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Quinupristin

Quinupristin Struktur
120138-50-3
CAS-Nr.
120138-50-3
Englisch Name:
Quinupristin
Synonyma:
RP 68888;RP 57669;Antibiotic RP 57669;Quinupristin Mesylate;Quinupristin(RP-57669);Quinupristin Discontinued;Quinupristin/dalfopristin,Quinupristin,antibiotic,Quinupristin-dalfopristin,streptogramin,Inhibitor,Bacterial,inhibit;4-[4-(DiMethylaMino)-N-Methyl-L-phenylalanine]-5-[(2S,5R)-5-[[[(3S)-1-azabicyclo[2.2.2]oct-3-yl]thio]Methyl]-4-oxo-2-piperidinecarboxylic acid]virginiaMycin S1;Virginiamycin S1, 4-[4-(dimethylamino)-N-methyl-L-phenylalanine]-5-[(2S,5R)-5-[[[(3S)-1-azabicyclo[2.2.2]oct-3-yl]thio]methyl]-4-oxo-2-piperidinecarboxylic acid]-
CBNumber:
CB81073487
Summenformel:
C53H67N9O10S
Molgewicht:
1022.23
MOL-Datei:
120138-50-3.mol

Quinupristin Eigenschaften

Schmelzpunkt:
~200°
L?slichkeit
DMF: Soluble
DMSO: Soluble
Ethanol: Soluble
Methanol: Soluble
Aggregatzustand
Solid
Farbe
White to off-white
Henry's Law Constant
4.9×1022 mol/(m3Pa) at 25℃, HSDB (2015)

Sicherheit

Giftige Stoffe Daten 120138-50-3(Hazardous Substances Data)

Quinupristin Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Quinupristin is a streptogramin antibiotic that blocks peptide bond formation and peptide extension in bacteria. Quinupristin is usually combined with another streptogramin antibiotic, dalfopristin , to produce quinupristin-dalfopristin complex , known commercially as Synercid. While both quinupristin and dalfopristin have bacteriostatic effects, they act synergistically to kill Gram-positive bacteria, as well as some Gram-negative and anaerobic bacteria.

Verwenden

Quinupristin is a semi-synthetic analogue of virginiamycin B (ostreogyrcin B, pristinamycin IA, streptogramin B) formed by a Mannich condensation and elimination to generate an exocyclic methylene alpha to the ketone of the 4-piperidinone. Addition of quinucidinylthiol to the methylene group affords quinupristin. The structural changes provide a more hydrophobic compound with a readily ionisable group for generating a salt. Quinupristin is used commercially in synergistic combination with dalfopristin (30:70). There is little published data on the synthesis, biological or antibiotic activity of quinupristin alone, however the combination product is highly effective, including activity against antibiotic resistant strains.

Quinupristin Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Quinupristin Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 69)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Shaanxi Xianhe Biotech Co., Ltd
+86-17709210191; +8617709210191
Jerry@xhobio.com China 906 58
TargetMol Chemicals Inc.
+1-781-999-5354; +17819995354
marketing@targetmol.com United States 32466 58
Shenzhen Shengda Pharma Limited
755-85269922 +8613424394241
sales@shengdapharm.com CHINA 310 58
BOC Sciences
16314854226; +16314854226
inquiry@bocsci.com United States 19853 58
Dayang Chem (Hangzhou) Co.,Ltd.
+86-0571-88938639 +8617705817739
info@dycnchem.com China 52704 58
TargetMol Chemicals Inc.
+1-781-999-5354;
support@targetmol.com United States 39039 58
PT CHEM GROUP LIMITED
+86-85511178;
peter68@ptchemgroup.com China 35425 58
GIHI CHEMICALS CO.,LIMITED
+86-571-86217390; +8618058761490
info@gihichemicals.com China 49952 58
Wuhan Topule Biopharmaceutical Co., Ltd
+8618327326525
masar@topule.com China 8467 58
Aladdin Scientific

tp@aladdinsci.com United States 57505 58

120138-50-3()Verwandte Suche:


  • 4-[4-(DiMethylaMino)-N-Methyl-L-phenylalanine]-5-[(2S,5R)-5-[[[(3S)-1-azabicyclo[2.2.2]oct-3-yl]thio]Methyl]-4-oxo-2-piperidinecarboxylic acid]virginiaMycin S1
  • Antibiotic RP 57669
  • RP 57669
  • RP 68888
  • Quinupristin(RP-57669)
  • Quinupristin Discontinued
  • Quinupristin Mesylate
  • Virginiamycin S1, 4-[4-(dimethylamino)-N-methyl-L-phenylalanine]-5-[(2S,5R)-5-[[[(3S)-1-azabicyclo[2.2.2]oct-3-yl]thio]methyl]-4-oxo-2-piperidinecarboxylic acid]-
  • Quinupristin/dalfopristin,Quinupristin,antibiotic,Quinupristin-dalfopristin,streptogramin,Inhibitor,Bacterial,inhibit
  • 120138-50-3
  • C53H67N9O10S
  • Amino Acids & Derivatives
  • Aromatics
  • Chiral Reagents
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
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