Atosiban
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- CAS-Nr.
- 90779-69-4
- Englisch Name:
- Atosiban
- Synonyma:
- ATOSIBAN ACETATE;Antocin;RW-22164;Atosiban impurity;rwj22164;Atosiban;ORF22164;ORF 22164;ORF-22164;14-Deoxy-11
- CBNumber:
- CB7497854
- Summenformel:
- C43H67N11O12S2
- Molgewicht:
- 994.19
- MOL-Datei:
- 90779-69-4.mol
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Atosiban Eigenschaften
- Schmelzpunkt:
- >165oC (dec.)
- Siedepunkt:
- 1469.0±65.0 °C(Predicted)
- Dichte
- 1.254±0.06 g/cm3(Predicted)
- storage temp.
- -20°C
- L?slichkeit
- H2O: ≤100 mg/mL
- Aggregatzustand
- solid
- pka
- 12.81±0.70(Predicted)
- Farbe
- White to Off-White
- Wasserl?slichkeit
- Soluble to 50 mg/ml in water
- InChIKey
- VWXRQYYUEIYXCZ-XDSPZVSENA-N
- CAS Datenbank
- 90779-69-4(CAS DataBase Reference)
Atosiban Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Atosiban was introduced in the UK as an injectable inhibitor of preterm labor, a major
cause of infant morbidity and mortality. This peptidic oxytocin analog is an antagonist of
the vasopressin V
1a receptor and of the oxytocin receptor which is found in dramatically
increased concentration in the uterine myometrium of pregnant women near term. It
competitively inhibited contractions in the pregnant guinea pig uterus induced by oxytocin
and vasopressin. In a multicenter, double-blind, placebo-controlled trial, treatment with
atosiban caused pregnancy prolongation for up to 7 days in women with more than 28
weeks of gestation. In a comparative clinical trial, atosiban showed a comparable tocolytic
action (uterine relaxant) to ritodrine but the former was significantly better tolerated,
especially with regards to maternal cardiovascular side effects. In healthy volunteers,
plasma levels of atosiban decreased bi-exponentially with an initial and a terminal half-life of 21 min and 1.7h respectively.
Verwenden
Atosiban is an oxytocin receptor blocking agent in the treatment of experimental endometriosis and was shown exhibit significant therapeutic efficiency.
Indications
Atosiban is an analogue of oxytocin that is modified at
positions 1, 2, 4, and 8. It is a competitive inhibitor of
oxytocin binding. Early studies have demonstrated that
this drug does decrease and stop uterine contractions.
Atosiban is not available for use in the United States.
Anticancer Research
The antitumor effects of the essential oil of O. falcata were tested in transplantedmurine H22 solid tumors in vivo. Growth inhibition in H22 solid tumors was moderate(Yang et al. 2013).
Atosiban Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Atosiban Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 427)Lieferanten
90779-69-4()Verwandte Suche:
- 1-deamino-2d-tyr-(oet)-4-thr-8-orn-oxytocin
- oxytocin,1-(3-mercaptopropanoicacid)-2-(o-ethyl-d-tyrosine)-4-l-threonine-8-l
- rwj22164
- 1-(3-Mercaptopropionic acid)-2-(3-(p-ethoxyphenyl)-D-alanine)-4-L-thre onine-8-L-ornithineoxytocin
