Abiraterone acetate
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- CAS-Nr.
- 154229-18-2
- Englisch Name:
- Abiraterone acetate
- Synonyma:
- ZYTIGA;(3S,8R,9S,10R,13S,14S)-10,13-dimethyl-17-(pyridin-3-yl)-2,3,4,7,8,9,10,11,12,13,14,15-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl acetate;17-(3-pyridyl)-5,16-androstadien-3beta-acetate;ABITATERONE ACETATE;Abiraterone Acotate;(3β)-17-(3-pyridinyl) androsta-5,16-dien-3-yl acetate;(3)-17-(3-Pyridinyl)androsta-5,16-dien-3-ol Acetate (Ester);(3beta)-17-(3-pyridinyl)-Androsta-5,16-dien-3-ol acetate (ester);[(3S,8R,9S,10R,13S,14S)-10,13-dimethyl-17-pyridin-3-yl-2,3,4,7,8,9,11,12,14,15-decahydro-1H-cyclopenta[a]phenanthren-3-yl] acetate;CS-212
- CBNumber:
- CB81396153
- Summenformel:
- C26H33NO2
- Molgewicht:
- 391.55
- MOL-Datei:
- 154229-18-2.mol
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Abiraterone acetate Eigenschaften
- Schmelzpunkt:
- 127-130°C
- Siedepunkt:
- 506.7±50.0 °C(Predicted)
- Dichte
- 1.14±0.1 g/cm3(Predicted)
- storage temp.
- -20°C
- L?slichkeit
- Chloroform (Slightly), DMSO (Sparingly), Methanol (Sparingly)
- pka
- 5.31±0.12(Predicted)
- Aggregatzustand
- powder
- Farbe
- white to beige
- InChIKey
- UVIQSJCZCSLXRZ-UBUQANBQSA-N
- SMILES
- C1[C@@]2(C)C(=CC[C@]3([H])[C@]2([H])CC[C@]2(C)C(C4=CC=CN=C4)=CC[C@@]32[H])C[C@@H](OC(=O)C)C1
Abiraterone acetate Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
In April 2011, the United States FDA approved abiraterone acetate
(CB7630) in combination with the steroid prednisone for the treatment
of metastatic castration-resistant prostate cancer (mCRPC) for patients
who were previously treated with a docetaxel containing regimen for
late-stage disease. Abiraterone acetate affects prostate, testicular, and adrenal androgens by irreversibly inhibiting
both the lyase and hydroxylase activity of cytochrome P450 17A
(CYP17) signaling pathways (IC
50's of 2.9 and 4 nM, respectively) thereby
decreasing testosterone levels.Most common serious adverse events for abiraterone acetate versus placebo included fluid retention (30.5% vs. 22.3%), hypokalemia (17.1% vs. 8.4%), hypertension (9.7% vs. 7.9%), hepatic transaminase abnormalities (10.4% vs. 8.1%), and cardiac abnormalities (13.3% vs. 10.4%).
Chemische Eigenschaften
Off-White Solid
Verwenden
Abiraterone acetate is a novel steroidal inhibitor of human Cytochrome P450 (17α-Hydroxylase-C17,20-lyase): potential agent for the treatment of prostatic cancer.
Definition
ChEBI: A sterol ester obtained by formal condensation of the 3-hydroxy group of abiraterone with the carboxy group of acetic acid. A prodrug that is converted in vivo to abiraterone. Used for treatment of metastatic castrate-resistant prostate cance
.
Abiraterone acetate Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Abiraterone acetate Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 654)Lieferanten
| Firmenname |
Telefon |
E-Mail |
Land |
Produktkatalog |
Edge Rate |
|
Joyochem Co.,Ltd
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+86-0531-82687998 +8615153169511
|
sales01@joyochem.com |
China |
30 |
58 |
|
Improve Medical Technology(Nanxiong) Co.,Ltd
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+86-13711621707
|
Jimin211@foxmail.com |
China |
21 |
58 |
|
Hebei Chuanghai Biotechnology Co., Ltd
|
+86-15350571055
|
Sibel@chuanghaibio.com |
China |
8738 |
58 |
|
Hebei Yanxi Chemical Co., Ltd.
|
+86-17531190177
|
faithe@yan-xi.com |
China |
5853 |
58 |
|
Hangzhou ICH Biofarm Co., Ltd
|
+86-0571-28186870; +undefined8613073685410
|
sales@ichemie.com |
China |
1006 |
58 |
|
Shaanxi Haibo Biotechnology Co., Ltd
|
+86-18629295024
|
qinhe02@xaltbio.com |
China |
997 |
58 |
|
Anhui Ruihan Technology Co., Ltd
|
+undefined17756083858
|
daisy@anhuiruihan.com |
China |
973 |
58 |
|
Nantong Guangyuan Chemicl Co,Ltd
|
+86-17331189928
|
admin@guyunchem.com |
China |
615 |
58 |
|
Wuhan JiyunZen Tech Co., Ltd.
|
+86-18062099985
|
Amyjiyunzen@yeah.net |
China |
672 |
58 |
|
Capot Chemical Co.,Ltd.
