5-Thia-1-azabicyclo[4.2.0]oct-2-en-2-carbonsure, 7-[[(2-Amino-4-thiazolyl)(methoxyimino)acetyl]amino]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-, Hydrochlorid (2:1), [6R-[6α,7β(Z)]]-
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- CAS-Nr.
- 75738-58-8
- Bezeichnung:
- 5-Thia-1-azabicyclo[4.2.0]oct-2-en-2-carbonsure, 7-[[(2-Amino-4-thiazolyl)(methoxyimino)acetyl]amino]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-, Hydrochlorid (2:1), [6R-[6α,7β(Z)]]-
- Englisch Name:
- Cefmenoxime hydrochloride
- Synonyma:
- Tacef;Cemix;Cefmax;Bestron;Bestcall;Abbott 50192;CEFMENOXIME HCL;CefMenoxiMe SodiuM;SCE-1365(free acid);sce1365hydrochloride
- CBNumber:
- CB7763319
- Summenformel:
- C16H18ClN9O5S3
- Molgewicht:
- 548.01
- MOL-Datei:
- 75738-58-8.mol
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5-Thia-1-azabicyclo[4.2.0]oct-2-en-2-carbonsure, 7-[[(2-Amino-4-thiazolyl)(methoxyimino)acetyl]amino]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-, Hydrochlorid (2:1), [6R-[6α,7β(Z)]]- Eigenschaften
- Schmelzpunkt:
- >175°C (dec.)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- L?slichkeit
- DMSO (Slightly, Heated), Methanol (Slightly)
- Aggregatzustand
- Solid
- Farbe
- Off-White to Pale Yellow
- InChIKey
- HZYJYGJIOCXOTH-AJVJENPNNA-N
- SMILES
- C(C1=C(CS[C@]2([H])[C@H](NC(=O)/C(/C3N=C(N)SC=3)=N\OC)C(=O)N12)CSC1=NN=NN1C)(=O)O.Cl |&1:5,7,r|
5-Thia-1-azabicyclo[4.2.0]oct-2-en-2-carbonsure, 7-[[(2-Amino-4-thiazolyl)(methoxyimino)acetyl]amino]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-, Hydrochlorid (2:1), [6R-[6α,7β(Z)]]- Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Cef menoxime hydrochloride is a third generation cephalosporin antibiotic.
Structurally, it possesses the (1-methyl-lH-tetrazol-5-yl)thiomethyl moiety in
the 3-position; like several other compounds containing this structural element
(moxalactam, cefoperazone, cefamandol), bleeding linked to vitamin K interaction
has been reported. Cefmenoxime has activity similar to cefotiuime, ceftizoxime
and moxalactam against E.coli, C. diversus, Klebsiella, P. Mirabilis, Salmonella,
Shigella, Neiseria spp., S. pyogenes, S. Pneumoniae, and g. influenzae. It is
relatively ineffective against Pseudomonas and Bacteroidea.
Verwenden
A third generation cephalosporin antibiotic with strong antimicrobial activities against Streptococcus pneumoniae, Haemophilus influenzae and Moraxella subgenus Branhamella catarrhalis that were 3 major aerobic bacteria from sinusitis.
Definition
ChEBI: The hemihydrochloride salt of cefmenoxime.
Allgemeine Beschreibung
Cefmenoxime was synthesized by Takeda Pharmaceutical Co. in 1978. It contains aminothiazole and methoxyimino groups in the 7-acyl position and a methyltetrazole group at the 3 position of the cephem nucleus. Cefmenoxime has a wide activity spectrum against gram-positive and gram-negative bacteria, including anaerobes, except Staphylococcus aureus. Cefmenoxime is a member of the so-called third-generation cephalosporins, a recently introduced class of clinically important antibiotics.
