Lineomycin Hydrochloride
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- CAS-Nr.
- 859-18-7
- Bezeichnung:
- Lineomycin Hydrochloride
- Englisch Name:
- Lincomycin hydrochloride
- Synonyma:
- LINCOMYCIN HCL;Lincomycin hydrochloride monohydrate;Lincomycin HCI;Lincorex;Lintamycin;METHYL 6,8-DIDEOXY-6-(1-METHYL-4-PROPYL-2-PYRROLIDINECARBOXAMIDO)-1-THIO-D-ERYTHRO-ALPHA-D-GALACTOOCTOPYRANOSIDE HYDROCHLORIDE;(2S,4R)-N-((1R,2R)-2-Hydroxy-1-((2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(methylthio)tetrahydro-2H-pyran-2-yl)propyl)-1-methyl-4-propylpyrrolidine-2-carboxamide hydrochloride;Lizpion;U-10149A;Lincogap
- CBNumber:
- CB8141837
- Summenformel:
- C18H35ClN2O6S
- Molgewicht:
- 443
- MOL-Datei:
- 859-18-7.mol
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Lineomycin Hydrochloride Eigenschaften
- Schmelzpunkt:
- 156-158C
- storage temp.
- 2-8°C
- L?slichkeit
- H2O: 50 mg/mL, clear, colorless
- Aggregatzustand
- solid
- Farbe
- white to white with yellow cast
- Wasserl?slichkeit
- Soluble in water.
- BRN
- 4171650
- Stabilit?t:
- Hygroscopic
- InChIKey
- POUMFISTNHIPTI-BOMBIWCESA-N
- SMILES
- [C@]([H])([C@]1([H])[C@@H]([C@H](O)[C@@H](O)[C@@H](SC)O1)O)([C@H](O)C)NC([C@H]1N(C[C@H](CCC)C1)C)=O.Cl |&1:0,2,4,5,7,9,14,19,22,r|
- EPA chemische Informationen
- D-erythro-.alpha.-D-galacto-Octopyranoside, methyl 6,8-dideoxy-6-[[[(2S,4R)-1-methyl-4-propyl-2-pyrrolidinyl]carbonyl]amino]-1-thio-, hydrochloride (1:1) (859-18-7)
Lineomycin Hydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R20/21/22:Gesundheitssch?dlich beim Einatmen,Verschlucken und Berührung mit der Haut.
S-S?tze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Chemische Eigenschaften
Crystalline
Verwenden
Lincomycin hydrochloride is a salt of lincomycin formed at the basic N-methylproline. The hydrochloride salt is the preferred formulation for pharmaceutical use. Lincomycin hydrochloride is a broad spectrum antibiotic with activity against anaerobic bacteria and protozoans. Lincomycin acts by binding to the 23S ribosomal subunit, blocking protein synthesis. Lincomycin has been extensively studied with over 7,000 literature citations.
Allgemeine Beschreibung
Chemical structure: macrolide
Clinical Use
Lincomycin is used for the treatment of infections causedby Gram-positive organisms, notably staphylococci, β-hemolyticstreptococci, and pneumococci. It is absorbed moderatelywell orally and distributed widely in the tissues.Effective concentrations are achieved in bone for the treatmentof staphylococcal osteomyelitis but not in the cerebrospinalfluid for the treatment of meningitis. At one time,lincomycin was considered a nontoxic compound, with alow incidence of allergy (rash) and occasional GI complaints(nausea, vomiting, and diarrhea) as the only adverseeffects. Recent reports of severe diarrhea and the developmentof pseudomembranous colitis in patients treated withlincomycin (or clindamycin), however, have necessitatedreappraisal of the role of these antibiotics in therapy. In anyevent, clindamycin is superior to lincomycin for thetreatment of most infections for which these antibiotics areindicated.
Lincomycin hydrochloride occurs as the monohydrate, awhite, crystalline solid that is stable in the dry state. It isreadily soluble in water and alcohol, and its aqueous solutionsare stable at room temperature. It is degraded slowlyin acid solutions but is absorbed well from the GI tract.Lincomycin diffuses well into peritoneal and pleural fluidsand into bone. It is excreted in the urine and the bile. It isavailable in capsule form for oral administration and inampules and vials for parenteral administration.
