(2S)-2,6-DIAMINO-N-[(1S)-1-METHYL-2-PHENYLETHYL]HEXANAMIDE DIMETHANESULFONATE
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- CAS-Nr.
- 608137-33-3
- Englisch Name:
- (2S)-2,6-DIAMINO-N-[(1S)-1-METHYL-2-PHENYLETHYL]HEXANAMIDE DIMETHANESULFONATE
- Synonyma:
- Lisdexamfetamine mesilate;Ldx;Lisdexamfetamine mesylate;Lisdexamfetamine dimesylate;Lisdexamphetamine-Dimesylate;Spd489;Spd 489;Nrp-104;Nrp 104;Lisdexamfetamine (mesylate) (CRM)
- CBNumber:
- CB81008991
- Summenformel:
- C16H29N3O4S
- Molgewicht:
- 359.49
- MOL-Datei:
- 608137-33-3.mol
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(2S)-2,6-DIAMINO-N-[(1S)-1-METHYL-2-PHENYLETHYL]HEXANAMIDE DIMETHANESULFONATE Eigenschaften
- Flammpunkt:
- 9℃
- storage temp.
- -20°C
- Aggregatzustand
- A neat solid
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
  
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| Alarmwort |
Achtung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H225 |
Flüssigkeit und Dampf leicht entzündbar. |
Entzündbare Flüssigkeiten |
Kategorie 2 |
Achtung |
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P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501 |
| H370 |
Sch?digt die Organe. |
Spezifische Zielorgan-Toxizit?t (einmalige Exposition) |
Kategorie 1 |
Achtung |
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P260, P264, P270, P307+P311, P321,P405, P501 |
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| Sicherheit |
| P210 |
Von Hitze, hei?en Oberfl?chen, Funken, offenen Flammen und anderen Zündquellenarten fernhalten. Nicht rauchen. |
| P260 |
Dampf/Aerosol/Nebel nicht einatmen. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P301+P310 |
BEI VERSCHLUCKEN: Sofort GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen. |
| P311 |
GIFTINFORMATIONSZENTRUM/Arzt anrufen. |
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(2S)-2,6-DIAMINO-N-[(1S)-1-METHYL-2-PHENYLETHYL]HEXANAMIDE DIMETHANESULFONATE Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
ADHD is a neurobehavioral disorder characterized by varying degrees of
inattention, hyperactivity, and impulsivity. ADHD is typically diagnosed in
childhood and affects 7–12% of the pediatric population in the United States with
the condition often enduring into adulthood.
While the precise mechanism of action of lisdexamfetamine
in treating ADHD is not known, amphetamines are believed to inhibit the
reuptake of the neurotransmitters dopamine and noradrenaline (norepinephrine),
thereby increasing their presynaptic availability and release into extraneuronal space. The prodrug is constructed by the condensation of D-amphetamine with the activated ester (N-hydroxysuccinimide) of bis-tert-butoxycarbonylprotected L-lysine. Lisdexamfetamine is ultimately generated by treatment with hydrochloric acid in dioxane.
The most common adverse events, comparable to other amphetamine formulations, were decreased appetite, insomnia, upper abdominal pain, and irritability. Lisdexamfetamine is contraindicated in patients with advanced arteriosclerosis, symptomatic cardiovascular disease, moderate-to-severe hypertension, hyperthyroidism, known hypersensitivity to the sympathomimetic amines, glaucoma, a predisposition to agitated states, and a history of drug abuse. In addition, the drug should not be administered during or within 14 days of treatment with monoamine oxidase inhibitors. It has also been noted that psychostimulants may exacerbate symptoms of pre-existing psychotic disorders, so caution and close observation are recommended in this patient population.
Verwenden
Treatment of atten tion deficit hyperactivity disorder (ADHD).
(2S)-2,6-DIAMINO-N-[(1S)-1-METHYL-2-PHENYLETHYL]HEXANAMIDE DIMETHANESULFONATE Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
(2S)-2,6-DIAMINO-N-[(1S)-1-METHYL-2-PHENYLETHYL]HEXANAMIDE DIMETHANESULFONATE Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 47)Lieferanten
- (2S)-2,6-DIAMINO-N-[(1S)-1-METHYL-2-PHENYLETHYL]HEXANAMIDE DIMETHANESULFONATE
- Nrp 104
- Nrp-104
- Spd 489
- Spd489
- Lisdexamfetamine dimesylate solution
- Lisdexamfetamine (mesylate) (exempt preparation)
- (2S)-2,6-diamino-N-[(2S)-1-phenylpropan-2-yl]hexanamide,methanesulfonic acid
- (2S)-2,6-DIAMINO-N-[(1S)-1-METHYL-2-PHENYLETHYL]HEXANAMIDE DIMETHANESULFONATE USP/EP/BP
- Lisdexamphetamine 13CD3 Dimesylate
- Lisdexamfetamine mesilate
- Lisdexamfetamine (mesylate) (CRM)
- Lisdexamphetamine Dimesylate (1mg/ml in Methanol)
- Lisdexamfetamine dimesylate
- Ldx
- Lisdexamfetamine mesylate
- Lisdexamphetamine-Dimesylate
- 608137-33-3
- C15H25N3O2CH4O3S
- C17H33N3O7S2
