Alanosine
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- CAS-Nr.
- 5854-93-3
- Englisch Name:
- Alanosine
- Synonyma:
- SDX 102;Alanosine;NSC 529469;NSC 153353;NSC-143647;L-Alanosine;Alanosine USP/EP/BP;Alanosine (SDX-102);L-Alanosine (NSC-153353;3-(Hydroxynitrosoamino)-L-alanine
- CBNumber:
- CB7875456
- Summenformel:
- C3H7N3O4
- Molgewicht:
- 149.11
- MOL-Datei:
- 5854-93-3.mol
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Alanosine Eigenschaften
- Schmelzpunkt:
- 1900C (dec.)
- alpha
- D +8°, -46°, -37.8° (in 1N HCl, 0.1N NaOH, water)
- Siedepunkt:
- 270.14°C (rough estimate)
- Dichte
- 1.6720 (rough estimate)
- Brechungsindex
- 1.4900 (estimate)
- storage temp.
- -20°C Freezer
- L?slichkeit
- Aqueous Acid, Aqueous Base
- pka
- 4.8(at 25℃)
- Aggregatzustand
- Solid
- Farbe
- Off-White to Pale Beige
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Toxizit?t |
LD50 in mice (mg/kg): 600 i.p.; 300 i.v. (Thiemann, Murthy) |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
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P264, P270, P301+P312, P330, P501 |
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| Sicherheit |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P270 |
Bei Gebrauch nicht essen, trinken oder rauchen. |
| P301+P312 |
BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen. |
| P330 |
Mund ausspülen. |
| P501 |
Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen. |
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Alanosine Chemische Eigenschaften,Einsatz,Produktion Methoden
Chemische Eigenschaften
Crystalline Powder
Verwenden
Antibiotic substance from the fermentation of Streptomyces alanosinicus. The first natural product found to have a N-nitrosohydroxylamino group on an aliphatic chain. An experimental insect reproduction inhibitor
Enzyminhibitor
This antibiotic and aspartate/asparagine analogue (FW = 149.11 g/mol; CAS 5854-93-3), also named L-2-amino-3-(N-hydroxy-N-nitrosoamino) propionic acid, isolated from fermentation broths of Streptomyces alanosinicus, inhibits adenylosuccinate synthetase, disrupting de novo synthesis of AMP in both malignant and normal cells. That alanosine inhibits the adenylosuccinate synthetase reaction, the first step in the conversion of IMP to AMP, is evidenced by the accumulation of IMP, but not adenylosuccinate, in treated cells. L-Alanosine’s action is potentiated in methylthioadenosine phosphorylase (MTAP) deficiency. Clinical use is limited by its toxicity. At a concentration as low as 2.7 μM, L-alanosine completely inhibits the incorporation of hypoxanthine into adenosine triphosphate by cultured Novikoff rat hepatoma cells. A related agent, L-alanosyl-5-aminoimidazole-4-carboxylic acid ribonucleotide (or alanosyl-AICOR) has been synthesized enzymatically using 4-(N-succino)- 5-aminoimidazole-4-carboxamide ribonucleotide (or SAICAR) synthetase in conjunction with 5-aminoimidazole-4-carboxylic acid ribonucleotide and alanosine. Alanosyl-AICOR is not a substrate of adenylosuccinate lyase from rat skeletal muscle, but it was an apparent competitive inhibitor in both reactions catalyzed by the enzyme.
Alanosine Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Alanosine Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 52)Lieferanten
5854-93-3()Verwandte Suche:
- 2-AMINO-3-(N-HYDROXY-N-NITROSAMINO)-PROPIONICACID
- L-2-Amino-3-(N-nitroso)hydroxylaminopropionic Acid
- NSC 153353
- NSC 529469
- SDX 102
- Alanosine
- (S)-2-Amino-3-[hydroxy(nitroso)amino]propionic acid
- NSC-143647
- 2-Amino-3-(hydroxynitrosamino)propionic acid, L-
- L-2-Amino-3-(hydroxynitrosamino)propionic acid
- L-Alanine, 3-(hydroxynitrosoamino)-
- Propionic acid, 2-amino-3-(hydroxynitrosamino)-, (L)-
- Propionic acid, 2-amino-3-(hydroxynitrosamino)-, L-
- 3-(Hydroxynitrosoamino)-L-alanine
- L-Alanosine
- Alanosine USP/EP/BP
- L-Alanosine (NSC-153353
- Alanosine (SDX-102)
- (S)-2-amino-3-(hydroxy(nitroso)amino)propanoic acid
- 5854-93-3
- Amino Acids 13C, 2H, 15N
- Amino Acids & Derivatives
- Chiral Reagents
- Inhibitors
- Intermediates & Fine Chemicals
- Pharmaceuticals
