-1-amine
- Tricyclo(3.3.1.1(sup 3,7))decan-1-amine, 3,5-dimethyl-
- Acid salts MeMantine
- 1,3-dimethyl-2-adamantanamine
- Memantine USP/EP/BP
- Memantine hydrochlor
- 3,5-dimethyl adamantine
- 7-DIMETHYLXANTHINE
- C13736
- Memantine (amantadine)
- Memantine(Base)
- Mouse Memantine ELISA Kit
- (1R,3R,5S,7R)-3,5-Dimethyladamantan-1-ylamine
- (1r,3R,5S,7r)-3,5-dimethyladamantan-1-amine
- 1-Amino-3,5-dimethyladamantane
- 19982-08-2
- GASTERIL
- Elisa Kit-Mouse Elisa Kit
