Thymopentin
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- CAS-Nr.
- 69558-55-0
- Englisch Name:
- Thymopentin
- Synonyma:
- TP-5;RKDVY;Immunox;Timunox;ORF-15244;THYMOPETIN;Thyopentin;THYMOPENTIN;Thymopentine;ThymopentinⅡ
- CBNumber:
- CB7491069
- Summenformel:
- C30H49N9O9
- Molgewicht:
- 679.77
- MOL-Datei:
- 69558-55-0.mol
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Thymopentin Eigenschaften
- Dichte
- 1.44±0.1 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
- L?slichkeit
- DMF: 30 mg/ml; DMSO: 25 mg/ml; Ethanol: 1 mg/ml; PBS (pH 7.2): 10 mg/ml
- pka
- 3.07±0.10(Predicted)
- Aggregatzustand
- Powder
- Farbe
- White
- Sequenz
- Arg-Lys-Asp-Val-Tyr
- InChIKey
- PSWFFKRAVBDQEG-YGQNSOCVSA-N
- SMILES
- O=C([C@H](CC(O)=O)NC([C@H](CCCCN)NC([C@H](CCCNC(N)=N)N)=O)=O)N[C@@H](C(C)C)C(N[C@H](C(O)=O)CC1C=CC(=CC=1)O)=O
- CAS Datenbank
- 69558-55-0(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| WGK Germany |
3 |
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| HS Code |
3504009000 |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
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P264, P270, P301+P312, P330, P501 |
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| Sicherheit |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P270 |
Bei Gebrauch nicht essen, trinken oder rauchen. |
| P301+P312 |
BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen. |
| P330 |
Mund ausspülen. |
| P501 |
Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen. |
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Thymopentin Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Thymopentin is a kind of peptide. Peptides and polypeptides play a critical role in the immune system and are therefore predestined as a source for new approaches in immunotherapy. Thymopentin is capable of modulating the immune response. It is a fragment of the thymopoietins (TMPOs) which is a family of nuclear protein. Studies have shown that Thymopentin is capable of affecting the function of T cells and monocytes monitored by increased cGMP level and the triggering of cellular signaling. It is also capable of improve an imbalanced immune system. As an immunomodulating agent, it is clinically used in the treatment of autoimmune diseases such as atopic dermatitis, chronic lymphocytic leukemia, Sezary’s syndrome, rheumatoid arthritis and decreased immune competency. Recent study has also shown that its immuno-modulating effect can also help fight against the infection of mycobacterium tuberculosis.
Verwenden
Thymopentin Acetate (TP-5) is a synthetic immunomodulating pentapeptide.
Clinical Use
Thymopentin is a synthetic, immunomodulating pentapeptide, representing the
active fragment of the thymus hormone, thymopoietin. Thymopentin induces
phenotypic differentiation and maturation of T-cells. It appears of value in the
treatment of primary immune deficiency, rheumatoid arthritis, atopic dermatitis,
sarcoidosis and a variety of other diseases with manifestations of disturbed
immune balance.
Einzelnachweise
Zhang, Yan, et al. "Novel thymopentin release systems prepared from bioresorbable PLA–PEG–PLA hydrogels." International journal of pharmaceutics 386.1 (2010): 15-22.
Gonser, S., E. Weber, and G. Folkers. "Peptides and polypeptides as modulators of the immune response: thymopentin—an example with unknown mode of action." Pharmaceutica Acta Helvetiae 73.6 (1999): 265-273.
Wang, Ying, et al. "Synthetic modifications of the immunomodulating peptide thymopentin to confer anti-mycobacterial activity." Biomaterials 35.9 (2014): 3102-3109.
Thymopentin Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Thymopentin Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 486)Lieferanten
69558-55-0()Verwandte Suche:
- 32-36-Thymopoietin
- L-Arg-L-Lys-L-Asp-L-Val-L-Tyr-OH
- Thymopoietin II-(32-36)
- ThyMopentin for Injection
- TP-5
- THYMOPENTIN
- THYMOPENTIN 5
- THYMOPOIETIN (32-36) (HUMAN, MOUSE)
- THYMOPOIETIN II FRAGMENT (32-36)
- THYMOPOIETIN I/II (32-36) (BOVINE)
- THYMOPOIETIN PENTAPEPTIDE
- Immunox
- Sintomodulina
- Thymopentin-FITC
- Thymopoietin 32-36
- Timunox
- ARG-LYS-ASP-VAL-TYR
- (ASP34)-THYMOPOIETIN III (32-36) (BOVINE)
- H-ARG-LYS-ASP-VAL-TYR-OH
- RKDVY
- TP-5（Thymopentin）
- Thymopentin TP-5
- Thymopentine
- THYMOPETIN
- Arg-Lys-Asp-Val-Tyr-OH
- Thymopoietin pentapeptide-Fluorescin-isothiocyanate
- thymopentin pentapeptide
- Thyopentin
- Thymopent njection
- ThymopentinⅡ
- Sibuxintramine
- TP-5 / Thymopentin GMP (CFDA) CAS
- L-Tyrosine, L-arginyl-L-lysyl-L-α-aspartyl-L-valyl-
- (6S,9S,12S,15S,18S)-1,6-Diamino-9-(4-aminobutyl)-12-(carboxymethyl)-18-(4-hydroxybenzyl)-1-imino-15-isopropyl-7,10,13,16-tetraoxo-2,8,11,14,17-pentaazanonadecan-19-oic acid
- Thymopentin USP/EP/BP
- NH2-RKDVY-OH
- 69558-55-0 Thymopentin
- Thymopeptide
- ORF 15244 ORF15244
- ORF-15244
- TP 5 Thymopoietin pentapeptide
- Winstrol Stanozolol 10mg Tablets
- Thymopentin, 10 mM in DMSO
- THYMOPENTIN 97~103%
- 69558-55-0
- 9558-55-0
- C30H49N9O9
- C265H397O67N73
- BioChemical
- Amino Acids and Peptides
- Biochemicals and Reagents
- Peptides
- Other Peptides
- 多肽
- Inhibitors
- IMMUNOX
- Peptide
- Amino Acid Derivatives