5-Thia-1-azabicyclo[4.2.0]oct-2-en-2-carbonsure, 7-[[(2-Amino-4-thiazolyl)(methoxyimino)acetyl]amino]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-, Hydrochlorid (2:1), [6R-[6α,7β(Z)]]- Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
5-Thia-1-azabicyclo[4.2.0]oct-2-en-2-carbonsure, 7-[[(2-Amino-4-thiazolyl)(methoxyimino)acetyl]amino]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-, Hydrochlorid (2:1), [6R-[6α,7β(Z)]]- Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 203)Lieferanten
75738-58-8(5-Thia-1-azabicyclo[4.2.0]oct-2-en-2-carbonsure, 7-[[(2-Amino-4-thiazolyl)(methoxyimino)acetyl]amino]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-, Hydrochlorid (2:1), [6R-[6α,7β(Z)]]-)Verwandte Suche:
- 8-[2-(2-amino-1,3-thiazol-4-yl)-2-methoxyimino-acetyl]amino-4-[(1-methyltetrazol-5-yl)sulfanylmethyl]-7-oxo-2-thia-6-azabicyclo[4.2.0]oct-4-ene-5-carboxylic acid hydrochloride (2:1)
- 7-[[(2-Amino-4-thiazolyl)(methoxyimino)acetyl]amino]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid hemihydrochloride
- 7beta-[2-(2-Aminothiazol-4-yl)-(Z)-2-(methoxyiminoacetamido)]-3-[(1-methyl-1H-tetrazol-5-yl)thiomethyl]ceph-3-em-4-carboxylic acid hemihydrochloride
- Bestcall
- Bestron
- Cemix
- SCE-1365(free acid)
- Tacef
- 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-, hydrochloride (2:1), [6R-[6α,7β(Z)]]-
- 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2Z)-(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-, hydrochloride (2:1), (6R,7R)-
- Abbott 50192
- Cefmax
- )(methoxyimino)acetyl)amino)-3-(((1-methyl-1h-tetrazol-5-yl)thio)methyl)-8-ox
- ab50912hemihydrochloride
- cefmenoximehemihydrochloride
- hydrochloride(2:1),(6r-(6-alpha,7-beta(z)))-o
- sce1365hydrochloride
- CEFMENOXIME HCL
- CEFMENOXIME HYDROCHLORIDE
- (6R)-7α-[[(2-Amino-4-thiazolyl)[(Z)-methoxyimino]acetyl]amino]-3-[[(1-methyl-1H-tetrazole-5-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]octa-2-ene-2-carboxylic acid·0.5hydrochloride
- 2Cefmenoxime·Hydrochloride
- Cefmenoxime Hydrochloride (350 mg)
- CefMenoxiMe SodiuM
- (6R,7R)-7-[[(2Z)-(2-AMino-4-thiazolyl)(MethoxyiMino)acetyl]aMino]-3-[[(1-Methyl-1H-tetrazol-5-yl)thio]Methyl]-8-oxo-5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid HeMihydrochloride
- CefMenoxiMe HCL Sterile (pure)
- Hydrochloride (syn-isomer)
- 7-[[2-(2-amino-4-thiazolyl)-2-methoxyimino-1-oxoethyl]amino]-3-[[(1-methyl-5-tetrazolyl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid hydrochloride
- CEFMENOXIME HEMIHYDROCHLORIDE;SCE-1365 HEMIHYDROCHLORIDE
- SCE-1365 hemihydrochloride
- (6R,7R)-7-((Z)-2-(2-aminothiazol-4-yl)-2-(methoxyimino)acetamido)-3-(((1-methyl-1H-tetrazol-5-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid hydrochloride(2:1)
- Cefmenoxime hydrochloride USP/EP/BP
- Cefmenoxime HCl (SCE-1365)
- Cefmenoxime Hydrochloride (1097771)
- Cefmenoxime HCL Powder USP Standard
- Cefmenoxime hydrochloride, 10 mM in DMSO
- 75738-58-8
- 75739-58-8
- 2C16H17N9O5S3HClC32H35ClN18O10S6
- C16H17N9O5S32HCl
- C16H17N9O5S312ClH
- C16H17N9O5S312HCl
- 2C16H17N9O5S3HCl
- C32H35ClN18O10S6
- CEFMAX
- Heterocycles
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Sulfur & Selenium Compounds