Lineomycin Hydrochloride Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Lineomycin Hydrochloride Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 634)Lieferanten
859-18-7(Lineomycin Hydrochloride)Verwandte Suche:
- LINCOMYCIN HYDROCHLORIDE
- LINCOCIN HYDROCHLORIDE
- lincomycin standard solution
- ALPHA-METHYL-6,8-DIDEOXY-6-[1-METHYL-4-PROPYL-2-PYRROLIDINECARBOXAMIDO]-1-THIO-D-ERYTHRO-D-GALACTOOCTOPYRANOSIDE HYDROCHLORIDE
- U-10149A
- N-[2-HYDROXY-1-(3,4,5-TRIHYDROXY-6-METHYLSULFANYL-OXAN-2-YL)-PROPYL]-1-METHYL-4-PROPYL-PYRROLIDINE-2-CARBOXAMIDE
- D-erythro-.alpha.-D-galacto-Octopyranoside, methyl 6,8-dideoxy-6-(2S,4R)-1-methyl-4-propyl-2-pyrrolidinylcarbonylamino-1-thio-, monohydrochloride
- lincomycin solution
- D-erythro-a-D-galacto-Octopyranoside, methyl 6,8-dideoxy-6-[[(1-methyl-4-propyl-2-pyrrolidinyl)carbonyl]amino]-1-thio-, monohydrochloride, (2S-trans)-
- D-erythro-a-D-galacto-Octopyranoside, methyl 6,8-dideoxy-6-[[[(2S,4R)-1-methyl-4-propyl-2-pyrrolidinyl]carbonyl]amino]-1-thio-, monohydrochloride (9CI)
- D-erythro-D-galacto-Octopyranoside, methyl 6,8-dideoxy-6-(1-methyl-4-propyl-L-2-pyrrolidinecarboxamido)-1-thio-, monohydrochloride, trans-a- (8CI)
- Lincogap
- LINCOMYCINHYDROCHLORIDEANHYDROUS
- LINCOMYCIN CHLOROHYDRATE
- Lincocin
- Lincomycin hydrochloride BP98
- Methyl (2S-trans)-6,8-dideoxy-6-[[(1-methyl-4-propylpyrrolidin-2-yl)carbonyl]amino]-1-thio-D-erythro-alpha-D-galacto-octopyranoside monohydrochloride
- LINCOMYCIN HYDROCHLORIDE CELL CULTURE*TE STED
- Linocin, NSC 70731, U 10149a
- methyl 6,8-dideoxy-6-[[[(2S,4R)-1-methyl-4-propyl-2-pyrrolidinyl]carbonyl]amino]-1-thio-D-erythro-α-D-galacto-octopyranoside,hydrochloride (1:1)
- Lincoymcin Hcl
- Lincomycin hydrochloride (Lincocin)
- Lineomycin Hydrochloride
- Lincomycin (U-10149A)
- Lizpion
- Luniamycin
- Pelancocin
- Lincocin hydrochloride, Methyl 6,8-dideoxy-6-(1-methyl-4-propyl-2-pyrrolidinecarboxamido)-1-thio-D-erythro-α-D-galactooctopyranoside hydrochloride
- Methyl 6,8-dideoxy-6-trans-(1-methyl-4-propyl-L-2-pyrrolidinecarboxamido)-1-thio-D-erythro-alpha-D-galacto-octopyranoside hydrochloride
- Methyl 6,8-dideoxy-6-(1-methyl-4-propyl-2-pyrrolidinecarboxamido)-1-thio-D-erythro-α-D-galactooctopyranoside hydrochloride
- (2S,4R)-N-{(1S)-2-hydroxy-1-[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(methylthio)-tetrahydro-2H-2-pyranyl]propyl}-1-methyl-4-propylpyrrolidine-2-carboxamide Hydrochloride
- (2S-trans)-Methyl 6,8-Dideoxy-6-[[(1-Methyl-4-propyl-2-pyrrolidinyl)carbonyl]
aMino]-1-thio-D3-threo-α-D-galactooctopyranoside Hydrochloride
- LincoMycin hydrochloride (U-10149A)
- Lincomycin hydrochloride,Lincocin hydrochloride, Methyl 6,8-dideoxy-6-(1-methyl-4-propyl-2-pyrrolidinecarboxamido)-1-thio-D-erythro-α-D-galactooctopyranoside hydrochloride
- Lincomycin hydrochloride 90%
- LINCOMYCIN HYDROCHLORIDE >= 95.0% (T
- LINOCOMYCIN HYDROCHLORIDE
- (2S,E)-Methyl-6,8-didezoxy-6(1-methyl-4-propylpirrolidine-yl-carbonylamino)-1-thio-D-eritro-a-D-halaktooktopiranoziide, hydrochloride monohydrate
- Lyncomycin,HCl
- Lincocin hydrocheoride
- Lincomycin Hydrochloride CAS 859-18-7
- D-erythro-a-D-galacto-Octopyranoside, methyl6,8-dideoxy-6-[[[(2S,4R)-1-methyl-4-propyl-2-pyrrolidinyl]carbonyl]amino]-1-thio-,hydrochloride
- Lincomycin hydrochloride Solution, 100ppm
- Lincomycin hydrochloride Solution, 1000ppm
- incomycin hydrochL
- Lincomycin hydrochloride Solution in Methanol, 100μg/mL
- Lincomycin hydrochloride USP/EP/BP
- Lincocin Hcl
- (2S-trans)-Methyl 6,8-Dideoxy-6-[[(1-methyl-4-propyl-2-pyrrolidinyl)carbonyl]
- Lincomycin HydrochlorideQ: What is
Lincomycin Hydrochloride Q: What is the CAS Number of
Lincomycin Hydrochloride Q: What is the storage condition of
Lincomycin Hydrochloride Q: What are the applications of
Lincomycin Hydrochloride
- Lincomycin Hydrochloride Bp/Ep
- METHYL 6,8-DIDEOXY-6-(1-METHYL-4-PROPYL-2-PYRROLIDINECARBOXAMIDO)-1-THIO-D-ERYTHRO-ALPHA-D-GALACTOOCTOPYRANOSIDE HYDROCHLORIDE
- Lincorex
- Lintamycin
- D-erythro-a-D-galacto-Octopyranoside, methyl6,8-dideoxy-6-[[[(2S,4R)-1-methyl-4-propyl-2-pyrrolidinyl]carbonyl]amino]-1-thio-,hydrochloride (1:1)
- Lincomycin hydrochloride (7CI)
- Clindamycin EP Impurity A HCl
- (2S,4R)-N-[(1R,2R)-2-Hydroxy-1-[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(methylthio)-tetrahydro-2H-2-pyranyl]propyl]-1-methyl-4-propylpyrrolidine-2-carboxamide Hydrochloride
