CHLORISONDAMINE DIIODIDE
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- CAS-Nr.
- 96750-66-2
- Englisch Name:
- CHLORISONDAMINE DIIODIDE
- Synonyma:
- Chlorisondamine (iodide);CHLORCHLORISONDAMINE DIIODIDEISONDAMINE DIIODIDE;4,5,6,7-tetrachloro-2-methyl-2-[2-(trimethylammonium)ethyl]isoindolinium diiodide
- CBNumber:
- CB7497364
- Summenformel:
- C14Cl4H20I2N2
- Molgewicht:
- 611.94
- MOL-Datei:
- 96750-66-2.mol
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CHLORISONDAMINE DIIODIDE Eigenschaften
- storage temp.
- 2-8°C
- L?slichkeit
- H2O: ~3.75 mg/mL
- Aggregatzustand
- solid
- Farbe
- white
- Wasserl?slichkeit
- Soluble to 10 mM in water
- InChI
- 1S/C14H20Cl4N2.2HI/c1-19(2,3)5-6-20(4)7-9-10(8-20)12(16)14(18)13(17)11(9)15;;/h5-8H2,1-4H3;2*1H/q+2;;/p-2
- InChIKey
- FPNVAOZHQUJJJQ-UHFFFAOYSA-L
- SMILES
- [I-].[I-].C[N+](C)(C)CC[N+]1(C)Cc2c(Cl)c(Cl)c(Cl)c(Cl)c2C1
CHLORISONDAMINE DIIODIDE Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R22:Gesundheitssch?dlich beim Verschlucken.
R50:Sehr giftig für Wasserorganismen.
S-S?tze Betriebsanweisung:
S60:Dieses Produkt und sein Beh?lter sind als gef?hrlicher Abfall zu entsorgen.
S61:Freisetzung in die Umwelt vermeiden. Besondere Anweisungen einholen/Sicherheitsdatenblatt zu Rate ziehen.
Beschreibung
Chlorisondamine is an antagonist of nicotinic acetylcholine receptors (nAChRs; IC
50 = 1.8 μM in rat striatal synaptosomes) and a ganglion blocker. It decreases dopamine release induced by nicotine (Item Nos.
16535 |
20887) in a dose-dependent manner in rat striatal synaptosomes at concentrations ranging from 0-100 μM. The effect of chlorisondamine is long-lasting, with a 10 mg/kg dose blocking nicotine-induced stimulant activity for at least five weeks. Chlorisondamine (5 μg, i.c.v.) prevents rats from acquiring a (–)-nicotine-induced conditioned taste aversion response, a model of the aversive effects of nicotine. It also inhibits autonomic ganglia, providing approximately 50% inhibition of the contractile response in feline superior cervical ganglion nictitating membrane preparations when administered at a dose of 50 mg/kg.
Verwenden
Chlorisondamine diiodide has been used:
- as a nicotinic receptor antagonist to test its effect on trinitrobenzene sulfonic acid (TNBS)-induced colitis
- as an irreversible nicotinic acetylcholine(nAChR) blocker to pre-treat brain samples to test its effect on cytochrome P450 2B (CYP2B) induction
- as a ganglionic blocker to test its effect on regulating corticosterone levels in rat with chronic stress
Biochem/physiol Actions
Chlorisondamine diiodide mediates ganglionic and central blockade.
CHLORISONDAMINE DIIODIDE Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
CHLORISONDAMINE DIIODIDE Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 29)Lieferanten
- Chlorisondamine (iodide)
- 4,5,6,7-tetrachloro-2-methyl-2-[2-(trimethylammonium)ethyl]isoindolinium diiodide
- CHLORCHLORISONDAMINE DIIODIDEISONDAMINE DIIODIDE
- 96750-66-2
- C14H20Cl4N22I
