FMOC-ARG(PDF)-OH
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- CAS-Nr.
- 154445-77-9
- Englisch Name:
- FMOC-ARG(PDF)-OH
- Synonyma:
- FMOC-ARG(PBF)-OH;FMOC-ARG(PBF);FMOC-L-ARG(PBF)-OH;Fomc-Arg(pbf)-OH;FMOC-L-ARG(PBF);-[(2,2,4,6,7-pentamethyl-2,3-dihydro-1-benzofuran-5-yl)sulfonyl]carbamimidamido}pentanoic acid;FMOC-(2,2,4,6,7-PENTAMETHYLDIHYDROBENZOFURAN-5-SULFONYL)-L-ARGININE;Fmoc-Arg(Pbf)-COOH;(S)-2-((((9H-Fluoren-9-yl)Methoxy)carbonyl)aMino)-5-(3-((2,2,4,6,7-pentaMethyl-2,3-dihydrobenzofuran-5-yl)sulfonyl)guanidino)pentanoic acid;Fmoc-Arq(Pbf)-OH
- CBNumber:
- CB7764987
- Summenformel:
- C34H40N4O7S
- Molgewicht:
- 648.77
- MOL-Datei:
- 154445-77-9.mol
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FMOC-ARG(PDF)-OH Eigenschaften
- Schmelzpunkt:
- 132°C
- alpha
- -5.5 º (c=1,DMF)
- Dichte
- 1.37±0.1 g/cm3(Predicted)
- storage temp.
- Store at -15°C to -25°C.
- L?slichkeit
- DMF (Sparingly), DMSO (Slightly), Methanol (Slightly)
- Aggregatzustand
- Solid
- pka
- 3.83±0.21(Predicted)
- Farbe
- White to Off-White
- Optische Rotation
- [α]/D -5.5±1.0°, c = 1 in DMF
- BRN
- 8302671
- Major Application
- peptide synthesis
- InChIKey
- YUMOVWGGELTYES-LJAQVGFWSA-N
- SMILES
- C(O)(=O)[C@H](CCCNC=NNS(C1=C(C)C(C)=C2OC(C)(C)CC2=C1C)(=O)=O)NC(OCC1C2=C(C=CC=C2)C2=C1C=CC=C2)=O
- CAS Datenbank
- 154445-77-9(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Kennzeichnung gef?hrlicher |
Xi |
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| R-S?tze: |
36/37/38 |
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| S-S?tze: |
26-36 |
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| WGK Germany |
1 |
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| HS Code |
2935 90 90 |
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| HazardClass |
IRRITANT |
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| Speicherklasse |
11 - Combustible Solids |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
|
P264, P270, P301+P312, P330, P501 |
| H312 |
Gesundheitssch?dlich bei Hautkontakt. |
Akute Toxizit?t dermal |
Kategorie 4 |
Warnung |
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P280,P302+P352, P312, P322, P363,P501 |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
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P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
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P264, P280, P305+P351+P338,P337+P313P |
| H332 |
Gesundheitssch?dlich bei Einatmen. |
Akute Toxizit?t inhalativ |
Kategorie 4 |
Warnung |
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P261, P271, P304+P340, P312 |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizit?t (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
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| Sicherheit |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P302+P352 |
BEI BERüHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckm??ig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
| P312 |
Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen. |
| P321 |
Besondere Behandlung |
| P322 |
Gezielte Ma?nahmen |
| P332+P313 |
Bei Hautreizung: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen. |
| P362 |
Kontaminierte Kleidung ausziehen und vor erneutem Tragen waschen. |
| P363 |
Kontaminierte Kleidung vor erneutem Tragen waschen. |
| P501 |
Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen. |
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FMOC-ARG(PDF)-OH Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-S?tze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Chemische Eigenschaften
white powde
Verwenden
Fmoc-L-Arg(Pbf)-OH is an amino acid building block used in peptide synthesis. With a growing peptide drug market the fast, reliable synthesis of peptides is of great importance.
Definition
Fmoc-Arg(Pbf)-OH is the standard derivative for the introduction of Arg in Fmoc SPPS. In the preparation of peptides containing both Arg and Trp, it is recommended that this derivative is used in conjunction with Fmoc-Trp(Boc)-OH. The Pbf side-chain protecting group is removed with TFA approximately 1-2 times faster than Pmc. TFA cleavage is best performed in the presence of a silane scavenger. The Pbf group of Fmoc-Arg(Pbf)-OH can be cleaved under moderate acid conditions.
Reaktivit?t anzeigen
The Pbf group of Fmoc-L-Arg(Pbf)-OH can be cleaved under moderate acid conditions. The amount of tryptophan alkylation is significantly reduced compared to other arginine side chain protecting groups, especially in the absence of scavengers. In one example reported in the literature, a peptide containing Arg(Pmc) was cleaved, and deprotected TFA resulted in 46% of the desired peptide.
