(5S,6Z,8E,10E,14Z)-5-hydroxy-12-oxoicosa-6,8,10,14-tetraenoic acid Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Leukotriene B₄ (LTB₄) is a dihydroxy fatty acid derived from arachidonic acid through the 5-LO pathway. It promotes a number of leukocyte functions including aggregation, stimulation of ion fluxes, enhancement of lysosomal enzyme release, superoxide anion production, chemotaxis, and chemokinesis. 12-oxo LTB₄ is an initial metabolite of LTB₄ formed via the LTB₄ 12-hydroxydehydrogenase pathway. It is rapidly converted to 10,11-dihydro-12-oxo-LTB₄, followed by reduction of the 12-oxo group to give 10,11-dihydro-LTB₄. 12-oxo-LTB₄ (EC₅₀ = 33 nM) is about 70-fold less potent than LTB₄ (EC₅₀ = 0.46 nM) at stimulating Ca²⁺ mobilization in human neutrophils. It is also significantly less potent than LTB₄ at stimulating neutrophil migration with EC₅₀ values of 170 and 2.7 nM for 12-oxo-LTB₄ and LTB₄, respectively.

Definition

ChEBI: A long-chain fatty acid consisting of leukotriene B4 having a 12-keto group in place of the 12-hydroxy group.

(5S,6Z,8E,10E,14Z)-5-hydroxy-12-oxoicosa-6,8,10,14-tetraenoic acid Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

(5S,6Z,8E,10E,14Z)-5-hydroxy-12-oxoicosa-6,8,10,14-tetraenoic acid Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
TargetMol Chemicals Inc.	+1-781-999-5354; +17819995354	marketing@targetmol.com	United States	32466	58
Shanghai Hongye Biotechnology Co. Ltd	400-9205774	sales@glpbio.cn	China	6777	58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	18818260767	sales@chemegen.com	China	11218	58
Energy Chemical	021-58432009 400-005-6266	marketing@energy-chemical.com	China	44918	58
Shanghai Yiyan Biotechnology Co. , Ltd.	021-69985186 13611928337	3427709316@qq.com	China	7982	58
Shanghai Yifei Biotechnology Co. , Ltd.	021-65675885 18964387627	customer_service@efebio.com	China	11972	58
TargetMol Chemicals Inc.	15002134094	marketing@targetmol.cn	China	29867	58
Cayman Chemical Company	--	sales@caymanchem.com	China	6838	58
Santa Cruz Biotechnology Inc	--	scbt@scbt.com	China	6594	58
Guangzhou Qingyan Biotechnology Co., Ltd.	--		CHINA	6470	58

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• (5S,6Z,8E,10E,14Z)-5-hydroxy-12-oxoicosa-6,8,10,14-tetraenoic acid
• 12-Keto-leukotriene B4
• 12-oxoleukotriene B4
• 12-Oxo-ltb4
• 6,8,10,14-Eicosatetraenoic acid, 5-hydroxy-12-oxo-, (S-(E,Z,E,Z))-
• 12-dehydro-leukotriene B4
• SJVWVCVZWMJXOK-NOJHDUNKSA-N
• 6,8,10,14-Eicosatetraenoic acid, 5-hydroxy-12-oxo-, (5S,6Z,8E,10E,14Z)-
• 12-oxo Leukotriene B4 in acetonitrile, CAS 136696-10-1
• 136696-10-1