- [Mpr-D-Tyr(OEt)-Ile-Thr-Asn-Cys]-Pro-Orn-Gly-NH2
- (2S)-N-[(1S)-4-Amino-1-(carbamoylmethylcarbamoyl)butyl]-1-[(4S,7S,13S,16R)-13-[(2S)-butan-2-yl]-7-(carbamoylmethyl)-16-[(4-ethoxyphenyl)methyl]-10-(1-hydroxyethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]pyrrolidine-2-carboxamide
- 1-(3-Mercaptopropanoic acid)-2-(O-ethyl-D-tyrosine)-4-L-threonine-8-L-ornithineoxytocin
- 1-Deamino-2-D-Tyr-(O-ethyl)-4-Thr-8-ornoxytocin
- Atosiban
- Human Atosiban
- 1-Deamino-2-D-Tyr-(O-ethyl)-4-Thr-8-ornoxytocin, Tractocile, 1-(3-Mercaptopropanoic acid)-2-(O-ethyl-D-tyrosine)-4-L-threonine-8-L-ornithineoxytocin
- Atosiban,1-(3-Mercaptopropanoic acid)-2-(O-ethyl-D-tyrosine)-4-L-threonine-8-L-ornithineoxytocin, 1-Deamino-2-D-Tyr-(O-ethyl)-4-Thr-8-ornoxytocin, Tractocile
- Atosiban, RWJ 22164
- Oxytropis Falcata
- AtosibanAcetate(Tractocile)
- 3-Mercaptopropionyl-D-Tyr(Et)-Ile-Thr-Asn-Cys-Pro-Orn-Gly-NH2 (Disulfide bond)
- Atosiban impurity 1
- Atosiban, >=98%
- (Deamino-Cys1,D-Tyr(Et)2,Thr4,Orn8)-Oxytocin, Atosiban
- 1-({(4r,7s,13s,16r)-7-(2-amino-2-oxoethyl)-13-[(2s)-butan-2-yl]-16-(4-ethoxybenzyl)-10-[(1r)-1-hydroxyethyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosan-4-yl}carbonyl)-l-prolyl-l-ornithylglycinamide
- Glycinamide, O-ethyl-N-(3-mercapto-1-oxopropyl)-D-tyrosyl-L-isoleucyl-L-threonyl-L-asparaginyl-L-cysteinyl-L-prolyl-L-ornithyl-, cyclic (1→5)-disulfide
- Atosiban Impurity 41
- Atosiban USP/EP/BP
- Atosiban
DISCONTINUED PLEASE SEE A791890
- Atosiban acetate salt
- (S)-N-((S)-5-Amino-1-((2-amino-2-oxoethyl)amino)-1-oxopentan-2-yl)-1-((4R,7S,10S,13S,16R)-7-(2-amino-2-oxoethyl)-13-((S)-sec-butyl)-16-(4-ethoxybenzyl)-10-((R)-1-hydroxyethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosane-4-carbonyl)pyrrolidine-2-carboxamide
- (S)-N-((S)-5-Amino-1-((2-amino-2-oxoethyl)amino)-1-oxopentan-2-yl)-1-((4R,7S,10S,13S,16R)-7-(2-amino-2-oxoethyl)-13-((S)-sec-butyl)-16-(4-ethoxybenzyl)-10-((R)-1-hydroxyethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosane-4-carbonyl)p
- AtosibanQ: What is
Atosiban Q: What is the CAS Number of
Atosiban Q: What is the storage condition of
Atosiban Q: What are the applications of
Atosiban
- Atosiban Acetate(net)
- 12-didehydroandrographolide
- 14-Deoxy-11
- RW-22164;RWJ-22164
- Atosiban Impurtiy
- atosiban price
- (Deamino-Cys1,D-Tyr(Et)2,Thr4,Orn8)-Oxytocin acetate salt
- (Deamino-Cys?,D-Tyr(Et)?,Thr?,Orn?)-Oxytocin acetate salt
- ORF 22164
- ORF22164
- ORF-22164
- Tamoxifen Nolvadex 20mg Tablets
- (2S)-N-((S)-5-amino-1-((2-amino-2-oxoethyl)amino)-1-oxopentan-2-yl)-1-((4R,7S,10S,16R)-7-(2-amino-2-oxoethyl)-13-((S)-sec-butyl)-16-(4-ethoxybenzyl)-10-((R)-1-hydroxyethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosane-4-carbonyl)pyrrolidine-2-carboxamide
- Des-Pro Atosiban
- Antocin
- Atosiban impurity
- ATOSIBAN ACETATE
- RW-22164
- 90779-69-4
- 130756-54-2
- C45H71N11O14S2
- C43H67N11O12S2
- hormones
- Peptide
- 90779-69-4
- API