Synthese
The synthesis method of Fmoc-L-Arg(Pbf)-OH: first esterifies the carboxyl group of arginine, then introduces a Boc group on the amino group to protect the amino group, introduces a Pbf group on the guanidine group, and removes the Boc group , saponification, and finally the introduction of the Fmoc group on the amino group.
FMOC-ARG(PDF)-OH Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
FMOC-ARG(PDF)-OH Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 560)Lieferanten
| Firmenname |
Telefon |
E-Mail |
Land |
Produktkatalog |
Edge Rate |
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Chengdu ZY Biochemical Technology Co., Ltd.
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+86-86-2888626688 +8618980008884
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xuehaiying@zybiochem.com |
China |
177 |
58 |
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Chemtour Biotech Co., Ltd
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+8617327281506
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market@chemtour.com |
China |
1521 |
58 |
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Chengdu Baishixing Science and Technology Industry Co.,Ltd
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+86-15008457246
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yuki@cd-bsx.com |
China |
53 |
58 |
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Sichuan HongRi Pharma-Tech Co.,Ltd
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+8618382028708
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ni@enlaibio.com |
China |
1103 |
58 |
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Hebei Chuanghai Biotechnology Co., Ltd
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+8615350571055
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Sibel@chuanghaibio.com |
China |
8738 |
58 |
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Hangzhou ICH Biofarm Co., Ltd
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+86-0571-28186870; +undefined8613073685410
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sales@ichemie.com |
China |
1006 |
58 |
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HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
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+86-15350851019; +8615350851019
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admin@86-ss.com |
China |
999 |
58 |
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Hefei Lbao Physical & Chemical Science Co.,Ltd
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+15184799099
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lbaochemicals@gmail.com |
China |
670 |
58 |
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Capot Chemical Co.,Ltd.
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+86-（0）57185586718 +86-13336195806
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sales@capot.com |
China |
29640 |
60 |
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Shanghai Daken Advanced Materials Co.,Ltd
|
+86-2158073036
|
info@dakenam.com |
China |
14014 |
58 |
154445-77-9()Verwandte Suche:
- na-fmoc-ng-(2,2,4,6,7-pentamethyl-*dihydrobenzofu
- FMOC-N-OMEGA-(2,2,4,6,7-PENTAMETHYLDIHYDROBENZOFURAN-5-SULFONYL)-L-ARGININE
- FMOC-NG-PBF-L-ARGININE
- FMOC-ARGININE(PBF)-OH
- FMOC-L-ARGININE(PBF)
- pentaMethyldihydrobenzofuran-5-sulfonyl)-L-arginine
- Nalpha-Fmoc-Nomega-Pbf-L-arginine
Fmoc-Arg(Pbf)-OH
- N^a-FMoc-N^w-(2,2,4,6,7-pentaMethyl-2,3-dihydrobenzo[b]furan-5-ylsulfonyl)-L-arginine, 98%
- Na-FMoc-Nw-Pbf-L-arginine
- N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-N-OMEGA-2,2,4,6,7-PENTAMETHYLDIHYDROBENZOFURAN-5-SULFONYL-L-ARGININE
