4-Acetyl-piperidine-1-carboxylic acid tert-butyl ester
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- CAS-Nr.
- 206989-61-9
- Englisch Name:
- 4-Acetyl-piperidine-1-carboxylic acid tert-butyl ester
- Synonyma:
- tert-Butyl 4-acetylpiperidine-1-carboxylate;N-Boc-4-acetylpiperidine;1-Boc-4-acetyL;N-Boc-4-Acetypiperidine;Zanubrutinib Impurity 6;Zanubrutinib impurity-22;1-BOC-4-ACETYL-PIPERIDINE;-N-Boc-4-Acetylpiperidine;1-N-Boc-4-Acetylpiperidine;1-BOC-ESTER4-ACETYL-PIPERIDINE
- CBNumber:
- CB7704363
- Summenformel:
- C12H21NO3
- Molgewicht:
- 227.3
- MOL-Datei:
- 206989-61-9.mol
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4-Acetyl-piperidine-1-carboxylic acid tert-butyl ester Eigenschaften
- Siedepunkt:
- 312.4±35.0 °C(Predicted)
- Dichte
- 1.052±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- pka
- -2.23±0.40(Predicted)
- Aggregatzustand
- solid
- Aussehen
- Colorless to off-white Liquid
- InChI
- InChI=1S/C12H21NO3/c1-9(14)10-5-7-13(8-6-10)11(15)16-12(2,3)4/h10H,5-8H2,1-4H3
- InChIKey
- HNVBBNZWMSTMAZ-UHFFFAOYSA-N
- SMILES
- N1(C(OC(C)(C)C)=O)CCC(C(C)=O)CC1
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Kennzeichnung gef?hrlicher |
T |
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| R-S?tze: |
25 |
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| S-S?tze: |
45 |
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| RIDADR |
UN 2811 6.1 / PGIII |
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| HazardClass |
IRRITANT |
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| HS Code |
2933399990 |
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| Speicherklasse |
6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects |
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| Hazard Classifications |
Acute Tox. 3 Oral |
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| Bildanzeige (GHS) |
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| Alarmwort |
Achtung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H301 |
Giftig bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 3 |
Achtung |
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P264, P270, P301+P310, P321, P330,P405, P501 |
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| Sicherheit |
| P301+P310 |
BEI VERSCHLUCKEN: Sofort GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen. |
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4-Acetyl-piperidine-1-carboxylic acid tert-butyl ester Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
tert-Butyl 4-Acetylpiperidine-1-carboxylate is a useful research chemical.
Synthese
Tert-butyl-4-(methoxy(methyl)carbamoyl)piperidine-1-carboxylate (2.29 g, 8.32 mmol) was dissolved in 30 ml of tetrahydrofuran (THF), and the resulting solution was cooled to -78 °C. To the solution, methylmagnesium bromide (3.0 M) (7.73 ml, 10.82 mmol) was slowly added, and the solution was stirred at 0 °C for 1 hr. After the reaction was completed with a 2 N hydrochloric acid aqueous solution, 6 N sodium hydroxide solution was added to adjust the pH to 10. Then the solution was extracted with dichloromethane. The organic layer was treated with magnesium sulfate (MgSO4) and filtered, and the solution was concentrated. The resulting residue was isolated and purified by silica gel column chromatography (dichloromethane/methanol = 10/1) to give 4-Acetyl-piperidine-1-carboxylic acid tert-butyl ester (6.36 g, 94.0 percent).
4-Acetyl-piperidine-1-carboxylic acid tert-butyl ester Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
4-Acetyl-piperidine-1-carboxylic acid tert-butyl ester Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 229)Lieferanten
206989-61-9()Verwandte Suche:
- 4-ACETYL-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
- 1-N-Boc-4-Acetylpiperidine
- 1-tert-Butoxycarbonyl-4-acetylpiperidine
- 1-Piperidinecarboxylic acid, 4-acetyl-, 1,1-dimethylethyl ester
- 1-BOC-4-ACETYL-PIPERIDINE
- N-Boc-4-Acetypiperidine
- 1-BOC-ESTER4-ACETYL-PIPERIDINE
- 4-acetyl-piperidine-1-carboxylic acid Mono t-butyl ester
- 4-acetyl-1-piperidinecarboxylic acid tert-butyl ester
- tert-butyl 4-ethanoylpiperidine-1-carboxylate
- 4-acetyl-1-(t-butoxycarbonyl)piperidine
- 1-Boc-4-acetyL
- Zanubrutinib Related Compound 4
- Zanubrutinib Impurity 6
- -N-Boc-4-Acetylpiperidine
- 7-(1-benzoylpiperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide
- Zanubrutinib benzoyl amide impurity
- Zanubrutinib impurity-22
- tert-Butyl 4-acetylpiperidine-1-carboxylate
- 1-(tert-Butoxycarbonyl)piperidin-4-yl methyl ketone
- N-Boc-4-acetylpiperidine
- tert-Butyl 4-acetylpiperidine-1-carboxylate
- 206989-61-9
- 206979-61-9
- C12H20NO4
