Carbazamidinmonohydrochlorid
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- CAS-Nr.
- 1937-19-5
- Bezeichnung:
- Carbazamidinmonohydrochlorid
- Englisch Name:
- Aminoguanidine hydrochloride
- Synonyma:
- Aminoguanidine HCL;2-aminoguanidine hydrochloride;GUANYLHYDRAZINEHCL;AMINOGUANIDINE SALT;Aminoguanidine salts;CP-12009-18 tartrate;amino-guanidinhydrochloride;Aminoguanidine hydrochoride;Aminoguanadine hydrochloride;AMINOGUANIDINE HYDROCHLORIDE
- CBNumber:
- CB7497900
- Summenformel:
- CH7ClN4
- Molgewicht:
- 110.54608
- MOL-Datei:
- 1937-19-5.mol
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Carbazamidinmonohydrochlorid Eigenschaften
- Schmelzpunkt:
- 162-166 °C(lit.)
- Dampfdruck
- 0Pa at 25℃
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- L?slichkeit
- Completely soluble in water
- Aggregatzustand
- Crystals
- Farbe
- White to off-white
- Wasserl?slichkeit
- 506.7g/L at 20℃
- Merck
- 13,440
- BRN
- 3909606
- Kosmetik-Inhaltsstoffe Funktionen
- SKIN CONDITIONING
- InChI
- InChI=1S/CH6N4.ClH/c2-1(3)5-4;/h4H2,(H4,2,3,5);1H
- InChIKey
- UBDZFAGVPPMTIT-UHFFFAOYSA-N
- SMILES
- N(N)C(=N)N.[H]Cl
- LogP
- -3.55 at 20℃
- CAS Datenbank
- 1937-19-5(CAS DataBase Reference)
- EPA chemische Informationen
- Hydrazinecarboximidamide, monohydrochloride (1937-19-5)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Kennzeichnung gef?hrlicher |
Xi |
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| R-S?tze: |
36/37/38 |
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| S-S?tze: |
26-36 |
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| WGK Germany |
3 |
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| RTECS-Nr. |
ME8430000 |
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| F |
10-21 |
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| TSCA |
TSCA listed |
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| HS Code |
29280000 |
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| Speicherklasse |
13 - Non Combustible Solids |
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| Hazard Classifications |
Aquatic Chronic 2
Skin Sens. 1B |
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| Bildanzeige (GHS) |
 
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| Alarmwort |
Warnung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H317 |
Kann allergische Hautreaktionen verursachen. |
Sensibilisierung der Haut |
Kategorie 1A |
Warnung |
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P261, P272, P280, P302+P352,P333+P313, P321, P363, P501 |
| H411 |
Giftig für Wasserorganismen, mit langfristiger Wirkung. |
Langfristig (chronisch) gew?ssergef?hrdend |
Kategorie 2 |
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| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P272 |
Kontaminierte Arbeitskleidung nicht au?erhalb des Arbeitsplatzes tragen. |
| P273 |
Freisetzung in die Umwelt vermeiden. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P302+P352 |
BEI BERüHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckm??ig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen. |
| P333+P313 |
Bei Hautreizung oder -ausschlag: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen. |
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Carbazamidinmonohydrochlorid Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-S?tze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
Aminoguanidine is equipotent to L-
NMMA and L-NNA as an inhibitor of iNOS. The IC50 values for inhibition of mouse iNOS and rat nNOS are 5.4 and 160 μM, respectively. Aminoguanidine also inhibits induction of iNOS protein expression by endotoxin in rat macrophages. Aminoguanidine Hydrochloride is used in the synthetic preparation of
highly selective and potent G-protein-coupled receptor kinase 2 (GRK2)
inhibitor for potential treatment of heart failure.
Chemische Eigenschaften
white to off-white crystals
Verwenden
Aminoguanidine hydrochloride may be employed as nitric oxide synthase (NOS) inhibitor to investigate its effect on the reduction of alveolar bone loss in ligature induced periodontitis in rats. It may be used in the synthesis of 5-guanylhydrazone derivatives, having antibacterial activity against antibacterial activity against both Escherichia coli and Staphylococcus aureus.
Biologische Funktion
It is reported that aminoguanidine hydrochloride has two important biological effects. Firstly, it is effective for the prevention of formation of advanced glycation endproducts (AGEs) associated with pathogenesis of secondary complications to diabetes and with cardiovascular changes in aging. Aminoguanidine hydrochloride reacts rapidly with in vivo glycation α,β-dicarbonyl products such as methylglyoxal, glyoxal, and 3-deoxyglucosone to prevent the formation of AGEs.
Secondly, it inhibits of the individual isoforms of nitric oxide synthase (iNOS) which is one of three key enzymes generating nitric oxide (NO) from L-arginine. iNOS-derived nitric oxide plays an important role in numerous physiological (e.g. blood pressure regulation) and pathophysiological (e.g. inflammation) conditions.
Allgemeine Beschreibung
Aminoguanidine hydrochloride has been reported in a study as inhibitor of animal nitric oxide (NO)-synthase. Crystal structure of aminoguanidine hydrochloride has been investigated by Fourier and least squares method. Its crystals were monoclinic and the guanidine part of the aminoguanidinium ion is planar.
Carbazamidinmonohydrochlorid Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Carbazamidinmonohydrochlorid Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 310)Lieferanten
1937-19-5(Carbazamidinmonohydrochlorid)Verwandte Suche:
- amino-guanidinhydrochloride
- hydrazinecarboximidamidehydrochloride
- carbazamidine monohydrochloride
- AMINOGUANIDINE HYDROCHLORIDE, 98+%
- AMINOGUANIDINE SALT
- GUANYLHYDRAZINEHCL
- GUANIDINE,AMINO-,MONOHYDROCHLORIDE
- Aminoguanidine hydrochoride
- 1-Aminoguanidine·hydrochloride
- Aminoguanidine salts
- D015 AMinoguanidine hydrochloride
- AMinoguanidine hydrochloride, 98% 25GR
- AMinoguanidine Hydrochloride, 98.0%(T)
- Aminoguanidine monohydrochloride
- Hydrazinecarboximidamide hydrochlorideHydrochloride
- Aminoguanadine hydrochloride 98%
- Metformin Impurity 15(Aminoguanidine hydrochloride)
- Aminoguanadine hydrochloride
- Aminoguanidine hydrochloride, 98%, a diamine oxidase and NO synthase inhibitor
- AminoguanidineHydrochloride>
- CP-12009-18 tartrate
- AMINOGUANIDINE HYDROCHLORIDE ISO 9001：2015 REACH
- Aminoguanidine Hydrochloride (AGH)
- TIANFU-CHEM - AMINOGUANIDINE HYDROCHLORIDE
- Aminoguanidine Hydrochloride CAS NO.1937-19-5
- AMINOGUANIDINE HYDROCHLORIDE
- Nitric oxide synthases,GER 11,GER-11,NOS,Aminoguanidine hydrochloride,Aminoguanidinium,NO Synthase,inhibit,GER11,Inhibitor,Aminoguanidine
- Aminoguanidine hydrochloride, NOS inhibitor
- Aminoguanidine hydrochloride, 10 mM in DMSO
- 2-aminoguanidine hydrochloride
- Aminoguanidine HCL
- 1937-19-5
- 1973-19-5
- NH2NHCNHNH2HCl
- CH7ClN4
- CH6N4HClH2NNHCNHNH2HCl
- CH6N4ClH
- Signalling
- TUSACAPINE
- Nitric Oxide
- Pharmaceutical Intermediates
