Bilastine
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- CAS-Nr.
- 202189-78-4
- Englisch Name:
- Bilastine
- Synonyma:
- Bilastine;Bilastin;2-(4-(2-(4-(1-(2-ETHOXYETHYL)-1H-BENZO[D ]IMIDAZOL-2-YL) PIPERIDIN-1-YL)ETHY)PHEN YL)-2-METHYLPROPANOIC ACID;Bilaxten;2-(4-(2-(4-(1-(2-ethoxyethyl)-1H-benzo[d]imidazol-2-yl)piperidin-1-yl)ethyl)phenyl)-2-methylpropanoic acid;Bilatex;Bilasten;Bilestin;Bilastene;D6-Bilastine
- CBNumber:
- CB81011081
- Summenformel:
- C28H37N3O3
- Molgewicht:
- 463.62
- MOL-Datei:
- 202189-78-4.mol
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Bilastine Eigenschaften
- Schmelzpunkt:
- 202 °C
- Siedepunkt:
- 639.1±55.0 °C(Predicted)
- Dichte
- 1.16±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- Wasserl?slichkeit
- Insoluble in water
- L?slichkeit
- DMSO:49.3(Max Conc. mg/mL);106.34(Max Conc. mM)
- pka
- 4.40±0.10(Predicted)
- Aggregatzustand
- powder to crystal
- Farbe
- White to Light yellow
- Optische Rotation
- -0.2797°(C=0.7419g/100mI, CHCL3, 20°C, 589nm)
- InChI
- 1S/C28H37N3O3/c1-4-34-20-19-31-25-8-6-5-7-24(25)29-26(31)22-14-17-30(18-15-22)16-13-21-9-11-23(12-10-21)28(2,3)27(32)33/h5-12,22H,4,13-20H2,1-3H3,(H,32,33)
- InChIKey
- ACCMWZWAEFYUGZ-UHFFFAOYSA-N
- SMILES
- C(N1C2=CC=CC=C2N=C1C1CCN(CCC2C=CC(C(C)(C)C(=O)O)=CC=2)CC1)COCC
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| WGK Germany |
WGK 3 |
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| HS Code |
2933.39.4100 |
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| Speicherklasse |
11 - Combustible Solids |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
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P264, P270, P301+P312, P330, P501 |
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| Sicherheit |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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Bilastine Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Bilastine, a potent and selective histamine H1 receptor antagonist, was
approved in Europe in 2010 for the treatment of allergic rhinoconjunctivitis
(AR) and urticaria (hives or skin rash). The original synthesis of bilastine involves alkylation of 2-piperidinyl-1H-benzimidazole with a phenethyltosylate,
the para position of which is substituted with a dimethyloxazoline
moiety serving as a masked carboxylic acid group. Alkylation of the
benzimidazole nitrogen with 2-chloroethyl ethyl ether followed by
unmasking of the oxazoline moiety with sulfuric acid provided bilastine.
In two major clinical trials, bilastine was effective
at relieving allergic rhinitis as assessed by measuring the severity of nasal (obstruction, rhinorrhea, itching, sneezing) and nonnasal (ocular
itching, tearing, ocular redness, itching of ears, and/or palate) symptoms.
Verwenden
Bilastine is a novel, nonsedating H1-antihistamine developed for symptomatic treatment of allergic rhinitis and chronic idiopathic urticaria.
Clinical Use
Bilastine is a selective histamine H1 antagonist approved for the
treatment of allergic rhinoconjunctivitis and urticaria (hives). This drug, which has proven to be well tolerated in toxicology profiling,
46 was discovered by the Spainsh firm FAES Farma and was
approved by the European Union in 2010.
