5-Chlor-o-toluidin Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R22:Gesundheitssch?dlich beim Verschlucken.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R40:Verdacht auf krebserzeugende Wirkung.
R45:Kann Krebs erzeugen.
R23/24/25:Giftig beim Einatmen, Verschlucken und Berührung mit der Haut.
S-S?tze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn m?glich, dieses Etikett vorzeigen).
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S53:Exposition vermeiden - vor Gebrauch besondere Anweisungen einholen.
Chemische Eigenschaften
clear yellow to light brown liquid after melting
Verwenden
5-Chloro-2-toluidine, is a versatile building block used for the synthesis of various pharmaceutical and biologically active compounds including inhibitors. It is a carcinogenic monocyclic amine. The compound is used in synthesizing dyes.
m?gliche Exposition
Most of the isomers are used in dyestuff manufacture. The 3-chloro-para isomer is used to kill
birds. It is marketed as pelleted bait for control of bird
populations.
Carcinogenicity
A bioassay for the possible carcinogenicity of 5-chloro-otoluidine
was conducted using Fischer 344 rats and B6C3F1
mice. Groups of 50 male and 50 female rats and mice were
given 5-chloro-o-toluidine in the diet at 2500 or 5000 ppm for
rats and 2000 or 4000 ppm for mice. The compound was
administered for 78 weeks to both rats and mice, followed by
an observation period of up to 26 weeks for rats and 13 weeks
for mice. Under the conditions of this bioassay, 5-chloro-otoluidine
was carcinogenic to the mice, inducing hemangiosarcomas
and hepatocellular carcinomas in both males and
females. There was no conclusive evidence of the carcinogenicity
of the compound in the rats.
Versand/Shipping
UN2239 Chlorotoluidines, solid, Hazard Class:
6.1; Labels: 6.1-Poisonous materials. UN3429
Chlorotoluidines, liquid, Hazard Class: 6.1; Labels: 6.1-
Poisonous materials
Inkompatibilit?ten
Incompatible with oxidizers, strong
acids; chloroformates, and acid anhydrides, isocyanates,
aldehydes forming fire and explosive hazards.
Einzelnachweise
[1] Saim Topu. “Synthesis, characterization and antioxidant activities of some novel oxime derivatives.” Pharmacy Pharmacology International Journal 25 1 (2021).
5-Chlor-o-toluidin Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
