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Flunoxaprofen

Flunoxaprofen Struktur
66934-18-7
CAS-Nr.
66934-18-7
Englisch Name:
Flunoxaprofen
Synonyma:
Priaxim;Flunoxaprofen;S-(+)-Flunoxaprofen;Flunoxaprofen USP/EP/BP;(S)-2-(4-Fluorophenyl)-α-methyl-5-benzoxazoleacetic acid;5-Benzoxazoleacetic acid, 2-(4-fluorophenyl)-α-methyl-, (αS)-
CBNumber:
CB81178784
Summenformel:
C16H12FNO3
Molgewicht:
285.273
MOL-Datei:
66934-18-7.mol

Flunoxaprofen Eigenschaften

Schmelzpunkt:
162-164°
alpha 
D20 +50° (c = 2% in DMF)
Siedepunkt:
419.4±30.0 °C(Predicted)
Dichte
1.334±0.06 g/cm3(Predicted)
pka
4.36±0.30(Predicted)

Sicherheit

Toxizit?t LD50 orally in mice: ~1200 mg/kg (Dunwell)

Flunoxaprofen Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Flunoxaprofen is an antiinflammatory related to now withdrawn benoxaprofen, reportedly useful in the treatment of rheumatoid arthritis, myositis, synovitis and osteoarthritis. Its major mechanism of action is reported to be lipoxygenase inhibition, thus enabling the control of inflammation with less severe gastric disturbances.

Definition

ChEBI: A monocarboxylic acid that is propionic acid substituted at position 2 by a 2-(4-chlorophenyl)-1,3-benzoxazol-5-yl group (the S-enantiomer). Although it was shown to be effective in treatment of rheumatoid arthritis and osteoarthritis, the clinical use of flunoxaprofen was discontinued due to possible hepatotoxic side-effects.

Flunoxaprofen Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Flunoxaprofen Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

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  • Flunoxaprofen
  • (S)-2-(4-Fluorophenyl)-α-methyl-5-benzoxazoleacetic acid
  • Priaxim
  • S-(+)-Flunoxaprofen
  • Flunoxaprofen USP/EP/BP
  • 5-Benzoxazoleacetic acid, 2-(4-fluorophenyl)-α-methyl-, (αS)-
  • 66934-18-7
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