|
+86-（0）57185586718 +86-13336195806
|
sales@capot.com |
China |
29640 |
60 |
154229-18-2()Verwandte Suche:
Etofibrat
Prasteron
3β-Hydroxyandrost-5-en-17-onacetat
20-Hydroxyiminopregna-5,16-dien-3-β-ylacetat
20-Oxopregna-5,16-dien-3-β-ylacetat
2-Methoxy-4-(2-propenyl)phenol-acetat
Phenethylacetat
Phenylacetat
[3R-(3α,3aβ,6α,7β,8aα)]-Octahydro-3,6,8,8-tetramethyl-1H-3a,7-methanoazulen-5-ylacetat
Pentylacetat
n-Butylacetat
Cinnamylacetat
5-Butyl-2-ethylamino-6-methylpyrimidin-4-yldimethylsulfamat
exo-1,7,7-Trimethylbicyclo[2.2.1]hept-2-ylacetat
Bromethylmagnesium
tert-Butylacetat
Hydantoin
Trichlorethylsilan
- Abiraterone acetate 99.5%
- Abiraterone acetate(CB7630)
- 3β-acetoxy-17-(3-pyridyl)androsta-5,16-diene
- 2-((3S,8R,9S,10R,13S,14S)-10,13-diMethyl-17-(pyridin-3-yl)-2,3,4,7,8,9,10,11,12,13,14,15-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl)acetate
- Abiraterone acetate ester
- Androsta-5,16-dien-3-ol,17-(3-pyridinyl)-, acetate (ester), (3b)-
- Abiraterone Acetate impurity
- Abiraterone acetate, >=99%
- Abirteroneacetate
- 2-((3S,8R,9S,10R,13S,14S)-10,13-Dimethyl-17-(pyridin-3-yl)-2,3,4,7,8,9,10,11,12,13,14,15-dodec
- Abiraterone Acetate
- CB 7630
- Abiraterone acetate - CB 7630 | JNJ 212082
- CS-212
- Androsta-5,16-dien-3-ol,17-(3-pyridinyl)
- 3-Epi-abiraterone Acetate stereoisomer
- Abiraterone Acetate >
- 17-(3-pyridyl)-5,16-androstadien-3beta-acetatee
- 17-(Pyridin-3-yl)androsta-5,16-dien-3β-yl acetate
- Androsta-5,16-dien-3-ol, 17-(3-pyridinyl)-, acetate (ester), (3β)-
- Abiraterone Impurity 81
- 3beta-17-(3-Pyridyl)androsta-5,16-dien-3-ol Acetate
- Abiraterone acetate ISO 9001：2015 REACH
- (3aS,3bR,7S,9aR,9bS,11aS)-9a,11a-dimethyl-1-(pyridin-3-yl)-3H,3aH,3bH,4H,6H,7H,8H,9H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-7-yl acetate
- Abiraterone acetate (USFDA)
- Abiraterone acetate- USP
- Abiraterone Acetate CAS 154229-18-2
- (3β)-17-(3-pyridyl)- androsta-5,16-dien-3-ol-acetate
- Abiraterone Acetate (Zytiga
- formerly CB-7598
- Abiraterone Acetate D4Q: What is
Abiraterone Acetate D4 Q: What is the CAS Number of
Abiraterone Acetate D4 Q: What is the storage condition of
Abiraterone Acetate D4 Q: What are the applications of
Abiraterone Acetate D4
- Abiraterone Acetate (1000818)
- 8-Dihydroxyquinaldic acid
- (3beta)-17-(3-pyridinyl)-Androsta-5,16-dien-3-ol acetate (ester)
- 17-(3-pyridyl)-5,16-androstadien-3beta-acetate
- (3)-17-(3-Pyridinyl)androsta-5,16-dien-3-ol Acetate (Ester)
- ZYTIGA
- Abiraterone Acotate
- [(3S,8R,9S,10R,13S,14S)-10,13-dimethyl-17-pyridin-3-yl-2,3,4,7,8,9,11,12,14,15-decahydro-1H-cyclopenta[a]phenanthren-3-yl] acetate
- Abiteron Acetate
- Abiraterone WS
- (3S,8R,9S,10R,13S,14S)-10,13-Dimethyl-17-(3-pyridyl)-2,3,4,7,8,9,10,11,12,13,14,15-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl Acetate
- ABIRATERONE ACTATE
- Abiraterone Acetate, 10 mM in DMSO
- Abiretorone
- Abiraterone acetate - Bio-X ?
- (3β)-17-(3-pyridinyl) androsta-5,16-dien-3-yl acetate
- (3S,8R,9S,10R,13S,14S)-10,13-dimethyl-17-(pyridin-3-yl)-2,3,4,7,8,9,10,11,12,13,14,15-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl acetate
- ABITATERONE ACETATE
- 154229-18-2
- 54229-18-2
- C26H32NO2
- Inhibitors
- Inhibitor
- Final material
- Anti-cancer & immunity
- DQM
- API
