PRIMA-1
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- CAS-Nr.
- 5608-24-2
- Englisch Name:
- PRIMA-1
- Synonyma:
- PRIMA-1;NSC-281668;PRIMA-1, 10 mM in DMSO;2,2-dimethylolquinuclidin-3-one;PRIMA-1 - CAS 5608-24-2 - Calbiochem;2-Bis(hydroxymethyl)-3-quinuclidinone;2,2-Bis(hydroxymethyl)quinuclidin-3-one;2,2-BIS(HYDROXYMETHYL)-3-QUINUCLIDINONE;P53 REACTIVATION AND INDUCTION OF MASSIVE APOPTOSIS;7,7-bis(hydroxymethyl)-1-azabicyclo[2.2.2]octan-8-one
- CBNumber:
- CB8165699
- Summenformel:
- C9H15NO3
- Molgewicht:
- 185.22
- MOL-Datei:
- 5608-24-2.mol
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PRIMA-1 Eigenschaften
- Schmelzpunkt:
- 146-147 °C
- Siedepunkt:
- 353.7±17.0 °C(Predicted)
- Dichte
- 1.32±0.1 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,2-8°C
- L?slichkeit
- H2O: >10mg/mL
- pka
- 13.68±0.10(Predicted)
- Aggregatzustand
- solid
- Farbe
- white to off-white
- Wasserl?slichkeit
- Soluble in water at 10mg/ml
- Sensitive
- Light Sensitive
- InChI
- 1S/C9H15NO3/c11-5-9(6-12)8(13)7-1-3-10(9)4-2-7/h7,11-12H,1-6H2
- InChIKey
- RFBVBRVVOPAAFS-UHFFFAOYSA-N
- SMILES
- OCC1(CO)N2CC[C@@H](CC2)C1=O
PRIMA-1 Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
PRIMA-1 is a reactivator of p53 and inducer of apoptosis.
Biologische Aktivit?t
Selectively restores mutant p53 activity in tumor cells via activation of Bax and PUMA. Induces apoptosis and inhibits growth of human tumors with mutant p53.
PRIMA-1 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
PRIMA-1 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 150)Lieferanten
5608-24-2()Verwandte Suche:
- PRIMA-1
- P53 REACTIVATION AND INDUCTION OF MASSIVE APOPTOSIS
- 2,2-BIS(HYDROXYMETHYL)-1-AZABICYCLO[2,2,2]OCTAN-3-ONE
- 2,2-BIS(HYDROXYMETHYL)-3-QUINUCLIDINONE
- 2,2-dimethylolquinuclidin-3-one
- 7,7-bis(hydroxymethyl)-1-azabicyclo[2.2.2]octan-8-one
- PRIMA-1 - CAS 5608-24-2 - Calbiochem
- 2-Bis(hydroxymethyl)-3-quinuclidinone
- NSC-281668
- 1-Azabicyclo[2.2.2]octan-3-one, 2,2-bis(hydroxymethyl)-
- 2,2-Bis(hydroxymethyl)quinuclidin-3-one
- PRIMA-1, 10 mM in DMSO
- 5608-24-2
- Caspases/Apoptosis
