Natrium-[(2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)methylamino]methansulfonat
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- CAS-Nr.
- 68-89-3
- Bezeichnung:
- Natrium-[(2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)methylamino]methansulfonat
- Englisch Name:
- Metamizole sodium
- Synonyma:
- METAMIZOLE;DIPYRONE;METAMIZOL SODIUM;novaminsulfon;DIPYRONE SODIUM;SODIUM DIPYRONE;novaminsulfone;sulpyrin;Annaijin;metamizolum
- CBNumber:
- CB7741339
- Summenformel:
- C13H16N3NaO4S
- Molgewicht:
- 333.34
- MOL-Datei:
- 68-89-3.mol
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Natrium-[(2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)methylamino]methansulfonat Eigenschaften
- Schmelzpunkt:
- 227 °C
- Dichte
- 1.388 g/cm3
- storage temp.
- Inert atmosphere,Room Temperature
- L?slichkeit
- DMSO (Slightly), Methanol (Slightly), Water (Slightly)
- Aggregatzustand
- Solid
- Farbe
- Minute crystals
- Stabilit?t:
- Stable. Incompatible with strong oxidizing agents.
- InChI
- InChI=1S/C13H17N3O4S.Na/c1-10-12(14(2)9-21(18,19)20)13(17)16(15(10)3)11-7-5-4-6-8-11;/h4-8H,9H2,1-3H3,(H,18,19,20);/q;+1/p-1
- InChIKey
- DJGAAPFSPWAYTJ-UHFFFAOYSA-M
- SMILES
- [Na+].C(N(C1=C(C)N(C)N(C2=CC=CC=C2)C1=O)C)S([O-])(=O)=O
- CAS Datenbank
- 68-89-3(CAS DataBase Reference)
- NIST chemische Informationen
- Dipyrone(68-89-3)
- EPA chemische Informationen
- Methanesulfonic acid, 1-[(2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)methylamino]-, sodium salt (1:1) (68-89-3)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Kennzeichnung gef?hrlicher |
Xn |
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| R-S?tze: |
42/43 |
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| S-S?tze: |
36 |
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| WGK Germany |
2 |
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| RTECS-Nr. |
PB1300000 |
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| HS Code |
29331920 |
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| Toxizit?t |
LD50 orl-rat: 3 g/kg ARZNAD 21,719,71 |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
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P264, P270, P301+P312, P330, P501 |
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| Sicherheit |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P270 |
Bei Gebrauch nicht essen, trinken oder rauchen. |
| P501 |
Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen. |
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Natrium-[(2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)methylamino]methansulfonat Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R42/43:Sensibilisierung durch Einatmen und Hautkontakt m?glich.
S-S?tze Betriebsanweisung:
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Chemische Eigenschaften
solid
Verwenden
A non-steroidal anti-inflammatory drug that, when coadministered with morphine, potentiates its antinociceptive action and delays the development of tolerance. Dipyrone is a relatively selective inhibitor of cyclooxygenase-3 (COX-3), with lower activity against COX-1 and no activity against COX-2. Blocks PGE2-induced hyperalgesia in several models.
Definition
ChEBI: An organic sodium salt of antipyrine substituted at C-4 by a methyl(sulfonatomethyl)amino group, commonly used as a powerful analgesic and antipyretic.
Weltgesundheitsorganisation (WHO)
Metamizole sodium, a pyrazolone derivative with analgesic,
antipyretic and antinflammatory activity, was introduced in 1921 and has since been
widely available in over-the-counter products. By the early 1970s its use had been
associated, as with some other pyrazolones, with serious and sometimes fatal adverse
reactions, notably cases of blood dyscrasias including agranulocytosis, which led to
its withdrawal by some regulatory authorities. Although preparations of
metamirole sodium are prohibited in certain countries, they remain widely available in
others and, in some cases, in over-the-counter products.
Sicherheitsprofil
Poison by subcutaneous route. Moderately toxic by several other routes. An experimental teratogen. Other experimental reproductive effects. Human mutation data reported. Questionable carcinogen with experimental neoplastigenic data. See also SULFONATES. When heated to decomposition it emits very toxic fumes of NOx,, Na2O, and SOx,.
Natrium-[(2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)methylamino]methansulfonat Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Natrium-[(2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)methylamino]methansulfonat Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 318)Lieferanten
68-89-3(Natrium-[(2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)methylamino]methansulfonat)Verwandte Suche:
- nevralgina
- noramidopyrinemethanesulfonatesodium
- noramidopyrinium-methanesulphatenatrium
- noraminopyrinemethanesulfonatesodium
- optalgin
- paralgin
- phenyldimethylpyrazolonmethylaminomethanesodiumsulfonate
- pyralgin
- pyretin
- pyrojec
- sodium1-phenyl-2,3-dimethyl-4-methylaminopyrazolon-n-methanesulfonate
- sodium1-phenyl-2,3-dimethyl-5-pyrazolone-4-methylaminomethanesulfonate
- sodium4-methylamino-1,5-dimethyl-2-phenyl-3-pyrazolone4-methanesulfonate
- sodiummethylaminoantipyrinemethanesulfonate
- sodiumnoramidopyrinemethanesulfonate
- sodiumphenyldimethylpyrazolon-methylamino-methanesulfonate
- sodium [(2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1h-pyrazol-4-yl)methylamino]methanesulfonate
- Sodium [(2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)methylamino]methanesulphonate
- Alangin
- Analgin(metamizole)
- Analgin/MetamizoleSodium
- Dipyrone(MetamizoleSodium
- BENZALAGEN
- LABOTEST-BB LT00771955
- metamizole sodium
- Methanesulfonic acid, (2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)methylamino-, sodium salt
- [(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-N-methylamino] methanesulphonate
- Dipyrone Hcl / Analgin
- NoramidopyrineMethanesulfonatSodium
- N-(2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)-N-methylamino methanesulfoxylote sodium salt
- Analgin sodium
- N-Methyl-N-(2,3-dihydro-1,5-dimethyl-2-phenyl-3-oxo-1H-pyrazol-4-yl)aminomethanesulfonic acid sodium
- NSC-73205
- 1-[(2,3-Dihydro-1,5-diMethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)MethylaMino]Methanesulfonic Acid SodiuM Salt
- Algopyrin
- Anador
- Andolor
- ARPF
- Gifaril
- Lisador
- Metilon
- Sulpin
- analgin API
- METAMIZOLE SODIUM MONOHYDRATE PH EUR
- 1-phenyl-2,3-dimethyl-4-methylamino-5-pyrazolon-n-methanesulfonsaeurennatriu
- 1-phenyl-2,3-dimethyl-5-pyrazolone-4-methylaminomethanesulfonatesodium
- 1-phenyl-2,3-dimethylpyrazolone-(5)-4-methylaminomethanesulfonicacidsodium
- 4-methylamino-1,5-dimethyl-2-phenyl-3-pyrazolonesodiummethanesulfonate
- 4-sodiummethanesulfonatemethylamine-antipyrine
- alginodia
- algocalmin
- methylaminoantipyrinesodiummethanesulfonate
- methylaminophenyldimethylpyrazolonemethanesulfonatesodium
- methylmelubrin
- methylmelubrine
- narone
- neomelurbrin
- (antipyrinylmethylamino)methanesulfonicacidsodiumsalt