Bilastine Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Bilastine Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 340)Lieferanten
202189-78-4()Verwandte Suche:
- 4-[2-[4-[1-(2-Ethoxyethyl)-1H-benziMidazol-2-yl]-1-piperidinyl]ethyl]-α,α-diMethylbenzeneacetic Acid
- Benzeneacetic acid,4-[2-[4-[1-(2-ethoxyethyl)-1H-benziMidazol-2-yl]-1-piperidinyl]ethyl]-a,a-diMethyl-
- BENZENEACETIC ACID, 4-(2-(4-(1-(2-ETHOXYETHYL)-1H-BENZIMIDAZOL-2-YL)-1-PIPERIDINYL)ETHYL-ALPHA, ALPHA-DIMETHYL-
- 2-[4-[2-[4-[1-(2-ethoxyethyl)benzoimidazol-2-yl]-1-piperidyl]ethyl]phenyl]-2-methyl-propanoic acid
- 4-[2-[4-[1-(2-Ethoxyethyl)-1H-benzimidazol-2-yl]-1-piperidinyl]ethyl]-alpha,alpha-dimethylbenzeneacetic acid
- Bilasten
- 2-[4-[2-[4-[1-(2-ethoxyethyl)benzimidazol-2-yl]piperidin-1-yl]ethyl]phenyl]-2-methylpropanoic acid
- the impurity of Bilastine
- 2-[4-[2-[4-[1-(2-Ethoxyethyl)benzimidazol-2-yl]piperidin-1-yl]ethyl]phenyl]-2-methylproionic acid
- Bilatex
- Benzeneacetic acid, 4-[2-[4-[1-(2-ethoxyethyl)-1H-benzimidazol-2-yl]-1-piperidinyl]ethyl]-α,α-dimethyl-
- BENZENEACETIC ACID, 4-(2-(4-(1-(2-ETHOXYETHYL)-1H-BENZIMIDAZOL-2-YL)-1-PIPERIDINYL)ETHYL-ALPHA, ALPHA-DIMETHYL- USP/EP/BP
- 2-[4-[2-[4-[1-(2-Ethoxyethyl)benzimidazol-2-yl]piperidin-1-y...
- 2-(4-(2-(4-(1-(2-ethoxyethyl)-1H-benzo[d]imidazol-2-yl)piperidin-1-yl)ethyl)phenyl)-3-methylpropanoic acid
- BilastineQ: What is
Bilastine Q: What is the CAS Number of
Bilastine Q: What is the storage condition of
Bilastine Q: What are the applications of
Bilastine
- Bilastine D6Q: What is
Bilastine D6 Q: What is the CAS Number of
Bilastine D6 Q: What is the storage condition of
Bilastine D6 Q: What are the applications of
Bilastine D6
- Bilastine
- Bilaxten
- 2-(4-(2-(4-(1-(2-ETHOXYETHYL)-1H-BENZO[D ]IMIDAZOL-2-YL) PIPERIDIN-1-YL)ETHY)PHEN YL)-2-METHYLPROPANOIC ACID
- Bilastine (Form-I)
- 2-[4-[2-[4-[1-(2-ethoxyethyl)benzimidazol-2-yl]piperidin-1-yl]ethyl]phenyl]-2-methylpropanoicaci
- Bilastine In-House
- Bilastene
- Bilastine -IP/BP/
- Bilestin
- 4-[2-[4-[1-(2-Ethoxyethyl)-1H-benzimidazol-2-yl]-1-piperidinyl]ethyl]-a,a-dimethylbenzeneacetic acid
- D6-Bilastine
- 4-[2-[4-[1-(2-Ethoxyethyl)-1H-benzo[d]imidazol-2-yl]piperidin-1-yl]-ethyl]-alpha,alpha-dimethylphenyl-acetic acid
- 2-(4-(2-(4-(1-(2-ethoxyethyl)-1H-benzo[d]imidazol-2-yl)piperidin-1-yl)ethyl)phenyl)-2-methylpropanoic acid
- Bilastin
- 202189-78-4
- 202189-78-6
- C28H31D6N3O3
- Aromatics
- Heterocycles
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Isotope Labelled Compounds
- API