- N-ALPHA-9-FLUORENYLMETHOXYCARBONYL-NG-2,2,4,6,7-PENTAMETHYLDIHYDROBENZOFURAN-5-SULFONYL-L-ARGININE
- N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-N'-2,2,4,6,7-PENTAMETHYLDIHYDROBENZOFURAN-5-SULFONYL-L-ARGININE
- N-ALPHA-FMOC-N'-2,2,4,6,7-PENTAMETHYLDIHYDROBENZOFURAN-5-SULFONYL-L-ARGININE
- N-ALPHA-FMOC-N-G-2,2,4,6,7-PENTAMETHYLDIHYDROBENZOFURAN-5-SULFONYL-L-ALPHARGININE
- N-ALPHA-FMOC-N-G-(2,2,4,6,7-PENTAMETHYLDIHYDROBENZOFURAN-5-SULFONYL)-L-ARGININE
- N-ALPHA-FMOC-N-OMEGA-PBF-L-ARGININE
- N-ALPHA-FMOC-N-OMEGA-(2,2,4,6,7-PENTAMETHYLDIHYDROBENZOFURAN-5-SULFONYL)-L-ARGININE
- N ALPHA-9-FLUORENYLMETHYLOXYCARBONYL-N OMEGA-2,2,4,6,7-PENTAMETHYLDIHYDROBENZOFURAN-5-SULFONYL-L-ARGININE
- Nα-FMoc-Nω-(2,2,4,6,7-pentaMethyldihydrobenzofuran-5-sulfonyl)-L-arginine
- L-Ornithine, N5-[[[(2,3-dihydro-2,2,4,6,7-pentamethyl-5-benzofuranyl)sulfonyl]amino]iminomethyl]-N2-[(9H-fluoren-9-ylmethoxy)carbonyl]-
- Nα-Fmoc-Nω-(2,2,4,6,7-pentamethyldihydro-benzofuran-5-sulfonyl)-L-arginine≥ 99.5% (HPLC, Chiral purity)
- Nalpha-Fmoc-Nomega-(2,2,4,6,7-pentamethyl-2,3-dihydrobenzo[b]furan-5-ylsulfonyl)-L-arginine
- FMoc-Arg(Pbf)-OH >=98.0% (HPLC)
- Nα-Fmoc-Nω-(2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl)-L-arginine
- Na-Fmoc-Ng-2,2,4,6,7-pentamethyl-dihydrobenzofuran-5-sulfonyl-L-arginine
- N-α-Fmoc-N-ω-2,2,4,6,7-pentamethyldihydro
- NA-FMOC-NG-(2,2,4,6,7-PENTAMETHYL-*DIHYD ROBENZOFURA
- Fmoc-Arq(Pbf)-OH
- NALPHA-9-Fluorenylmethoxycarbonyl-NOMEGA-(2,2,4,6,7-pentamethyldihydrobenzo
- N-alpha-(9-Fluorenylmethyloxycarbonyl)-N-2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl-L-arginine
- N-Fmoc-Ng-2,2,4,6,7-pentamethyldihydrobenzofuran-5- sulfonyl-D-Arginine
- FMOC-pentamethyldihydrobenzofuran-5-sulfonyl-L-arginine
- Nα-Fmoc-Nω-(2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl)-L-arginine, Nα-Fmoc-Nω-Pbf-L-arginine
- Nα-Fmoc-Nω-Pbf-L-arginine ,98%
- Fmoc-(2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl)-L-argin
- fmoc-(2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfon
- FMoc-Arg(Pbf)-OH N-α-FMoc-N-ω-2,2,4,6,7-pentaMethyldihydro
- Nalpha-[(9H-Fluoren-9-ylMethoxy)carbonyl]-NoMega-(2,2,4,6,7-pentaMethyldihydrobenzofuran-5-sulfonyl)-L-arginine
- Fmoc-Arg(Pbf) ,98%
- nα-fmoc-nω-(2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl)-l-arginine
- Nalpha-9-Fluorenylmethyloxycarbonyl-Nw-2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl-L-arginine
- L-ARGININE-N-FMOC, PBF (CHEMICAL PURITY 90-95%)
- FMOC-L-ARG(PBF)-OH(154445-77-9)
- Nα-[(9H-Fluoren-9-ylmethoxy)carbonyl]-Nω-(2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl)-L-arginine
- (9H-Fluoren-9-yl)MethOxy]Carbonyl Arg(Pbf)-OH
- N5-[[[(2,3-Dihydro-2,2,4,6,7-pentamethyl-5-benzofuranyl)sulfonyl]amino]iminomethyl]-N2-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-ornithine
- Nalpha-Fmoc-Nomega-(2,2,4,6,7-pentamethyl-2,3-dihydrobenzo[b]furan)-5-sulfonyl-L-arginine
- (2S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-5-{N'-[(2,2,4,6,7-pentamethyl-2,3-dihydro-1-benzofuran-5-yl)sulfonyl]carbamimidamido}pentanoic acid
- Nα-[(9H-Fluoren-9-ylmethoxy)carbonyl]-Nomega-(2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl)-L-arginine>
- FMOC-ARG(PBF)-OH 100 G
- FMOC-ARG(PBF)-OH 250 G
- FMOC-ARG(PBF)-OH 5 G
- (2S)-5-[[amino-[(2,2,4,6,7-pentamethyl-3H-1-benzofuran-5-yl)sulfonylamino]methylidene]amino]-2-(9H-fluoren-9-ylmethoxycarbonylamino)pentanoicaci
- FMOC-Arg(Pbf)-OH USP/EP/BP
- Nα-Fmoc-Nω-(2,2,4,6,7-pentamethyldihydro-benzofuran-5-sulfonyl)-L-arginine
- Fmoc PBF arginine / 154445-77-9
- (2S)-5-[[amino-[(2,2,4,6,7-pentamethyl-3H-1-benzofuran-5-yl)sulfonylamino]methylidene]amino]-2-(9H-fluoren-9-ylmethoxycarbonylamino)pentanoic acid
- Nα-Fmoc-Nω-Pbf-L-arginine
