Ceftizoxime sodium
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- CAS-Nr.
- 68401-82-1
- Englisch Name:
- Ceftizoxime sodium
- Synonyma:
- Cefizox;fk749;Ceftix;Eposerin;Ceftizon;fr-13,479;skf-88373;SKF-88373-Z;Cefazoxime sodium;ceftizoxim-natrium
- CBNumber:
- CB7452781
- Summenformel:
- C13H14N5NaO5S2
- Molgewicht:
- 407.39
- MOL-Datei:
- 68401-82-1.mol
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Ceftizoxime sodium Eigenschaften
- Schmelzpunkt:
- 227℃
- RTECS-Nr.
- XI0368000
- storage temp.
- -20°C
- L?slichkeit
- DMSO: soluble1mg/mL
- Aggregatzustand
- solid
- Farbe
- white to faint yellow
- Wasserl?slichkeit
- Soluble in water
- Stabilit?t:
- Unstable in Solution
- InChIKey
- IYYQWKATOXYCHY-SFXQLROPNA-N
- SMILES
- O=C1[C@@H](NC(=O)/C(/C2N=C(N)SC=2)=N\OC)[C@@]2([H])SCC=C(C(=O)O)N12.[NaH] |&1:2,16,r|
- CAS Datenbank
- 68401-82-1(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Kennzeichnung gef?hrlicher |
Xi |
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| R-S?tze: |
36/37/38 |
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| S-S?tze: |
26 |
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| WGK Germany |
3 |
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| Speicherklasse |
11 - Combustible Solids |
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| Hazard Classifications |
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
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| Toxizit?t |
LD50 in mice, rats (mg/kg): ~6000 i.v. (Fukuhara) |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
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P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
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P264, P280, P305+P351+P338,P337+P313P |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizit?t (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
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| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P271 |
Nur im Freien oder in gut belüfteten R?umen verwenden. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P302+P352 |
BEI BERüHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckm??ig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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Ceftizoxime sodium Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Ceftizoxime was synthesized by Fujisawa Pharmaceutical Industries in 1979. It possesses the (iminothiazolyl)methoxyiminomethyl group at the 7 position of the cephem nucleus, but there is no side chain at the 3 position. The compound shows excellent activity against gram-positive and gram-negative bacteria, behavior similar to that of cefotaxime. Unlike cefotaxime, however, it is not metabolized in vivo.
Chemische Eigenschaften
Cefotaxime Sodium is white, white or light yellow crystalline powder; odorless; insoluble in organic solvents but soluble in water. The 10% solution has a pH of 4.5 to 6.5. Dilute solution is colorless or yellowish while high-concentration solution is grayish yellow. Dark yellow or brown color indicates that the drug has been deteriorated. The aqueous solution can be stored at 5 ℃ for 1 week.
Verwenden
Antibacterial.
Definition
ChEBI: The sodium salt of ceftizoxime.
Clinical Use
Ceftizoxime (Cefizox) is a third-generation cephalosporinthat was introduced in 1984. This β-lactamase–resistant agentexhibits excellent activity against the Enterobacteriaceae,especially E. coli, K. pneumoniae, E. cloacae, Enterobacteraerogenes, indole-positive and indole-negative Proteus spp.,and S. marcescens. Ceftizoxime is claimed to be more activethan cefoxitin against B. fragilis. It is also very active againstGram-positive bacteria. Its activity against P. aeruginosa issomewhat variable and lower than that of either cefotaxime orcefoperazone.
Ceftizoxime is not metabolized in vivo. It is excretedlargely unchanged in the urine. Adequate levels of the drugare achieved in the cerebrospinal fluid for the treatment ofGram-negative or Gram-positive bacterial meningitis. It mustbe administered on a thrice-daily dosing schedule because ofits relatively short half-life. Ceftizoxime sodium is very stablein the dry state. Solutions maintain potency for up to 24hours at room temperature and 10 days when refrigerated.
Ceftizoxime sodium Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Ceftizoxime sodium Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 294)Lieferanten
68401-82-1()Verwandte Suche:
Acetylchlorid
Natriumhydrogencarbonat
Ceftizoxime
N,N'-Ethylenbis[N-acetylacetamid]
Natriumchlorid
Natriumacetat
Benzothiazol
Natriumformiat
Natriumgluconat
Natriumcarbonat
2,4-Pentandion
4,4'-Diacetylbiphenyl
Reaktionsgemisch, bestehend aus5-Chlor-2-methyl-2H-isothiazol-3-on und 2-Methyl-2H-isothiazol-3-on (3:1)
Ethyl-N-acetyl-L-tyrosinat
Natriumbenzoat
Natriumhydroxid
5-Thia-1-azabicyclo[4.2.0]oct-2-en-2-carbonsure, 7-[[(2-Amino-4-thiazolyl)(methoxyimino)acetyl]amino]-8-oxo-3-[[(1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-1,2,4-triazin-3-yl)thio]methyl]-, Dinatriumsalz, [6R-[6α,7β(Z)]]-
Sauerstoff
- Ceftix
- Ceftizoxime, sodium salt
- 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-8-oxo-, monosodium salt, [6R-[6α,7β(Z)]]-
- 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2Z)-(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-8-oxo-, monosodium salt, (6R,7R)-
- Ceftizon
- Eposerin
- Sodium 7-[2-(2-aminothiazol-4-yl)-2-methoxyiminoacetamido]-3-cephem-4-carboxylate
- monosodium salt, (6r-(6-alpha,7-beta(z)))- (methoxyimino)acetyl)amino)-8-oxo-,
- Monosodium(6R,7R)-7-[[(2-aminothiazol-4yl)-2-methoxyiminoacetylamino]-8-oxo-5-thia-1-azabicyclo[4,2,0]oct-2-ene-2-Carboxylate
- (6r,7r)-7-[[(2z)-(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid sodium salt
- CEFTIZOXIMESODIUM(MONOSODIUM(6R,7R)-7-[[(2-AMINOTHIAZOL-4YL)-2-METHOXYIMINOACETYLAMINO]-8-OXO-5-THIA-1-AZABICYCLO[4,2,0]OCT-2-ENE-2-CARBOXYLATE)
- SKF-88373-Z
- Ceftizoxime sodiumUSP,
850-995 ug (HPLC)
- ceftizoxim-natrium
- fk749
- fr-13,479
- skf-88373
- CEFTIZOXIME SODIUM
- )-(methoxyimino)acetyl)amino)-8-oxo-,monosodiumsalt,(6r-(6-alpha,7-beta(z))
- sodium 7-[[2-(2-amino-4-thiazolyl)-2-methoxyimino-1-oxoethyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
- sodium (6R,7R)-7-((Z)-2-(2-aminothiazol-4-yl)-2-(methoxyimino)acetamido)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
- Ceftizoxime sodium USP/EP/BP
- Ceftizoxime sodiumQ: What is
Ceftizoxime sodium Q: What is the CAS Number of
Ceftizoxime sodium Q: What is the storage condition of
Ceftizoxime sodium
- TIANFUCHEM--68401-82-1--Ceftizoxime sodium
- Cefizox
- Monosodium Salt, Ceftizoxime
- Cefazoxime sodium
- 2-Propen-1-one,1-[(2S,5S)-2-(hydroxymethyl)-5-(7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-1-piperidinyl]-
- Ceftizoxime sodium salt[A3612]
- 68401-82-1
- 68401-81-1
- 3194-64-1
- C13H12N5NaO5S2
- C13H12N5O5S2Na
